The ATG16L1 risk allele associated with Crohn’s disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

TheATG16L1–T300Aallele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients

(2014) Mehdi Sadaghian Sadabad et al.   GUT

VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease

(2014) Silvia D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of p21Rac Signaling and Increased Innate Immunity Mediate Remission in Crohn's Disease

(2014) K. Parikh et al.   Science Translational Medicine

ATG16L1andNOD2polymorphisms enhance phagocytosis in monocytes of Crohn’s disease patients

(2014) Simone CS Wolfkamp   WORLD JOURNAL OF GASTROENTEROLOGY

The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues

(2014) Anna-Karin E. Johnsson et al.   Cell Reports

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

(2013) M. Nobis et al.   CANCER RESEARCH

The TBC/RabGAP Armus Coordinates Rac1 and Rab7 Functions during Autophagy

(2013) Bernadette Carroll et al.   DEVELOPMENTAL CELL

Wiskott–Aldrich Syndrome Protein Deficiency in Innate Immune Cells Leads to Mucosal Immune Dysregulation and Colitis in Mice

(2012) Deanna D. Nguyen et al.   GASTROENTEROLOGY

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

(2012) Manon E. Wildenberg et al.   GASTROENTEROLOGY

Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion

(2012) Young Mi Park et al.   MOLECULAR BIOLOGY OF THE CELL

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

Adaptive T-cell responses regulating oral tolerance to protein antigen

(2010) M. F. du Pré et al.   ALLERGY

Deletion of ABCA1 and ABCG1 Impairs Macrophage Migration Because of Increased Rac1 Signaling

(2010) Tamara A. Pagler et al.   CIRCULATION RESEARCH

Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

(2010) M. Nethe et al.   JOURNAL OF CELL SCIENCE

Spatio-temporal Rho GTPase signaling - where are we now?

(2010) O. Pertz   JOURNAL OF CELL SCIENCE

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

(2010) Jean Frédéric Colombel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort

(2009) Rinse K Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

(2008) P. K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA