Multiple sclerosis should be treated using a step-down strategy rather than a step-up strategy–NO

Defining high, medium and low impact prognostic factors for developing multiple sclerosis

(2015) Mar Tintore et al.   BRAIN

Using MRI to make informed clinical decisions in multiple sclerosis care

(2015) Robert A. Bermel et al.   CURRENT OPINION IN NEUROLOGY

Randomized study combining interferon and glatiramer acetate in multiple sclerosis

(2013) Fred D. Lublin et al.   ANNALS OF NEUROLOGY

Long-term impact of interferon beta-1b in patients with CIS: 8-year follow-up of BENEFIT

(2013) G. Edan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Effects of early treatment with glatiramer acetate in patients with clinically isolated syndrome

(2012) Giancarlo Comi et al.   Multiple Sclerosis Journal

Association Between Immediate Initiation of Intramuscular Interferon Beta-1a at the Time of a Clinically Isolated Syndrome and Long-term Outcomes

(2011) R. Philip Kinkel   ARCHIVES OF NEUROLOGY