Septo-hippocampal dynamics and the encoding of space and time

All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

(2023) Linlin Z. Fan et al.   CELL

Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes

(2023) Guillaume Etter et al.   Nature Communications

Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus

(2023) Andrew S. Alexander et al.   HIPPOCAMPUS

Dynamic synchronization between hippocampal representations and stepping

(2023) Abhilasha Joshi et al.   NATURE

Consistent population activity on the scale of minutes in the mouse hippocampus

(2022) Yue Liu et al.   HIPPOCAMPUS

Complementary representations of time in the prefrontal cortex and hippocampus

(2022) Wing Ning et al.   HIPPOCAMPUS

Huygens synchronization of medial septal pacemaker neurons generates hippocampal theta oscillation

(2022) Barnabás Kocsis et al.   Cell Reports

Theta oscillations support active exploration in human spatial navigation

(2022) Elizabeth R. Chrastil et al.   NEUROIMAGE

Temporal dynamics of cholinergic activity in the septo-hippocampal system

(2022) Jeffrey D. Kopsick et al.   Frontiers in Neural Circuits

Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons

(2022) Lorenza Magno et al.   Communications Biology

Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity

(2022) Sweyta Lohani et al.   NATURE NEUROSCIENCE

Two septal-entorhinal GABAergic projections differentially control coding properties of spatially tuned neurons in the medial entorhinal cortex

(2021) Magdalene Isabell Schlesiger et al.   Cell Reports

Scalable representation of time in the hippocampus

(2021) Akihiro Shimbo et al.   Science Advances

Scopolamine Impairs Spatial Information Recorded With “Miniscope” Calcium Imaging in Hippocampal Place Cells

(2021) Dechuan Sun et al.   Frontiers in Neuroscience

Optogenetic pacing of medial septum parvalbumin-positive cells disrupts temporal but not spatial firing in grid cells

(2021) Mikkel Elle Lepperød et al.   Science Advances

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts

(2021) Xiaojie Gao et al.   Nature Communications

5-HT modulation of a medial septal circuit tunes social memory stability

(2021) Xiaoting Wu et al.   NATURE

Precisely timed theta oscillations are selectively required during the encoding phase of memory

(2021) Clare R. Quirk et al.   NATURE NEUROSCIENCE

Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus

(2021) Xinyu Zhao et al.   NEURON

Theta rhythmicity governs human behavior and hippocampal signals during memory-dependent tasks

(2021) Marije ter Wal et al.   Nature Communications

Phasic modulation of hippocampal synaptic plasticity by theta rhythm.

(2020) L. Stan Leung et al.   BEHAVIORAL NEUROSCIENCE

Synaptic organisation and behaviour-dependent activity of mGluR8a-innervated GABAergic trilaminar cells projecting from the hippocampus to the subiculum

(2020) Linda Katona et al.   Brain Structure & Function

Changing phase relationship of the stepping rhythm to neuronal oscillatory theta activity in the septo-hippocampal network of mice

(2020) Abhilasha Joshi et al.   Brain Structure & Function

Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus

(2020) Kenneth Kay et al.   CELL

Entorhinal velocity signals reflect environmental geometry

(2020) Robert G. K. Munn et al.   NATURE NEUROSCIENCE

Egocentric boundary vector tuning of the retrosplenial cortex

(2020) Andrew S. Alexander et al.   Science Advances

The Firing of Theta State-Related Septal Cholinergic Neurons Disrupt Hippocampal Ripple Oscillations via Muscarinic Receptors

(2020) Xiaoyu Ma et al.   JOURNAL OF NEUROSCIENCE

Trajectory-modulated hippocampal neurons persist throughout memory-guided navigation

(2020) Nathaniel R. Kinsky et al.   Nature Communications

Hippocampal spatial memory representations in mice are heterogeneously stable

(2020) Samuel J. Levy et al.   HIPPOCAMPUS

An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

(2020) Miao Jing et al.   NATURE METHODS

Vector trace cells in the subiculum of the hippocampal formation

(2020) Steven Poulter et al.   NATURE NEUROSCIENCE

Effects of visual inputs on neural dynamics for coding of location and running speed in medial entorhinal cortex

(2020) Holger Dannenberg et al.   eLife

Theta rhythm supports hippocampus-dependent integrative encoding in schematic/semantic memory networks

(2020) Berta Nicolás et al.   NEUROIMAGE

Place cell assemblies remain intact, despite reduced phase precession, after cholinergic disruption

(2019) Sarah Jo C. Venditto et al.   HIPPOCAMPUS

GABAergic medial septal neurons with low-rhythmic firing innervating the dentate gyrus and hippocampal area CA3

(2019) Minas Salib et al.   JOURNAL OF NEUROSCIENCE

Neuronal representation of environmental boundaries in egocentric coordinates

(2019) James R. Hinman et al.   Nature Communications

A sense of space in postrhinal cortex

(2019) Patrick A. LaChance et al.   SCIENCE

The Same Hippocampal CA1 Population Simultaneously Codes Temporal Information over Multiple Timescales

(2018) William Mau et al.   CURRENT BIOLOGY

Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies

(2018) Ipshita Zutshi et al.   CURRENT BIOLOGY

Experience-dependent trends in CA1 theta and slow gamma rhythms in freely behaving mice

(2018) Brian J. Gereke et al.   JOURNAL OF NEUROPHYSIOLOGY

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

(2018) Miao Jing et al.   NATURE BIOTECHNOLOGY

Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum

(2018) Tim James Viney et al.   eLife

Neurophysiological signatures of temporal coordination between retrosplenial cortex and the hippocampal formation.

(2018) Andrew S. Alexander et al.   BEHAVIORAL NEUROSCIENCE

A neural-level model of spatial memory and imagery

(2018) Andrej Bicanski et al.   eLife

An Optimal Oscillatory Phase for Pattern Reactivation during Memory Retrieval

(2018) Casper Kerrén et al.   CURRENT BIOLOGY

Nested sequences of hippocampal assemblies during behavior support subsequent sleep replay

(2018) Céline Drieu et al.   SCIENCE

Behavior-dependent activity patterns of GABAergic long-range projecting neurons in the rat hippocampus

(2017) Linda Katona et al.   HIPPOCAMPUS

Electrophysiological Evidence That the Retrosplenial Cortex Displays a Strong and Specific Activation Phased with Hippocampal Theta during Paradoxical (REM) Sleep

(2017) Bruna Del Vechio Koike et al.   JOURNAL OF NEUROSCIENCE

Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area

(2017) Abhilasha Joshi et al.   NEURON

Behavioral time scale synaptic plasticity underlies CA1 place fields

(2017) Katie C. Bittner et al.   SCIENCE

Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation

(2017) Véronique D. Bohbot et al.   Nature Communications

Modulating medial septal cholinergic activity reduces medial entorhinal theta frequency without affecting speed or grid coding

(2017) Francis Carpenter et al.   Scientific Reports

NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory

(2017) Lorenza Magno et al.   Cell Reports

Ten Years of Grid Cells

(2016) David C. Rowland et al.   Annual Review of Neuroscience

Optogenetic Activation of Septal Glutamatergic Neurons Drive Hippocampal Theta Rhythms

(2016) J. Robinson et al.   JOURNAL OF NEUROSCIENCE

Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections

(2016) Daniel Justus et al.   NATURE NEUROSCIENCE

Rebound spiking in layer II medial entorhinal cortex stellate cells: Possible mechanism of grid cell function

(2016) Christopher F. Shay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Local and Distant Input Controlling Excitation in Layer II of the Medial Entorhinal Cortex

(2016) Elke C. Fuchs et al.   NEURON

Multiple Running Speed Signals in Medial Entorhinal Cortex

(2016) James R. Hinman et al.   NEURON

Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation

(2016) R. Boyce et al.   SCIENCE

Theta–gamma coupling in the entorhinal–hippocampal system

(2015) Laura Lee Colgin   CURRENT OPINION IN NEUROBIOLOGY

Synergy of Direct and Indirect Cholinergic Septo-Hippocampal Pathways Coordinates Firing in Hippocampal Networks

(2015) H. Dannenberg et al.   JOURNAL OF NEUROSCIENCE

Synaptic Targets of Medial Septal Projections in the Hippocampus and Extrahippocampal Cortices of the Mouse

(2015) G. Unal et al.   JOURNAL OF NEUROSCIENCE

Speed cells in the medial entorhinal cortex

(2015) Emilio Kropff et al.   NATURE

The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity

(2015) Magdalene I Schlesiger et al.   NATURE NEUROSCIENCE

During Running in Place, Grid Cells Integrate Elapsed Time and Distance Run

(2015) Benjamin J. Kraus et al.   NEURON

Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit

(2015) Falko Fuhrmann et al.   NEURON

Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway

(2015) Franziska Bender et al.   Nature Communications

Grid cell spatial tuning reduced following systemic muscarinic receptor blockade

(2014) Ehren L. Newman et al.   HIPPOCAMPUS

GABAergic Projections from the Medial Septum Selectively Inhibit Interneurons in the Medial Entorhinal Cortex

(2014) A. Gonzalez-Sulser et al.   JOURNAL OF NEUROSCIENCE

Medial Septum-Diagonal Band of Broca (MSDB) GABAergic Regulation of Hippocampal Acetylcholine Efflux Is Dependent on Cognitive Demands

(2014) J. J. Roland et al.   JOURNAL OF NEUROSCIENCE

Theta sequences are essential for internally generated hippocampal firing fields

(2014) Yingxue Wang et al.   NATURE NEUROSCIENCE

New and Distinct Hippocampal Place Codes Are Generated in a New Environment during Septal Inactivation

(2014) Mark P. Brandon et al.   NEURON

Optogenetic activation of septal cholinergic neurons suppresses sharp wave ripples and enhances theta oscillations in the hippocampus

(2014) Marie Vandecasteele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus

(2014) Joshua H Siegle et al.   eLife

Phase coding by grid cells in unconstrained environments: two-dimensional phase precession

(2013) Jason R. Climer et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cholinergic Blockade Reduces Theta-Gamma Phase Amplitude Coupling and Speed Modulation of Theta Frequency Consistent with Behavioral Effects on Encoding

(2013) E. L. Newman et al.   JOURNAL OF NEUROSCIENCE

Distinct Hippocampal Time Cell Sequences Represent Odor Memories in Immobilized Rats

(2013) C. J. MacDonald et al.   JOURNAL OF NEUROSCIENCE

Evidence for Encoding versus Retrieval Scheduling in the Hippocampus by Theta Phase and Acetylcholine

(2013) V. Douchamps et al.   JOURNAL OF NEUROSCIENCE

Segregation of cortical head direction cell assemblies on alternating theta cycles

(2013) Mark P Brandon et al.   NATURE NEUROSCIENCE

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

(2013) György Buzsáki et al.   NATURE NEUROSCIENCE

Hippocampal “Time Cells”: Time versus Path Integration

(2013) Benjamin J. Kraus et al.   NEURON

Theta phase precession of grid and place cell firing in open environments

(2013) A. Jeewajee et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Theta Coordinated Error-Driven Learning in the Hippocampus

(2013) Nicholas Ketz et al.   PLoS Computational Biology

The entorhinal grid map is discretized

(2012) Hanne Stensola et al.   NATURE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Reduction of Theta Rhythm Dissociates Grid Cell Spatial Periodicity from Directional Tuning

(2011) M. P. Brandon et al.   SCIENCE

The Spatial Periodicity of Grid Cells Is Not Sustained During Reduced Theta Oscillations

(2011) J. Koenig et al.   SCIENCE

Theta Modulation in the Medial and the Lateral Entorhinal Cortices

(2010) Sachin S. Deshmukh et al.   JOURNAL OF NEUROPHYSIOLOGY

Glutamatergic Neurons of the Mouse Medial Septum and Diagonal Band of Broca Synaptically Drive Hippocampal Pyramidal Cells: Relevance for Hippocampal Theta Rhythm

(2010) C. Y. L. Huh et al.   JOURNAL OF NEUROSCIENCE

Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum

(2009) Colin Lever et al.   HIPPOCAMPUS

Knock-Out of HCN1 Subunit Flattens Dorsal-Ventral Frequency Gradient of Medial Entorhinal Neurons in Adult Mice

(2009) L. M. Giocomo et al.   JOURNAL OF NEUROSCIENCE

Boundary Vector Cells in the Subiculum of the Hippocampal Formation

(2009) C. Lever et al.   JOURNAL OF NEUROSCIENCE

Grid cells and theta as oscillatory interference: Theory and predictions

(2008) Neil Burgess   HIPPOCAMPUS

Influence of boundary removal on the spatial representations of the medial entorhinal cortex

(2008) Francesco Savelli et al.   HIPPOCAMPUS

Grid cells and theta as oscillatory interference: Electrophysiological data from freely moving rats

(2008) A. Jeewajee et al.   HIPPOCAMPUS

The Hippocamposeptal Pathway Generates Rhythmic Firing of GABAergic Neurons in the Medial Septum and Diagonal Bands: An Investigation Using a Complete Septohippocampal Preparation In Vitro

(2008) F. Manseau et al.   JOURNAL OF NEUROSCIENCE

The presence of pacemaker HCN channels identifies theta rhythmic GABAergic neurons in the medial septum

(2008) Viktor Varga et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hippocampus-independent phase precession in entorhinal grid cells

(2008) Torkel Hafting et al.   NATURE

Representation of Geometric Borders in the Entorhinal Cortex

(2008) Trygve Solstad et al.   SCIENCE

Internally Generated Cell Assembly Sequences in the Rat Hippocampus

(2008) E. Pastalkova et al.   SCIENCE

Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations

(2008) T. Klausberger et al.   SCIENCE