Article
Medicine, General & Internal
Ju-Hee Lee, Jae-Hyeong Park, In-Chang Hwang, Jin Joo Park, Jun-Bean Park
Summary: Pulmonary hypertension associated with left heart disease is the most common form of pulmonary hypertension, which has a significant impact on patients' health. The prevalence of persistent PH-LHD in patients observed on follow-up echocardiography was 21.6% and was associated with decreased left atrial function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Zied Ltaief, Patrick Yerly, Lucas Liaudet
Summary: Pulmonary hypertension (PH) associated with left heart diseases (PH-LHD), or group 2 PH, is the most common form of PH. It is caused by the transmission of high left heart pressures to the right ventricle, which increases the workload on the right ventricle by reducing pulmonary artery compliance. In some patients, remodeling of the pulmonary circulation leads to a pre-capillary PH phenotype, with elevated pulmonary vascular resistance further increasing the right ventricle's workload. Current targeted therapies have shown limited effectiveness in PH-LHD patients compared to other forms of pre-capillary PH, and further research is needed to determine their potential benefits in specific patient subgroups with different hemodynamic phenotypes and degrees of right ventricle dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)
Article
Veterinary Sciences
Carlotta Valente, Massimiliano Tursi, Helen Poser, Carlo Guglielmini
Summary: A five-month-old European shorthair female kitten was referred due to recurrent respiratory distress and was diagnosed with severe precapillary pulmonary hypertension and interstitial pneumonia associated with right-sided cardiac remodeling. The cat quickly died from respiratory insufficiency. Pathological findings revealed left pulmonary artery coarctation, severe right-sided cardiac hypertrophy, and bilateral pneumonia, making this the first reported case of pulmonary artery coarctation associated with pneumonia and PH in a cat.
VETERINARY SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Gong, Xinli Guo, Ke Wan, Chen Chen, Xiaoling Chen, Jiajun Guo, Juan He, Lidan Yin, Bi Wen, Shoufang Pu, Yucheng Chen
Summary: This study investigated the diagnostic value of MRI-derived corrected pulmonary transit time (PTTc) in patients with pulmonary hypertension due to left heart disease. The results showed that PTTc was significantly prolonged in patients with combined precapillary and postcapillary pulmonary hypertension, compared to patients with isolated postcapillary pulmonary hypertension and healthy subjects. Prolonged PTTc was associated with increased pulmonary vascular resistance and could be used as an independent predictor of combined precapillary and postcapillary pulmonary hypertension.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Medicine, General & Internal
Matteo Toma, Roberta Miceli, Edoardo Bonsante, Davide Colombo, Marco Confalonieri, Andrea Garascia, Stefano Ghio, Mariangela Lattanzio, Carlo Maria Lombardi, Giuseppe Paciocco, Cristina Piccinino, Irene Rota, Caterina Santolamazza, Laura Scelsi, Piermario Scuri, Davide Stolfo, Antonella Vincenzi, Lorenzo Volpiano, Marco Vicenzi, Pietro Ameri
Summary: The study found that pulmonary arterial hypertension (PAH) in the elderly is often associated with left heart disease (LHD), but is still treated as PAH. LHD patients typically have higher pulmonary artery wedge pressure and lower pulmonary vascular resistance due to the prevalent presence of diabetes and chronic kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Susanne J. Maurer, Veronika Habdank, Juergen Horer, Peter Ewert, Oktay Tutarel
Summary: This study aimed to investigate the risk factors for poor outcome in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD). The results showed that NT-proBNP is an independent predictor of all-cause mortality in PAH-CHD patients. The role of CRP and uric acid should be further studied.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Ting Wang, Yue Xing, Bingming Peng, Kai Yang, Chenting Zhang, Yuqin Chen, Gang Geng, Qubei Li, Jian Fu, Mi Li, Zhengxiu Luo, Zhou Fu, Jian Wang
Summary: This study systematically defines and compares the upper respiratory tract microbiota in pediatric PH patients, CHD and reference subjects, as well as the differences between pediatric and adult PH patients.
Article
Respiratory System
Yogesh N. Reddy, Barry A. Borlaug
Summary: The objective criteria for defining pulmonary hypertension in left heart disease vary, but generally refer to a higher pulmonary artery pressure in comparison to left atrial pressure. Treatment options for PH in left heart disease primarily focus on treating the left heart component, with some therapies targeting the pulmonary vasculature.
CLINICS IN CHEST MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gingy Ronen Balmor, Michael J. Segel, Paul Fefer, Elad Maor, Sagit Ben-Zekrey, Amit Segev
Summary: In patients suspected of having PHTN, ventricular septal motion abnormalities are strongly associated with pre-capillary PHTN, indicating that these patients should undergo further evaluation with right heart catheterization.
HEART LUNG AND CIRCULATION
(2022)
Review
Cardiac & Cardiovascular Systems
Maolin Zhao, Jian Liu, Mei Xin, Ke Yang, Honghao Huang, Wenxin Zhang, Jinbao Zhang, Siyi He
Summary: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a progressive condition with uncertain physiological course. Omics technology, such as genomics, transcriptomics, epigenomics, proteomics, metabolomics, and multi-omics integration, has provided advanced techniques for comprehensive assessment of the disease and identification of treatment strategies. Recent research has made significant progress in understanding PAH-CHD through the application of omics approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Qian Zhang, Fang Zhu, Guocheng Shi, Chen Hu, Weituo Zhang, Puzhen Huang, Chunfeng Zhu, Hong Gu, Dong Yang, Qiangqiang Li, Yonghua Niu, Hao Chen, Ruixiang Ma, Ziyi Pan, Huixian Miao, Xin Zhang, Genxia Li, Yabing Tang, Guyuan Qiao, Yichen Yan, Zhongqun Zhu, Hao Zhang, Fengzhen Han, Yanna Li, Jianhua Lin, Huiwen Chen
Summary: This study evaluated the pregnancy outcomes in women with congenital heart disease (CHD) with and without pulmonary hypertension (PH). The results showed that women with CHD-associated mild PH had better pregnancy outcomes compared to those with moderate-to-severe PH, with similar outcomes to women with CHD and no PH.
Article
Pediatrics
Reem Gaheen, Doaa El Amrousy, Hossam Hodeib, Shimaa Elnemr
Summary: The study found that plasma copeptin levels are elevated in children with PAH-CHD and can serve as a good predictive marker for the severity of PAH and poor prognosis in these children. Plasma copeptin levels are positively correlated with mean pulmonary pressure, pulmonary vascular resistance, and pulmonary blood flow, while negatively correlated with right ventricular diastolic function.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Cardiac & Cardiovascular Systems
Felicity Lee, Lisa M. Mielniczuk
Summary: Pulmonary hypertension due to left heart disease is a common complication of heart failure, with significant changes in classification and treatment after the Sixth World Symposium on Pulmonary Hypertension in 2018. Categorization into isolated postcapillary PH and combined precapillary and postcapillary PH is important, as the latter is associated with worse outcomes similar to pulmonary arterial hypertension. Despite limited benefits from medical therapy for pulmonary arterial hypertension, expert centres in Canada offer ongoing care for complex patient subgroups with PH-LHD.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Amalia Baroutidou, Alexandra Arvanitaki, Adam Hatzidakis, Georgia Pitsiou, Antonios Ziakas, Haralambos Karvounis, George Giannakoulas
Summary: Haemoptysis is a severe bleeding manifestation in the clinical course of pulmonary arterial hypertension associated with congenital heart disease. Dysfunction of the pulmonary vascular bed increases the risk of haemoptysis episodes, and despite treatment strategies like BAE, bleeding recurrences are prevalent. There is currently no clear guideline regarding the use of oral anticoagulation in patients with haemoptysis.
JOURNAL OF CLINICAL MEDICINE
(2022)