Journal
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
Volume 783, Issue -, Pages 9-14Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrfmmm.2015.12.002
Keywords
Zinc finger nuclease (ZFN); DNA double-strand break (DSB) repair; H2AX; Small RNA; Arabidopsis thaliana
Funding
- National Science Foundation [MCB 0209818, DBI 0923827]
- National Science Foundation of China [31271420, 31330017]
- National Transgenic Major Project [2014ZX0801003B-002]
- East Carolina University
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Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana. Published by Elsevier B.V.
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