Article
Clinical Neurology
Edzard Schwedhelm, Catrin Englisch, Louisa Niemann, Susanne Lezius, Mirjam von Lucadou, Kristina Marmann, Rainer Boeger, Sven Peine, Guenter Daum, Christian Gerloff, Chi-un Choe
Summary: The study found that Parkinson's disease patients have lower serum S1P levels compared to controls, and lower S1P concentrations are associated with more severe motor symptoms and faster motor decline in PD patients, but not with cognitive decline.
MOVEMENT DISORDERS
(2021)
Article
Geriatrics & Gerontology
Bei Xu, Xin Wang, Jifeng Guo, Huizhuo Xu, Beisha Tang, Bin Jiao, Lu Shen
Summary: The present study used OCTA to evaluate retinal microvascular variations in patients with PD at different clinical stages. The results showed that there were significant reductions in macular vessel density, peripapillary vessel density, and foveal avascular zone area in the PD groups compared to the healthy controls. These changes were also found to be correlated with clinical parameters. OCTA may serve as a valuable tool for monitoring the progression of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Shulei He, Lu Huang, Ci Shao, Tiejian Nie, Li Xia, Bozhou Cui, Fangfang Lu, Lin Zhu, Bolin Chen, Qian Yang
Summary: This study identified 6 serum EV-derived miRNAs that may serve as potential biomarkers for PD progression and early diagnosis in populations, demonstrating their potential clinical utility.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Clinical Neurology
Frida Hjalte, Jenny M. Norlin, Klas Kellerborg, Per Odin
Summary: The study estimated resource use and costs in relation to severity levels in individuals with Parkinson's disease in a Swedish setting, showing that late stages of the disease were associated with significant societal costs. The findings suggest potential savings by optimizing symptomatic treatment for patients with advanced PD.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Geriatrics & Gerontology
Yuling Wang, Hua Gao, Sen Jiang, Qin Luo, Xuejie Han, Yi Xiong, Zeheng Xu, Rui Qiao, Xinling Yang
Summary: This study found that peripheral blood disorders may be associated with the risk of Parkinson's disease (PD), but not with the severity of PD, after analyzing blood data from PD patients and controls. Principal component analysis helped reduce data dimensionality and identified potential associations between certain blood values/ratios and PD risk.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Health Care Sciences & Services
Emmie Cohen, Allison A. Bay, Liang Ni, Madeleine E. Hackney
Summary: Apathy is often overlooked in Parkinson's Disease (PD) but can have a negative impact on quality of life and increase with disease severity. Early identification of apathy can aid in treatment and improve prognosis.
Article
Clinical Neurology
Xiaodi Fu, Wenbin Deng, Xiangqin Cui, Xiao Zhou, Weizheng Song, Mengqiu Pan, Xiao Chi, Jinghui Xu, Ying Jiang, Qun Wang, Yunqi Xu
Summary: The study revealed that iron content in various gray matter nuclei in PD patients varies with disease progression and is associated with clinical symptoms. Iron deposition in SN and GP gradually increases in the early stage of PD, while it is not significant in advanced stage patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Junli Li, Haiyan Liao, Tianyu Wang, Yuheng Zi, Lin Zhang, Min Wang, Zhenni Mao, ChenDie Song, Fan Zhou, Qin Shen, Sainan Cai, Changlian Tan
Summary: This study investigated alterations in regional homogeneity in early Parkinson's disease at different Hoehn and Yahr stages, revealing different patterns of brain function and potential differential indicators for mild and moderate PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Clinical Neurology
Carsten Buhmann, Tim Magnus, Chi-un Choe
Summary: Blood neurofilament light chain (NfL) is a viable biomarker for neuroaxonal damage in Parkinson's disease (PD) that shows high sensitivity and specificity in distinguishing idiopathic PD from atypical parkinsonian syndromes (APS). Studies have found significant correlations between blood NfL and motor and cognitive function, as well as consistent associations between baseline blood NfL and motor progression and cognitive worsening. Blood NfL has potential as a biomarker in predicting disease severity and progression in PD patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Medicine, General & Internal
Jiali Su, Yidong Deng, Benchi Cai, Si Teng, Shan Zhang, Yanhui Liu, Jie Lin, Qiang Yang, Danting Zeng, Xiuying Zhao, Tao Chen
Summary: This study found that Parkinson's disease patients have elevated serum levels of PI3K, which are associated with disease severity, disease duration, and cognitive impairment. However, there were no significant differences in PI3K SNPs between patients with normal cognitive function and those with cognitive impairment.
Article
Clinical Neurology
Monika Poetter-Nerger, Janina Dutke, Susanne Lezius, Carsten Buhmann, Robert Schulz, Christian Gerloff, Jens Kuhle, Chi-un Choe
Summary: This study found that increased serum neurofilament light chain (NfL) levels were associated with PIGD subtype and PIGD scores in patients with advanced Parkinson's disease.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Clinical Neurology
Roberta Bovenzi, Matteo Conti, Giulia Rebecca Degoli, Rocco Cerroni, Clara Simonetta, Claudio Liguori, Chiara Salimei, Antonio Pisani, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Tommaso Schirinzi
Summary: This article examines the clinical presentation and progression of early-onset Parkinson's disease (EOPD). The results show that EOPD primarily manifests as an asymmetric, rigid-akinetic motor syndrome. The study also found that the disease gradually progresses over a 10-year period and is influenced by gender.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Louisa Niemann, Susanne Lezius, Aleksandra Maceski, David Leppert, Catrin Englisch, Edzard Schwedhelm, Tanja Zeller, Christian Gerloff, Jens Kuhle, Chi-un Choe
Summary: In advanced PD patients, serum NfL concentrations are associated with motor function, cognitive decline, and subclinical cardiac damage.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Immunology
Alexi Nott, Inge R. Holtman
Summary: Microglia, as the macrophages in the brain, play a vital role in brain homeostasis and are implicated in various brain disorders. Neuroinflammation has emerged as a potential therapeutic target for neurodegeneration, but the specific function of microglia in different neurodegenerative disorders is still being actively studied.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Genetics & Heredity
Inas Elsayed, Alejandro Martinez-Carrasco, Mario Cornejo-Olivas, Sara Bandres-Ciga
Summary: Genetics has played a key role in uncovering the etiology of Parkinson's disease, but there is a need for more representation of non-European populations in research to address existing gaps in knowledge of genetic differences. Overcoming this challenge will provide novel insights into the disease's genetic architecture and improve understanding across diverse populations. Collaborative global initiatives are shaping the future of PD genetics, highlighting the importance of inclusivity and diversity in research efforts.
Article
Geriatrics & Gerontology
Victoria Berge-Seidl, Lasse Pihlstrom, Zbigniew K. Wszolek, Owen A. Ross, Mathias Toft
NEUROBIOLOGY OF AGING
(2019)
Letter
Genetics & Heredity
Zafar Iqbal, Mathias Toft
Article
Multidisciplinary Sciences
Bezhod Tashbayev, Tor Paaske Utheim, Oygunn Aass Utheim, Sten Raeder, Janicke Liaaen Jensen, Mazyar Yazdani, Neil Lagali, Valeria Vitelli, Darlene A. Dartt, Xiangjun Chen
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Silje Bjerknes, Inger Marie Skogseid, Tuva Jin Hauge, Espen Dietrichs, Mathias Toft
NPJ PARKINSONS DISEASE
(2020)
Article
Multidisciplinary Sciences
Victoria Berge-Seidl, Lasse Pihlstrom, Mathias Toft
Summary: Genome-wide association studies have identified genetic risk signals for Parkinson's disease, with potential biological mechanisms yet to be fully understood. Utilizing genomic functional annotations, researchers found an overlap between PD risk variants and open chromatin regions in neurons, particularly in the superior temporal cortex. This suggests that cortical neurons may play a key role in mediating genetic risk for PD, implicating transcriptional networks involving basic Helix-Loop-Helix transcription factors.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Mazyar Yazdani, Jorgen Fiskadal, Xiangjun Chen, Oygunn A. Utheim, Sten Raeder, Valeria Vitelli, Tor P. Utheim
Summary: The study found that tear film break-up time can effectively differentiate pathological scores for other clinical tests and is associated with other parameters. Significant differences were observed between parameters at different TFBUT levels, with OPI showing the strongest discriminative power and association with TFBUT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Fredrik Fineide, Xiangjun Chen, Thomas Bjellaas, Valeria Vitelli, Tor Paaske Utheim, Janicke Liaaen Jensen, Hilde Kanli Galtung
Summary: The study revealed significant differences in the lipidomic profiles of saliva and tears in pSS patients compared to healthy controls, with individual lipid species in stimulated saliva showing similarities to glandular biopsies. This opens up intriguing avenues for further research and may lead to innovative diagnostic methodologies and treatment modalities for alleviating pSS-related sicca symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Kristin E. Wickstrom, Valeria Vitelli, Ewan Carr, Aleksander R. Holten, Rebecca Bendayan, Andrew H. Reiner, Daniel Bean, Tom Searle, Anthony Shek, Zeljko Kraljevic, James Teo, Richard Dobson, Kristian Tonby, Alvaro Kohn-Luque, Erik K. Amundsen
Summary: This study validated prediction models for hospitalized COVID-19 patients, showing variable performance with the Xie model having the best discrimination for mortality.
Article
Clinical Neurology
Silje Bjerknes, Mathias Toft, Reidun Brandt, Trine Waage Rygvold, Ane Konglund, Espen Dietrichs, Stein Andersson, Inger Marie Skogseid
Summary: The study found that patients with Parkinson's disease who underwent STN-DBS treatment showed significant improvement in motor and non-motor symptoms, but a decline in cognitive function, especially in verbal fluency and executive function. Patients mapped with multiple microelectrode recordings had better outcomes in some aspects but also experienced more decline in verbal fluency. Older age was identified as the main factor associated with physical dependence after long-term treatment.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Nursing
Kristin Jeppestol, Valeria Vitelli, Marit Kirkevold, Line K. Bragstad
Summary: This study explores the care trajectories of older home nursing care patients following acute functional decline, and identifies age, living environment, and early warning scores as important factors influencing clinical response and final level of care.
HOME HEALTH CARE MANAGEMENT AND PRACTICE
(2022)
Article
Clinical Neurology
Chiara Cappelletti, Sandra Pilar Henriksen, Hanneke Geut, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg, Lasse Pihlstrom, Mathias Toft
Summary: This study identified disease stage-specific transcriptomic changes in Parkinson's disease, with early stage showing specific gene expression changes in brain-specific pathways and immune mechanisms. The study also found that mitochondrial mechanisms are enriched throughout the disease course. Furthermore, several poorly characterized long non-coding RNAs were implicated in disease development and progression, and two candidate genes for future functional studies were highlighted.
ACTA NEUROPATHOLOGICA
(2023)
Article
Genetics & Heredity
Saadia Maryam Saadi, Elisa Cali, Lubaba Bintee Khalid, Hammad Yousaf, Ghazala Zafar, Haq Nawaz Khan, Muhammad Sher, Barbara Vona, Uzma Abdullah, Naveed Altaf Malik, Joakim Klar, Stephanie Efthymiou, Niklas Dahl, Henry Houlden, Mathias Toft, Shahid Mahmood Baig, Ambrin Fatima, Zafar Iqbal
Summary: The objective of this study is to identify the genetic causes of rare spinocerebellar disorders in the Pakistani population. Whole exome sequencing was used to investigate nine consanguineous families, resulting in the identification of six novel pathogenic variants and three already reported pathogenic variants. This study expands the mutation spectrum of rare spinocerebellar disorders and highlights the usefulness of next-generation sequencing in combination with clinical investigation for better diagnosis.
Article
Clinical Neurology
I. S. Brorson, A. M. Eriksson, I. S. Leikfoss, V. Vitelli, E. G. Celius, T. Luders, T. Berge, H. F. Harbo, H. Nilsen, S. D. Bos
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2020)
Article
Biology
Arne V. Pladsen, Gro Nilsen, Oscar M. Rueda, Miriam R. Aure, Ornulf Borgan, Knut Liestol, Valeria Vitelli, Arnoldo Frigessi, Anita Langerod, Anthony Mathelier, Olav Engebraten, Vessela Kristensen, David C. Wedge, Peter Van Loo, Carlos Caldas, Anne-Lise Borresen-Dale, Hege G. Russnes, Ole Christian Lingjaerde
COMMUNICATIONS BIOLOGY
(2020)
Article
Genetics & Heredity
Zafar Iqbal, Jeanette Koht, Lasse Pihlstrom, Sandra P. Henriksen, Chiara Cappelletti, Michael Bjorn Russel, Osmar Norberto de Souza, Inger Marie Skogseid, Mathias Toft
NEUROLOGY-GENETICS
(2019)
