Review
Clinical Neurology
Yi Wu, Xue-bing Cao, Wei-qi Zeng, Heng Zhai, Xiao-qian Zhang, Xiao-man Yang, Chi Cheng, Jia-ling Wang, Xiao-mei Yang, Yan Xu
Summary: Transcranial magnetic stimulation is an effective non-invasive method for treating levodopa-induced dyskinesia, with beneficial effects and good patient tolerability. Changes in brain connectivity, neuroplasticity, and other factors play crucial roles in its efficacy, while new modes and targeting strategies may offer solutions for sustained efficacy in the future.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Shinya Nakamura, Yodai Kishimoto, Masaki Sekino, Motoaki Nakamura, Ken-Ichiro Tsutsui
Summary: Using low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) to inhibit neural activity in the ventral region of the medial frontal cortex (vMFC), this study found that the vMFC plays a causal role in regulating mood and the LF-rTMS-induced dysfunction of the vMFC serves as a valid nonhuman primate model of depression. The study also demonstrated that LF-rTMS targeting the vMFC induced depression-like symptoms in monkeys, including reduced movement activity, impaired sociability, decreased motivation, and increased plasma cortisol level.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Gong-Jun Ji, Tingting Liu, Ying Li, Pingping Liu, Jinmei Sun, Xingui Chen, Yanghua Tian, Xianwen Chen, Louisa Dahmani, Hesheng Liu, Kai Wang, Panpan Hu
Summary: Accelerated rTMS was found to significantly improve symptoms in patients with Parkinson's disease, with a swift and long-lasting treatment response. Imaging analyses revealed an increase in volume of the left globus pallidus (GP) after cTBS treatment, indicating a potential modulation of the motor circuitry involving the SMA-GP pathway for alleviating motor symptoms of PD.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Qianqian Si, Caiting Gan, Heng Zhang, Xingyue Cao, Huimin Sun, Min Wang, Lina Wang, Yongsheng Yuan, Kezhong Zhang
Summary: This study used dynamic functional network connectivity analysis to investigate the neural activity of levodopa-induced dyskinesia in Parkinson's disease. The results suggest that dyskinesia is associated with the dysfunctional inhibition of cognitive executive network on motor loops and excessive excitation of visual network and sensorimotor network.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Jean-Francois Daneault, Gloria Vergara-Diaz, Federico Parisi, Chen Admati, Christina Alfonso, Matilde Bertoli, Edoardo Bonizzoni, Gabriela Ferreira Carvalho, Gianluca Costante, Eric Eduardo Fabara, Naama Fixler, Fatemah Noushin Golabchi, John Growdon, Stefano Sapienza, Phil Snyder, Shahar Shpigelman, Lewis Sudarsky, Margaret Daeschler, Lauren Bataille, Solveig K. Sieberts, Larsson Omberg, Steven Moore, Paolo Bonato
Summary: Parkinson's disease is a neurodegenerative disorder with motor and non-motor symptoms. Current treatments focus on managing motor symptoms, but treatment side-effects may emerge. The Levodopa Response Study aimed to objectively quantify symptom severity in PD patients using wearable sensor data.
Article
Clinical Neurology
Daniele Belvisi, Andrea Fabbrini, Maria Ilenia De Bartolo, Matteo Costanzo, Nicoletta Manzo, Giovanni Fabbrini, Giovanni Defazio, Antonella Conte, Alfredo Berardelli
Summary: The study aimed to identify the pathophysiological substrate of Parkinson's disease subtypes using neurophysiological techniques. Two clinical clusters were identified, with one having milder symptoms and the other having a combination of severe motor and nonmotor manifestations. Differences in motor system dysfunction were observed between the subtypes, while sensory function and sensorimotor integration mechanisms did not differ.
MOVEMENT DISORDERS
(2021)
Article
Multidisciplinary Sciences
F. Konrad Schumacher, Lena V. Schumacher, Florian Amtage, Andreas Horn, Karl Egger, Tobias Piroth, Cornelius Weiller, Bjoern O. Schelter, Volker A. Coenen, Christoph P. Kaller
Summary: This study found that STN-DBS treatment of PD patients resulted in changes in the rostro-caudal hierarchical organization of the PFC, depending on the duration of the disease. Patients implanted early showed enhancement, while those implanted late showed attenuation of PFC hierarchical structure.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Emmanuelle Wilhelm, Caroline Quoilin, Gerard Derosiere, Susana Paco, Anne Jeanjean, Julie Duque
Summary: In Parkinson's disease, the lack of preparatory suppression in the primary motor cortex is associated with motor slowness and is related to disease duration and motor impairment. This finding suggests a potential marker for assessing motor preparation and impairment in Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Piniel Alphayo Kambey, Wen Ya Liu, Jiao Wu, Chuanxi Tang, Wokuheleza Buberwa, Adonira Saro, Alphonce M. K. Nyalali, Dianshuai Gao
Summary: This study revealed the crucial role of Amphiregulin (Areg) gene in levodopa-induced dyskinesia in Parkinson's disease. Inhibition of Areg was found to alleviate dyskinetic movements and decrease the expression of related proteins. Therefore, Areg may serve as a potential target for therapy development.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ritam Bandopadhyay, Nainshi Mishra, Ruhi Rana, Gagandeep Kaur, Mohammed M. Ghoneim, Sultan Alshehri, Gulam Mustafa, Javed Ahmad, Nabil. A. Alhakamy, Awanish Mishra
Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anatomy & Morphology
Brenton Hordacre, Mitchell R. Goldsworthy, Lynton Graetz, Michael C. Ridding
Summary: This research investigated the impact of baseline resting state functional connectivity on responses to continuous theta burst stimulation (cTBS). The results showed that a low beta frequency band model of connectivity played a crucial role in determining responses to spaced cTBS, suggesting that M1-frontocentral networks may have an important role in the effects of cTBS on corticospinal excitability.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Neurosciences
Javier Pena, Agurne Sampedro, Yolanda Balboa-Bandeira, Naroa Ibarretxe-Bilbao, Leire Zubiaurre-Elorza, M. Acebo Garcia-Guerrero, Natalia Ojeda
Summary: This study examines the neural basis of creativity and finds that the left DLPFC and left IFG are associated with divergent thinking and convergent thinking. The results show that tRNS may have advantages over tDCS in divergent thinking.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Tomasz Gutowski, Ryszard Antkiewicz, Stanislaw Szlufik
Summary: This paper presents a solution for creating personalized medicine intake schedules for Parkinson's disease patients. By using machine learning models and optimization algorithms, it can reduce treatment errors and the time required to establish medication schedules, with the potential to significantly improve treatment outcomes.
Article
Clinical Neurology
Huimin Sun, Caiting Gan, Lina Wang, Min Ji, Xingyue Cao, Yongsheng Yuan, Heng Zhang, Aidi Shan, Mengxi Gao, Kezhong Zhang
Summary: This study aimed to reveal the mechanisms of OFF-period FOG and levodopa-unresponsive FOG in PD. The study found that motor cortex disinhibition, represented by decreased SICI, is related to FOG in PD. Additionally, pharmacological treatment and high-frequency repetitive TMS can improve gait in FOG patients.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Shuolin Jiang, Cuijing Zhan, Peikun He, Shujun Feng, Yuyuan Gao, Jiehao Zhao, Limin Wang, Yuhu Zhang, Kun Nie, Yihui Qiu, Lijuan Wang
Summary: This study found that neuronavigated high-frequency rTMS at the left DLPFC is effective in improving depression, anxiety, and motor symptoms in Parkinson's disease patients.
Article
Clinical Neurology
Georgia Peakman, Lucy L. Russell, Rhian S. Convery, Jennifer M. Nicholas, John C. Van Swieten, Lize C. Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonca, Chris R. Butler, Alex Gerhard, Simon Ducharme, Isabelle Le Ber, Fabrizio Tagliavini, Isabel Santana, Florence Pasquier, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Jonathan D. Rohrer
Summary: The study compared the CDR+NACC FTLD and FRS in genetic forms of FTD, finding that both measures were correlated with disease severity in mutation carriers. However, discrepancies in disease staging were observed between the two scales and with clinician-judged symptomatic status. The study suggests that a new scale incorporating key symptoms in the FTD spectrum may be needed in future assessments.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Stefano Gazzina, Mario Grassi, Enrico Premi, Antonella Alberici, Alberto Benussi, Silvana Archetti, Roberto Gasparotti, Martina Bocchetta, David M. Cash, Emily G. Todd, Georgia Peakman, Rhian S. Convery, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Alexander Gerhard, Isabelle Le Ber, Florence Pasquier, Simon Ducharme, Johannes Levin, Adrian Danek, Sandro Sorbi, Markus Otto, Jonathan D. Rohrer, Barbara Borroni
Summary: This study investigated the relationship between GRN mutations and frontotemporal dementia and applied graph theory to analyze cortical thickness data. The results showed that global connectivity was significantly impaired in symptomatic GRN mutation carriers, while local connectivity exhibited perturbation only in carriers with symptoms.
NEUROBIOLOGY OF AGING
(2022)
Letter
Clinical Neurology
Francesco Misirocchi, Alessandro Zilioli, Alberto Benussi, Sabina Cappellari, Carlotta Mutti, Irene Florindo, Marco Spallazzi, Liborio Parrino
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
David J. Whiteside, Maura Malpetti, P. Simon Jones, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, John C. van Swieten, Harro Seelaar, Lize Jiskoot, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Isabelle Le Ber, Alexander Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Florence Pasquier, Arabella Bouzigues, Lucy L. Russell, Jonathan D. Rohrer, James B. Rowe, Timothy Rittman
Summary: This study investigated the role of changes in functional networks in predicting cognitive decline and conversion to symptomatic disease in familial frontotemporal dementia (FTD). The study found a characteristic pattern of dynamic network changes in FTD, which were correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was more prominent in those who later converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Giacomo Koch, Alessandro Martorana
Editorial Material
Neurosciences
Andrea Guerra, Gerd Tinkhauser, Alberto Benussi, Tommaso Bocci
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Susanna Lopez, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Alessandro Padovani, Flavio Nobili, Dario Arnaldi, Francesco Fama, Davide V. Moretti, Annachiara Cagnin, Giacomo Koch, Alberto Benussi, Marco Onofrj, Barbara Borroni, Andrea Soricelli, Raffaele Ferri, Carla Buttinelli, Franco Giubilei, Bahar Guntekin, Gorsev Yener, Fabrizio Stocchi, Laura Vacca, Laura Bonanni, Claudio Babiloni
Summary: This study compared the hubs of interdependencies in elderly individuals with and without Alzheimer's disease dementia (ADD) using rsEEG rhythms. The results showed that ADD patients have lower connectivity centrality and directionality compared to normal elderly individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Clinical Neurology
Steve Vucic, Kai-Hsiang Stanley Chen, Matthew C. Kiernan, Mark Hallett, David. H. Benninger, Vincenzo Di Lazzaro, Paolo M. Rossini, Alberto Benussi, Alfredo Berardelli, Antonio Curra, Sandro M. Krieg, Jean-Pascal Lefaucheur, Yew Long Lo, Richard A. Macdonell, Marcello Massimini, Mario Rosanova, Thomas Picht, Cathy M. Stinear, Walter Paulus, Yoshikazu Ugawa, Ulf Ziemann, Robert Chen
Summary: This review provides a comprehensive update on the clinical diagnostic utility of transcranial magnetic stimulation (TMS) in neurological diseases. TMS techniques have demonstrated clinical utility in various neurodegenerative, movement, episodic, chronic pain, and functional diseases. TMS measures can aid in the diagnosis of amyotrophic lateral sclerosis, stroke, myelopathy, and Alzheimer's disease, among others. Combining TMS with electroencephalography allows for the measurement of parameters altered in neurological disorders.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Valeria Bracca, Valentina Cantoni, Yasmine Gadola, Jasmine Rivolta, Maura Cosseddu, Rosanna Turrone, Salvatore Caratozzolo, Monica Di Luca, Alessandro Padovani, Barbara Borroni, Alberto Benussi
Summary: This study has investigated the neurophysiological correlates underlying altered time awareness in Alzheimer's disease (AD) and frontotemporal dementia (FTD) patients. The results revealed that AD patients often have difficulty in ordering past events, whereas FTD patients struggle with estimating temporal intervals between events. Impairments in glutamatergic and cholinergic circuits significantly predicted the likelihood of altered time awareness symptoms.
NEUROLOGICAL SCIENCES
(2023)
Review
Cell Biology
Alberto Benussi, Giorgi Batsikadze, Carina Franca, Rubens G. Cury, Roderick P. P. W. M. Maas
Summary: This paper comprehensively reviews the clinical and neurophysiological effects of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and dentate nucleus deep brain stimulation (DBS) in patients with hereditary ataxias, as well as the underlying mechanisms at the cellular and network level and future research perspectives.
Article
Nutrition & Dietetics
Valentina Bianco, Domenica Veniero, Alessia D'Acunto, Giacomo Koch, Silvia Picazio
Summary: Most people are tempted by high-calorie food, even if it goes against their long-term weight control goal. Inhibitory control plays a critical role in determining their food choices and weight outcomes. This study found that individuals with weaker inhibitory control consume more high-calorie food, while transcranial magnetic stimulation (TMS) can selectively disrupt this preference. These findings highlight the importance of inhibitory control in eating behavior and suggest potential implications for treating eating disorders.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Alberto Benussi, Barbara Borroni
Summary: This review article comprehensively explores the pathological features, diagnostic advancements, and therapeutic strategies of frontotemporal dementia (FTD). The authors discuss the potential of new diagnostic markers and disease-modifying treatments, as well as the exploration of neuromodulation techniques. The ongoing trials and multidisciplinary care reflect the continuous effort towards effective FTD treatments.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Martina Assogna, Enrico Premi, Stefano Gazzina, Alberto Benussi, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Roberto Gasparotti, Alessandro Padovani, Ehsan Tadayon, Sara Romanella, Giulia Sprugnoli, Alvaro Pascual-Leone, Francesco Di Lorenzo, Giacomo Koch, Barbara Borroni, Emiliano Santarnecchi
Summary: This observational study found that choroid plexus volume is significantly increased in patients with frontotemporal lobar degeneration (FTLD) spectrum, and it is associated with disease-specific biomarkers, cognitive/behavioral deficits, and patterns of cortical atrophy. Choroid plexus volume may serve as a potential biomarker for FTLD, especially at the early stage of the disease. Further longitudinal studies are needed to determine its role in disease onset and progression.
Article
Clinical Neurology
Alberto Benussi, Valentina Cantoni, Mario Grassi, Ilenia Libri, Maria Sofia Cotelli, Barbara Tarantino, Abhishek Datta, Chris Thomas, Nadine Huber, Sari Karkkainen, Sanna-Kaisa Herukka, Annakaisa Haapasalo, Massimiliano Filosto, Alessandro Padovani, Barbara Borroni
Summary: This study investigated the use of cortico-spinal transcranial direct current stimulation (tDCS) in ALS patients through a randomized, double-blind, sham-controlled trial followed by an open-label phase. The results showed that tDCS significantly improved global strength, caregiver burden, and quality of life scores in ALS patients, and these improvements were correlated with the restoration of intracortical connectivity measures. Additionally, the number of completed tDCS treatments influenced patient survival.
