Gut Feelings About α-Synuclein in Gastrointestinal Biopsies: Biomarker in the Making?

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Colonic mucosal  -synuclein lacks specificity as a biomarker for Parkinson disease

(2015) N. P. Visanji et al.   NEUROLOGY

Alpha-synuclein immunoreactivity patterns in the enteric nervous system

(2015) Iban Aldecoa et al.   NEUROSCIENCE LETTERS

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)

(2014) Maria Eugenia Herva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo gastric detection of α-synuclein inclusions in Parkinson's disease

(2014) Álvaro Sánchez-Ferro et al.   MOVEMENT DISORDERS

Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease

(2014) Daniela Berg et al.   MOVEMENT DISORDERS

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Submandibular Gland Biopsy for the Diagnosis of Parkinson Disease

(2013) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A study of calretinin in Hirschsprung pathology, particularly in total colonic aganglionosis

(2013) Melanie I. Morris et al.   JOURNAL OF PEDIATRIC SURGERY

Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

(2013) Alireza Roostaee et al.   Molecular Neurodegeneration

Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

(2013) Madison T. Gray et al.   MOVEMENT DISORDERS

Alimentary, my dear Watson? The challenges of enteric α-synuclein as a Parkinson's disease biomarker

(2013) Naomi P. Visanji et al.   MOVEMENT DISORDERS

Enteric alpha-synuclein expression is increased in Parkinson's disease but not Alzheimer's disease

(2013) Andrea Gold et al.   MOVEMENT DISORDERS

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Alpha-synuclein expression patterns in the colonic submucosal plexus of the aging Fischer 344 rat: implications for biopsies in aging and neurodegenerative disorders?

(2013) R. J. Phillips et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Parkinson’s disease is not associated with gastrointestinal myenteric ganglion neuron loss

(2012) Dana M. Annerino et al.   ACTA NEUROPATHOLOGICA

Spinal cord lesions in sporadic Parkinson’s disease

(2012) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease

(2012) Lynne I. McGuire et al.   ANNALS OF NEUROLOGY

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

(2012) Nunilo Cremades et al.   CELL

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

(2012) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

(2012) Martina Böttner et al.   NEUROBIOLOGY OF DISEASE

Analysis of colonic alpha-synuclein pathology in multiple system atrophy

(2012) Hélène Pouclet et al.   PARKINSONISM & RELATED DISORDERS

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

Pale Neurites, Premature α-Synuclein Aggregates with Centripetal Extension from Axon Collaterals

(2011) Toshiro Kanazawa et al.   BRAIN PATHOLOGY

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease

(2011) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion

(2011) Ryuichiro Atarashi et al.   NATURE MEDICINE

A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

(2011) Hélène Pouclet et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

α-synuclein phosphorylation and truncation are normal events in the adult human brain

(2011) G. Muntané et al.   NEUROSCIENCE

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

The brain to gut pathway: a possible route of prion transmission

(2010) Victoria A Lawson et al.   GUT

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms

(2010) Thibaud Lebouvier et al.   PLoS One

Assessment of α-Synuclein Pathology: A Study of the BrainNet Europe Consortium

(2009) Irina Alafuzoff et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Incidental Lewy body disease restricted to the heart and stellate ganglia

(2009) Yasuo Miki et al.   MOVEMENT DISORDERS

Can we image premotor Parkinson disease?

(2009) K. Marek et al.   NEUROLOGY

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of α-synuclein immunohistochemical methods used by invited experts

(2008) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Pathological lesions in colonic biopsies during Parkinson's disease

(2008) T Lebouvier et al.   GUT