Article
Dermatology
Mufqi Handaru Priyanto, Lili Legiawati, Siti Rizny F. Saldi, Em Yunir, Eliza Miranda
Summary: This study aimed to compare the vitamin D levels in diabetic patients with and without diabetic foot ulcers (DFU), and assess the duration and severity of DFU in relation to vitamin D levels. The results showed that the vitamin D levels were lower in patients with DFU compared to those without DFU. However, there was insufficient evidence to conclude a correlation between the duration and severity of DFU and vitamin D levels based on the PEDIS score.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Endocrinology & Metabolism
Alana C. Keegan, Sanuja Bose, Katherine M. McDermott, Midori P. Starks White, David P. Stonko, Danielle Jeddah, Eilat Lev-Ari, Joanna Rutkowski, Ronald Sherman, Christopher J. Abularrage, Elizabeth Selvin, Caitlin W. Hicks
Summary: This study assessed the feasibility of a remote wound monitoring system (Healthy.io Minuteful for Wound Digital Management System) for lower extremity wounds. The results showed that the system is feasible for use by patients and/or their caregivers, providing accurate and effective wound monitoring.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
Jiezhi Dai, Yu Zhou, Shasha Mei, Hua Chen
Summary: This retrospective study investigated the effect of antibiotic bone cement on patients with infected diabetic foot ulcer (DFU). The results showed that compared with the control group, the PMMA group had a higher complete wound healing rate, fewer frequencies of debridement procedures, and a shorter healing duration. The application of antibiotic bone cement is an effective solution for infected DFU treatment.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhou, Tianhong Wei, Zhiyou He
Summary: The study demonstrated that ADSCs accelerate LEC proliferation, migration, and lymphangiogenesis through the METTL3 pathway and regulate VEGF-C expression via the METTL3/IGF2BP2-m6A pathway in DFU mice. These findings suggest that ADSCs may enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to promote wound healing in DFUs.
MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
V. Sathya Preiya, V. D. Ambeth Kumar
Summary: The World Health Organization (WHO) has identified diabetes mellitus (DM) as a prevalent disease worldwide. Foot ulcers are a significant complication associated with DM, and it is crucial to prioritize their treatment to prevent amputation. This study introduces a methodology for analyzing foot ulcer images in diabetic patients using deep learning techniques to provide early and effective treatment.
Article
Endocrinology & Metabolism
Mingyang Jiang, Fu Gan, Meishe Gan, Huachu Deng, Xuxu Chen, Xintao Yuan, Danyi Huang, Siyi Liu, Baoyu Qin, Yanhong Wei, Shanggui Su, Zhandong Bo
Summary: This study identified 12 risk factors associated with diabetic foot ulcer in patients with type 2 diabetes mellitus and established a reliable prediction model.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Pharmacology & Pharmacy
Michael G. Monaghan, Rajiv Borah, Charlotte Thomsen, Shane Browne
Summary: Diabetic foot ulcers (DFUs) are a severe complication that can lead to limb amputation. The presence of unresolved inflammation in the DFU microenvironment is a key factor contributing to the non-healing nature of DFUs. Therefore, controlling and modulating the inflammatory response is crucial for the treatment of DFUs.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Infectious Diseases
Xi Yang, Ting Yan, Danfeng Shen, Mengyao Sheng, Wenya Huang, Li Li, Dayang Chai
Summary: This study investigated factors associated with the healing of infected foot ulcers in patients with type 2 diabetes after antimicrobial therapy. Wagner grade, essential hypertension, platelet count, Gram negative bacteria, and neutrophil-to-lymphocyte ratio were found to be predictive of wound healing outcomes. Furthermore, a linear relationship between platelet levels and wound healing outcomes was observed, with lower platelet levels indicating a worse healing outcome.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biology
Yanling Wang, Yinzhen Pi, Li Hu, Zhihong Peng, Hanyang Hu, Jinjin Zhao, Yun Zhou, Dongbo Wang
Summary: Foot ulcers are a common complication of diabetes mellitus and associated with high morbidity and mortality. This study aimed to investigate novel wound healing pathways in diabetic foot ulcers using proteomics and network pharmacology analysis. Proteomics analysis revealed differentially expressed proteins in wound tissues from healthy controls and diabetic foot ulcers, and further pathway analysis identified potential pathways associated with diabetic foot ulcers. The study confirmed protein alterations in the wound healing process and provided insights into the molecular mechanisms driving diabetic foot ulcers.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Analytical
Bernd Ploderer, Damien Clark, Ross Brown, Joel Harman, Peter A. Lazzarini, Jaap J. Van Netten
Summary: People with DFUs need to consistently perform self-care to promote healing, but it can be difficult to detect improvements. To address this, a mobile app called MyFootCare was developed to self-monitor DFU healing progression. The study evaluates the engagement and perceived value of MyFootCare over 3 months for people with plantar DFUs. Results showed that most participants found MyFootCare valuable for monitoring progress and reflecting on self-care events, but engagement varied due to facilitators and barriers. Further improvements and clinical outcome testing are needed.
Article
Microbiology
Maria Stankowska, Katarzyna Garbacz, Anna Korzon-Burakowska, Marek Bronk, Monika Skotarczak, Anna Szymanska-Dubowik
Summary: This study assessed the factors influencing the infection of diabetic foot ulcers by methicillin-resistant S. aureus (MRSA) and found that MRSA infection is associated with a higher incidence of osteitis. MRSA infection is more common in men and patients with type 2 diabetes, and is often associated with the presence of Pseudomonas sp. and other non-fermenting bacilli.
Review
Chemistry, Analytical
Arturas Kairys, Renata Pauliukiene, Vidas Raudonis, Jonas Ceponis
Summary: It is estimated that 1 in 10 adults worldwide have diabetes, and diabetic foot ulcers are common complications that can lead to lower-limb amputation and reduced life expectancy. Recent research has shown that computer vision can be used for non-contact detection and segmentation of foot ulcers. However, there are limitations in terms of lighting conditions and dataset annotation. This paper reviews the use of artificial intelligence for ulcer detection and segmentation, and suggests the need for further research on image preprocessing and augmentation methods.
Article
Endocrinology & Metabolism
M. Graca Pereira, Margarida Vilaca, Susana Pedras, Andre Carvalho, Kavita Vedhara, M. Jesus Dantas, Luis Machado
Summary: This study aimed to identify the demographic, clinical, and psychological factors influencing the healing of diabetic foot ulcers (DFU) and the favorable healing process. The results showed that illness perceptions were the only predictor of wound healing, while being female, with adequate health literacy, and a first-time DFU predicted a favorable healing process. Brief and comprehensive interventions should be implemented to change misperceptions and promote DFU literacy for better treatment outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Marco Meloni, Daniele Morosetti, Laura Giurato, Matteo Stefanini, Giorgio Loreni, Marco Doddi, Andrea Panunzi, Alfonso Bellia, Roberto Gandini, Enrico Brocco, Jose Luis Lazaro-Martinez, Davide Lauro, Luigi Uccioli
Summary: This study evaluated the effectiveness of foot revascularization in individuals with diabetic foot ulcers and below-the-ankle arterial disease, finding that foot revascularization is essential for healing and preventing major amputations in DFU patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nursing
Ma'en Zaid Abu-Qamar, Vivien Kemp, Lisa Whitehead
Summary: The study identified that the main origins of external foot trauma among people with diabetes were puncture wounds, ill-fitting footwear, and self-care practices. Most ulcers occurred in the home environment and were preventable in nature. Assessment of an individual's local context and actions to reduce risk are important priorities.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)