Structure-function analysis of the heme-binding WWD domain in the bacterial holocytochrome c synthase, CcmFH

Architecture of the Heme-translocating CcmABCD/E complex required for Cytochrome c maturation

(2023) Lorena Ilcu et al.   Nature Communications

AF2Complex predicts direct physical interactions in multimeric proteins with deep learning

(2022) Mu Gao et al.   Nature Communications

Structures of the CcmABCD heme release complex at multiple states

(2022) Jiao Li et al.   Nature Communications

UniProt: the Universal Protein Knowledgebase in 2023

(2022) et al.   NUCLEIC ACIDS RESEARCH

Architecture of the membrane-bound cytochrome c heme lyase CcmF

(2021) Anton Brausemann et al.   Nature Chemical Biology

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport

(2021) Deanna L. Mendez et al.   Nature Chemical Biology

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

A Cytoplasmic Heme Sensor Illuminates the Impacts of Mitochondrial and Vacuolar Functions and Oxidative Stress on Heme-Iron Homeostasis in Cryptococcus neoformans

(2020) Gaurav Bairwa et al.   mBio

Structurally Mapping Endogenous Heme in the CcmCDE Membrane Complex for Cytochrome c Biogenesis

(2018) Molly C. Sutherland et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase

(2018) Molly C. Sutherland et al.   mBio

The thioreduction component CcmG confers efficiency and the heme ligation component CcmH ensures stereo-specificity during cytochrome c maturation

(2017) Andreia F. Verissimo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of labile heme in live malaria parasites using a genetically encoded biosensor

(2017) James R. Abshire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maturation of Plastid c-type Cytochromes

(2017) Stéphane T. Gabilly et al.   Frontiers in Plant Science

Heme Trafficking and Modifications during System I Cytochrome c Biogenesis: Insights from Heme Redox Potentials of Ccm Proteins

(2016) Molly C. Sutherland et al.   BIOCHEMISTRY

Regulation of intracellular heme trafficking revealed by subcellular reporters

(2016) Xiaojing Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors

(2016) David A. Hanna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetically Encoded FRET Sensor for Intracellular Heme

(2015) Yanqun Song et al.   ACS Chemical Biology

Mitochondrial cytochrome c biogenesis: no longer an enigma

(2015) Shalon E. Babbitt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cytochrome c biogenesis System I: An intricate process catalyzed by a maturase supercomplex?

(2014) Andreia F. Verissimo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The CcmFH complex is the system I holocytochromecsynthetase: engineering cytochromecmaturation independent of CcmABCDE

(2014) Brian San Francisco et al.   MOLECULAR MICROBIOLOGY

Probing Heme Delivery Processes in Cytochrome c Biogenesis System I

(2013) Despoina A. I. Mavridou et al.   BIOCHEMISTRY

Recognition and binding of apocytochrome c to P. aeruginosa CcmI, a component of cytochrome c maturation machinery

(2013) Eva Di Silvio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Interaction of HoloCcmE with CcmF in Heme Trafficking and Cytochrome c Biosynthesis

(2013) Brian San Francisco et al.   JOURNAL OF MOLECULAR BIOLOGY

Heme Ligand Identification and Redox Properties of the CytochromecSynthetase, CcmF

(2011) Brian San Francisco et al.   BIOCHEMISTRY

Composition and function of cytochrome c biogenesis System II

(2011) Jörg Simon et al.   FEBS Journal

CcmI Subunit of CcmFHI Heme Ligation Complex Functions as an ApocytochromecChaperone duringc-Type Cytochrome Maturation

(2011) Andreia F. Verissimo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CcmC:Heme:CcmE Complex in Heme Trafficking and Cytochrome c Biosynthesis

(2010) Cynthia Richard-Fogal et al.   JOURNAL OF MOLECULAR BIOLOGY

Essential histidine pairs indicate conserved haem binding in epsilonproteobacterial cytochrome c haem lyases

(2010) M. Kern et al.   MICROBIOLOGY-SGM

Cytochrome c biogenesis: the Ccm system

(2010) Carsten Sanders et al.   TRENDS IN MICROBIOLOGY

A conserved haem redox and trafficking pathway for cofactor attachment

(2009) Cynthia L Richard-Fogal et al.   EMBO JOURNAL

Cytochrome c Biogenesis: Mechanisms for Covalent Modifications and Trafficking of Heme and for Heme-Iron Redox Control

(2009) R. G. Kranz et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

CcsBA is a cytochrome c synthetase that also functions in heme transport

(2009) E. R. Frawley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical requirements for the maturation of mitochondrial c-type cytochromes

(2008) Patrice Hamel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Three Mitochondrial Encoded CcmF Proteins Form a Complex That Interacts with CCMH andc-Type Apocytochromes inArabidopsis

(2008) Naganand Rayapuram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CytochromecMaturation Components CcmF, CcmH, and CcmI Form a Membrane-integral Multisubunit Heme Ligation Complex

(2008) Carsten Sanders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compensatory thio-redox interactions between DsbA, CcdA and CcmG unveil the apocytochrome c holdase role of CcmG during cytochromecmaturation

(2008) Serdar Turkarslan et al.   MOLECULAR MICROBIOLOGY