Reproductive toxicity following in utero and lactational exposure to a human-relevant phthalate mixture in rats

Impact of Fetal Exposure to Endocrine Disrupting Chemical Mixtures on FOXA3 Gene and Protein Expression in Adult Rat Testes

(2023) Casandra Walker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exposure to phthalates and female reproductive health: A literature review

(2022) Carla Giovana Basso et al.   REPRODUCTIVE TOXICOLOGY

Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys

(2022) Jane S. Burns et al.   ENVIRONMENTAL RESEARCH

Association of prenatal phthalate exposure with pubertal development in Spanish boys and girls

(2022) Carmen Freire et al.   ENVIRONMENTAL RESEARCH

In utero exposure to phthalates and reproductive toxicity in rodents

(2021) Anastasia Repouskou et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Maternal Exposure to Dibutyl Phthalate (DBP) or Diethylstilbestrol (DES) Leads to Long-Term Changes in Hypothalamic Gene Expression and Sexual Behavior

(2021) Damien Hunter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach that Defines a Unique Adverse Outcome Pathway

(2021) L Earl Gray et al.   TOXICOLOGICAL SCIENCES

A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat

(2021) Justin M. Conley et al.   ENVIRONMENT INTERNATIONAL

Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR’s toxicological profile database

(2020) MC Buser et al.   INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH

In utero exposure to low doses of genistein and di‐(2‐ethylhexyl) phthalate (DEHP) alters innate immune cells in neonatal and adult rat testes

(2020) Casandra Walker et al.   Andrology

The Neonatal and Adult Human Testis Defined at the Single-Cell Level

(2019) Abhishek Sohni et al.   Cell Reports

Gestational exposure to an epidemiologically defined mixture of phthalates leads to gonadal dysfunction in mouse offspring of both sexes

(2019) Anastasia Repouskou et al.   Scientific Reports

In utero and lactational exposure to diisopentyl phthalate (DiPeP) induces fetal toxicity and antiandrogenic effects in rats

(2019) Tatiana Zauer Curi et al.   TOXICOLOGICAL SCIENCES

Unexpected, ubiquitous exposure of pregnant Brazilian women to diisopentyl phthalate, one of the most potent antiandrogenic phthalates

(2018) Michele Bertoncello Souza et al.   ENVIRONMENT INTERNATIONAL

Mixed “Antiandrogenic” Chemicals at Low Individual Doses Produce Reproductive Tract Malformations in the Male Rat

(2018) Justin M Conley et al.   TOXICOLOGICAL SCIENCES

Validation of an automated counting procedure for phthalate-induced testicular multinucleated germ cells

(2018) Daniel J. Spade et al.   TOXICOLOGY LETTERS

Assessment of the analgesic dipyrone as a possible (anti)androgenic endocrine disruptor

(2018) Marcella Tapias Passoni et al.   TOXICOLOGY LETTERS

All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity

(2018) Daniel J Spade et al.   TOXICOLOGICAL SCIENCES

Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment

(2017) Kembra L. Howdeshell et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Urinary concentrations of 25 phthalate metabolites in Brazilian children and their association with oxidative DNA damage

(2017) Bruno A. Rocha et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

(2017) Changqing Zhou et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Disruption of Retinol (Vitamin A) Signaling by Phthalate Esters: SAR and Mechanism Studies

(2016) Yanling Chen et al.   PLoS One

Di-n-Butyl Phthalate Induces Multinucleated Germ Cells in the Rat Fetal Testis Through a Nonproliferative Mechanism1

(2015) Daniel J. Spade et al.   BIOLOGY OF REPRODUCTION

Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells1

(2015) Mickaël Di-Luoffo et al.   BIOLOGY OF REPRODUCTION

Establishing the “Biological Relevance” of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels

(2015) Leon Earl Gray et al.   TOXICOLOGICAL SCIENCES

A Short-term In Vivo Screen Using Fetal Testosterone Production, a Key Event in the Phthalate Adverse Outcome Pathway, to Predict Disruption of Sexual Differentiation

(2014) Johnathan R. Furr et al.   TOXICOLOGICAL SCIENCES

In Uteroand Lactational Exposure to Fluoxetine in Wistar Rats: Pregnancy Outcomes and Sexual Development

(2013) Juliane C. Müller et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Urinary Phthalates From 168 Girls and Boys Measured Twice a Year During a 5-Year Period: Associations With Adrenal Androgen Levels and Puberty

(2013) A. Mouritsen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Multinucleated cells are involved in normal development and apoptosis in mouse testes

(2013) LAN LUO et al.   Molecular Medicine Reports

Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

(2013) Marta Axelstad et al.   REPRODUCTION

In utero phthalate effects in the female rat: A model for MRKH syndrome

(2013) Bethany R. Hannas et al.   TOXICOLOGY LETTERS

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

(2012) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Human Fetal Testis Xenografts Are Resistant to Phthalate-Induced Endocrine Disruption

(2012) Nicholas E Heger et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects of perinatal exposure to bisphenol A and di(2-ethylhexyl)-phthalate on gonadal development of male mice

(2012) Wei Xi et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Mixtures of endocrine disrupting contaminants modelled on human high end exposures: an exploratory study in rats

(2012) S. Christiansen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Induction and Persistence of Abnormal Testicular Germ Cells Following Gestational Exposure to Di-(n-Butyl) Phthalate in p53-Null Mice

(2012) C. M. Saffarini et al.   JOURNAL OF ANDROLOGY

Initiating Meiosis: The Case for Retinoic Acid1

(2011) Michael D. Griswold et al.   BIOLOGY OF REPRODUCTION

Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability

(2011) M. S. Jobling et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Dose-Response Assessment of Fetal Testosterone Production and Gene Expression Levels in Rat Testes Following InUtero Exposure to Diethylhexyl Phthalate, Diisobutyl Phthalate, Diisoheptyl Phthalate, and Diisononyl Phthalate

(2011) Bethany R. Hannas et al.   TOXICOLOGICAL SCIENCES

The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker

(2010) D. Rebourcet et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity

(2010) C. V. Rider et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Dipentyl Phthalate Dosing during Sexual Differentiation Disrupts Fetal Testis Function and Postnatal Development of the Male Sprague-Dawley Rat with Greater Relative Potency than Other Phthalates

(2010) Bethany R. Hannas et al.   TOXICOLOGICAL SCIENCES

Androgen action in the masculinization programming window and development of male reproductive organs

(2009) D. J. MacLeod et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Reproductive toxicity of phthalate esters

(2009) Anderson Joel Martino-Andrade et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development

(2009) Cynthia V. Rider et al.   TOXICOLOGIC PATHOLOGY

Transgenerational Effects of Di (2-Ethylhexyl) Phthalate in the Male CRL:CD(SD) Rat: Added Value of Assessing Multiple Offspring per Litter

(2009) Leon Earl Gray et al.   TOXICOLOGICAL SCIENCES

In Utero Exposure to Di-(2-ethylhexyl) Phthalate Exerts Both Short-Term and Long-Lasting Suppressive Effects on Testosterone Production in the Rat1

(2008) Martine Culty et al.   BIOLOGY OF REPRODUCTION

Antagonistic Effects of Testosterone and the Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate onINSL3Transcription in Leydig Cells

(2008) Éric Laguë et al.   ENDOCRINOLOGY

Coadministration of active phthalates results in disruption of foetal testicular function in rats

(2008) Anderson J. Martino-Andrade et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism

(2008) Michelle Welsh et al.   JOURNAL OF CLINICAL INVESTIGATION

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

(2008) Kembra L. Howdeshell et al.   TOXICOLOGICAL SCIENCES

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL