Review
Engineering, Environmental
Ashiq Ahamed, Lili Liang, Ming Yang Lee, Johan Bobacka, Grzegorz Lisak
Summary: Engineered nanomaterials (ENMs) are a novel class of materials with superior physicochemical properties compared to conventional materials, but can potentially release into the environment and pose toxic effects. Research focuses on the transformations and potential risks of ENMs in consumer products, aiming to ensure their safe application.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Food Science & Technology
Maria Alonso-Jauregui, Maria Font, Elena Gonzalez-Penas, Adela Lopez de Cerain, Ariane Vettorazzi
Summary: Humans are widely exposed to a great variety of mycotoxins and their mixtures, so it is important to prioritize mycotoxins based on their toxic potential. A strategy combining in silico tools and in vitro tests was used to classify 12 mycotoxins and evaluate their mutagenic potential, showing different mutagenic potentials and the role of metabolic activation in some mycotoxins.
Article
Chemistry, Multidisciplinary
Sarah May, Cordula Hirsch, Alexandra Rippl, Alexander Buerkle, Peter Wick
Summary: This study investigated the genotoxicity of different engineered nanomaterials (ENMs) using two complementary in vitro assays. The results showed that certain ENMs exhibited cytotoxicity and genotoxicity, while others did not have these effects.
Article
Chemistry, Multidisciplinary
Danielle Mulder, Cornelius Johannes Francois Taute, Mari van Wyk, Pieter J. Pretorius
Summary: The study found that functionalized GNPs caused genotoxicity in HepG2 cells, but the cells were able to initiate repair mechanisms and recover DNA damage, except for two functionalization chemistries.
Article
Chemistry, Multidisciplinary
Vanessa Valdiglesias, Natalia Fernandez-Bertolez, Carlota Lema-Arranz, Raquel Rodriguez-Fernandez, Eduardo Pasaro, Ana Teresa Reis, Joao Paulo Teixeira, Carla Costa, Blanca Laffon
Summary: The study confirmed the suitability of salivary leucocytes as a biological sample for in vitro nanogenotoxicity studies, and demonstrated an increase in DNA damage caused by metal oxide NPs. These findings contribute to a better understanding of the impact of NPs on human health, highlighting the need for specific regulation in the use of nanomaterials.
Article
Environmental Sciences
Sergey Petrovich Kukla, Valentina Vladimirovna Slobodskova, Elena Vladimirovna Zhuravel, Andrey Alexandrovich Mazur, Viktor Pavlovich Chelomin
Summary: The increase in the number of products containing nanoparticles (NPs) poses a real threat to the environment. Although the acute toxicity of most aquatic NPs has been well documented, there is relatively little research on the long-term effects of NPs on the reproductive system and gamete quality of aquatic organisms. In an experiment on the sand dollar, exposure to copper oxide nanoparticles (CuO NPs) resulted in copper accumulation in tissues, increased lipid peroxidation product concentrations, decreased fertilization rate, and increased sperm DNA damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Biomedical
Ranran Guo, Siqi Wang, Lin Zhao, Qida Zong, Tiancheng Li, Guixia Ling, Peng Zhang
Summary: Nanomaterial-synergized photodynamic therapy and photothermal therapy have significant advantages in fighting cancer. Researchers are now focusing on combining these therapies with immunotherapy by using nanomaterials to promote the maturation of immune cells and infiltration of immune cells, aiming to improve the treatment effectiveness.
Article
Chemistry, Multidisciplinary
Adriana Rodriguez-Garraus, Maria Alonso-Jauregui, Ana-Gloria Gil, Inigo Navarro-Blasco, Adela Lopez de Cerain, Amaya Azqueta
Summary: A new material composed of kaolin base with silver nanoparticles was developed as an alternative to antibiotics in animal feed. In an in vivo geno-toxicological evaluation in rats, the material showed no adverse effects when administered orally at a dose of 2000 mg/kg b.w. for 28 days. The material did not induce micronuclei or DNA damage in various tissues, and silver content in target organs confirmed the negative results.
Article
Toxicology
Mai Salama, Doaa A. El Morsi, Osama Shabka, Nermin M. Emam
Summary: The study assessed the genotoxicity of silver nanoparticles on lymphocyte cells using comet assay, finding that different doses of AgNPs caused irreversible DNA damage, with a degree of reversibility after exposure cessation.
TOXICOLOGY RESEARCH
(2021)
Review
Public, Environmental & Occupational Health
Eleonora Scarcello, Adriana Sofranko, Tina Wahle, Roel P. F. Schins
Summary: Testing of engineered nanomaterials in neurotoxicology faces challenges due to their complex physicochemical properties and lack of toxicokinetic data, which may induce indirect neurotoxic effects.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Chemistry, Physical
Sara Cardoso, Classius F. da Silva, Patricia Severino, Amelia M. Silva, Selma B. Souto, Aleksandra Zielinska, Jacek Karczewski, Eliana B. Souto
Summary: Nanocomposites, such as metal nanoparticles, are widely used in biomedical applications, including drug delivery systems. Green nanocomposites made of biocompatible and biodegradable nanoparticles are considered safer options. However, concerns about the potential health risks, including DNA damage, due to the enhanced reactivity of metal nanoparticles have led to the development of the Comet Assay for genotoxicity assessment. This assay plays a crucial role in evaluating the safety and efficacy of metal nanoparticles in drug delivery systems.
Article
Biophysics
Joana B. Ferrado, Adrian A. Perez, Malen Menegon, Victoria A. Vaillard, Fatima Gasser, Maria E. Baravalle, Hugo H. Ortega, Santiago E. Vaillard, Liliana G. Santiago
Summary: In this study, self-assembled bovine serum albumin nanoparticles loaded with genistein were PEGylated to avoid possible immunogenic reactions and rapid clearance from the bloodstream. The PEGylation process increased the particle size of the nanoparticles and improved their biological properties, reducing cytotoxicity and genotoxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Maria Joao Bessa, Fatima Brandao, Paul H. B. Fokkens, Daan L. A. C. Leseman, A. John F. Boere, Flemming R. Cassee, Apostolos Salmatonidis, Mar Viana, Adriana Vulpoi, Simion Simon, Eliseo Monfort, Joao Paulo Teixeira, Sonia Fraga
Summary: Diverse industries have incorporated engineered nanoparticles (ENP) into their production processes, increasing the risk of worker inhalation exposure. In vitro models, particularly using air-liquid interface (ALI) cell cultures, are valuable for studying ENP toxicity. When comparing submerged and ALI conditions for ENP exposure, it was found that ALI cultures were more sensitive to the cytotoxic effects of ENP on human alveolar epithelial-like cells.
Article
Chemistry, Analytical
Jin-Bao Tang, Hong-Ming Yang, Xiao-Yi Gao, Xian-Zhong Zeng, Feng-Shan Wang
Summary: A novel antibody conjugation strategy was developed to immobilize antibodies in a directional and covalent manner, significantly improving the sensitivity of solid-phase immunoassay. This approach can be used for surface functionalization to detect various biomarkers with increased sensitivity.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Physical
S. Garcia-Carpintero, V. Jehova Gonzalez, J. Frontinan-Rubio, A. Esteban-Arranz, E. Vazquez, M. Duran-Prado
Summary: In recent years, the genotoxicity of graphene-related materials (GRMs) and other 2D materials has been evaluated using different models. The OECD TG 487 in vitro micronucleus (MNu) test is commonly used to assess the genotoxicity of nanomaterials (NMs). However, the nature of NMs interferes with the standard MNu process, requiring adaptations. The study proposes a modified in vitro MNu test with improvements to accurately test the genotoxicity of NMs, demonstrating risks associated with graphene oxide (GO) and boron nitride (hBN).
Article
Marine & Freshwater Biology
Sara Norgaard Sorensen, Henning Wigger, Alex Zabeo, Elena Semenzin, Danail Hristozov, Bernd Nowack, David J. Spurgeon, Anders Baun
AQUATIC TOXICOLOGY
(2020)
Article
Toxicology
Emilie Da Silva, Anders Baun, Elisabet Berggren, Andrew Worth
TOXICOLOGY LETTERS
(2020)
Article
Multidisciplinary Sciences
Lars Michael Skjolding, Susanne Kruse, Sara Norgaard Sorensen, Rune Hjorth, Anders Baun
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Environmental Sciences
Rickard Arvidsson, Steffen Foss Hansen, Anders Baun
Article
Biochemistry & Molecular Biology
Emilie Da Silva, Chiara Autilio, Karin Sorig Hougaard, Anders Baun, Antonio Cruz, Jesus Perez-Gil, Jorid Birkelund Sorli
Summary: This study utilized various molecular and biophysical methods to investigate the effects of three chemicals known to cause acute inhalation toxicity on lung surfactant, demonstrating that these chemicals can disrupt lung surfactant surface activity.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Review
Environmental Sciences
Yue Zhi, Chuhui Zhang, Rune Hjorth, Anders Baun, Owen W. Duckworth, Douglas F. Call, Detlef R. U. Knappe, Jacob L. Jones, Khara Grieger
ENVIRONMENT INTERNATIONAL
(2020)
Article
Environmental Sciences
Tobias Lammel, Amalie Thit, Xianjin Cui, Catherine Mouneyrac, Anders Baun, Eugenia Valsami-Jones, Joachim Sturve, Henriette Selck
Summary: The study found that Cu-65 enriched CuO nanoparticles fed to fish resulted in significant amounts of Cu-65 in the feces, but no significant accumulation of Cu-65 in internal organs, except for a slight elevation in the liver. Gene expression analysis showed only metallothionein was significantly upregulated in intestinal tissue, while other genes remained unchanged. Overall, the results suggest limited dietary absorption efficiency of CuO NPs and minimal effects on Cu-related genes at low environmentally relevant exposure doses.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
L. M. Skjolding, L. vG. Jorgensen, K. S. Dyhr, C. J. Koppl, U. S. McKnight, P. Bauer-Gottwein, P. Mayer, P. L. Bjerg, A. Baun
Summary: Tracer tests are a well-established method for delineating key environmental processes, and this study provides ecotoxicity data for Rhodamine B and WT, showing that Rhodamine B is more toxic than Rhodamine WT. Therefore, read-across assessments using ecotoxicity data obtained with Rhodamine B is not advisable for estimating the ecotoxicity of Rhodamine WT.
Article
Environmental Sciences
Rickard Arvidsson, Gregory Peters, Steffen Foss Hansen, Anders Baun
Summary: This paper presents a further development and testing of an environmental risk screening method based on two proxy measures: aquatic ecotoxicity and global annual production volumes. The results show that only MXenes exhibit high aquatic ecotoxicity, while the other materials should continue to be monitored for their aquatic ecotoxicity data.
Editorial Material
Engineering, Environmental
Fazel Abdolahpur Monikh, Steffen Foss Hansen, Martina G. Vijver, Esther Kentin, Maria Bille Nielsen, Anders Baun, Kristian Syberg, Iseult Lynch, Eugenia Valsami-Jones, Willie J. G. M. Peijnenburg
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Steffen Foss Hansen, Rickard Arvidsson, Maria Bille Nielsen, Oliver Foss Hessner Hansen, Lauge Peter Westergaard Clausen, Anders Baun, Alessio Boldrin
Summary: The transition from a linear economy to a circular economy is gaining momentum, but there are significant challenges related to (eco-)toxicological hazards and the presence of nanomaterials in waste streams in utilizing nanotechnology for circularity.
NATURE NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Lars Michael Skjolding, Sara Norgaard Sorensen, Karen Scharling Dyhr, Rune Hjorth, Louise Schluter, Camilla Hedberg, Nanna B. Hartmann, Philipp Mayer, Anders Baun
Summary: This study presents two complementary approaches to account for shading in algal growth inhibition tests of engineered nanomaterials (ENMs) and colored substances. The first approach distinguishes between shading effects and toxicity, while the second approach addresses shading at the cellular level. The results indicate that toxicity rather than cellular shading dominates the response of algae exposed to ENMs.
Article
Chemistry, Multidisciplinary
Maria Bille Nielsen, Anders Baun, Aiga Mackevica, Amalie Thit, Inger Odnevall Wallinder, Julian Alberto Gallego, Lauge Peter Westergaard Clausen, Jenny Rissler, Lars Skjolding, Alejandra Castro Nilsson, Tommy Cedervall, Steffen Foss Hansen
Summary: The European Union has revised its chemical legislation to clarify technical data requirements for nanomaterials, with new provisions coming into effect from January 1, 2020. The study found that most of the information requirements and over 40% of the waiving criteria in the new REACH Annexes are supported by available methods. The study recommends further development of methods to fulfill the new regulatory requirements for physico-chemical characterisation and environmental fate and effects of nanomaterials.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Chemistry, Multidisciplinary
Chengfang Pang, Lars M. Skjolding, Henriette Selck, Anders Baun
Summary: The study found a low bioaccumulation potential of nano-CuPc in freshwater organisms, indicating limited entry from sediment into the benthic food web. Nano-CuPc showed relatively high attachment to algae, but insignificant accumulation in crustaceans and snails after exposure. These results suggest that nano-CuPc mainly remains in water and sediments rather than being bioaccumulated by aquatic organisms.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Chemistry, Multidisciplinary
Tobias Lammel, Amalie Thit, Xianjin Cui, Catherine Mouneyrac, Anders Baun, Eugenia Valsami-Jones, Joachim Sturve, Henriette Selck
ENVIRONMENTAL SCIENCE-NANO
(2020)
