The main bioactive compound of Panax notoginseng, notoginsenoside R1, alleviates pulmonary fibrosis via MBD2/SHIP and STAT3 pathway

Geniposide improves bleomycin-induced pulmonary fibrosis by inhibiting NLRP3 inflammasome activation and modulating metabolism

(2023) Yi Wei et al.   Journal of Functional Foods

Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-κB/TGF-β1 signaling

(2022) Savita Verma et al.   PHYTOMEDICINE

MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program

(2021) Yi Wang et al.   Science Advances

Macrophages in Lung Injury, Repair, and Fibrosis

(2021) Peiyong Cheng et al.   Cells

TGF‑β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review)

(2021) Zhimin Ye et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of Nervilia fordii Extract on Pulmonary Fibrosis Through TGF-β/Smad Signaling Pathway

(2021) Yufeng Yao et al.   Frontiers in Pharmacology

Xuanfei Baidu Decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibiting IL-6/STAT3 signaling pathway

(2021) Yuying Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Notoginsenoside R1 alleviates the inflammation of osteoarthritis by activating the Nrf2/HO-1 signalling pathway in vitro and in vivo

(2021) Ming Chen et al.   Journal of Functional Foods

Network Pharmacology-Based Investigation and Experimental Exploration of the Antiapoptotic Mechanism of Colchicine on Myocardial Ischemia Reperfusion Injury

(2021) Yuanjun Tang et al.   Frontiers in Pharmacology

Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases

(2020) Hai Liu et al.   Drug Design Development and Therapy

Steamed Panax notoginseng Attenuates Anemia in Mice With Blood Deficiency Syndrome via Regulating Hematopoietic Factors and JAK-STAT Pathway

(2020) Zejun Zhang et al.   Frontiers in Pharmacology

Traditional uses, chemical diversity and biological activities of Panax L. (Araliaceae): A review

(2020) Lu Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts

(2019) David W Waters et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting SOCS Proteins to Control JAK-STAT Signalling in Disease

(2019) Gillian A. Durham et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pentagalloylglucose inhibits the replication of rabies virus via mediating the miR-455/SOCS3/STAT3/IL-6 pathway

(2019) Zhongzhong Tu et al.   JOURNAL OF VIROLOGY

Shared and distinct mechanisms of fibrosis

(2019) Jörg H. W. Distler et al.   Nature Reviews Rheumatology

Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats

(2019) Sana Bahri et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Macrophages: Their role, activation and polarization in pulmonary diseases

(2018) Shweta Arora et al.   IMMUNOBIOLOGY

Metformin reverses established lung fibrosis in a bleomycin model

(2018) Sunad Rangarajan et al.   NATURE MEDICINE

Readers of DNA methylation, the MBD family as potential therapeutic targets

(2018) Gordon D. Ginder et al.   PHARMACOLOGY & THERAPEUTICS

Macrophages in inflammation, repair and regeneration

(2018) Yumiko Oishi et al.   INTERNATIONAL IMMUNOLOGY

Identifying Barriers to Idiopathic Pulmonary Fibrosis Treatment: A Survey of Patient and Physician Views

(2018) Toby M. Maher et al.   RESPIRATION

M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis

(2018) Jiwei Hou et al.   Cell Communication and Signaling

Unmet needs in the treatment of idiopathic pulmonary fibrosis―insights from patient chart review in five European countries

(2017) Toby M. Maher et al.   BMC Pulmonary Medicine

Interferon alpha antagonizes STAT3 and SOCS3 signaling triggered by hepatitis C virus

(2016) Lan-Juan Zhao et al.   CYTOKINE

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Immunotherapeutic implications of IL-6 blockade for cytokine storm

(2016) Toshio Tanaka et al.   Immunotherapy

Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review

(2016) Ting Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

(2016) Subrata Kumar Biswas   Oxidative Medicine and Cellular Longevity

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

(2016) Tetsuya Kimura et al.   Nature Communications

Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions

(2015) Veronica Della Latta et al.   PHARMACOLOGICAL RESEARCH

miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program

(2015) Shicheng Su et al.   Nature Communications

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY