Review
Critical Care Medicine
Marion Delcroix, Catharina Belge, Geert Maleux, Laurent Godinas
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism. The treatment options for inoperable patients with CTEPH include medical therapy, anticoagulation, and balloon pulmonary angioplasty (BPA). This paper emphasizes the importance of a multidisciplinary approach in managing inoperable CTEPH patients.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Plant Sciences
Adriana Ribeiro, Rita Serrano, Isabel B. Moreira da Silva, Elsa T. Gomes, Joao F. Pinto, Olga Silva
Summary: This study aims to establish quality criteria for Diospyros villosa root to ensure its sustainable and safe use in pharmaceutical preparations. The root samples have specific microscopic characteristics and contain polyphenolic compounds as the main constituents. The particle size of the powder is suitable for use as a fine powder.
Article
Respiratory System
Abdullah M. Aldalaan, Sarfraz A. Saleemi, Ihab Weheba, Abeer Abdelsayed, Maha M. Aleid, Fatima Alzubi, Hamdeia Zaytoun, Nadeen Alharbi
Summary: The study presented the initial results of the 'SAUDIPH' registry, focusing on assessing patient characteristics, treatment approach, and clinical outcomes in PAH patients. The most common etiology was Group 1 PH, with improvements in functional class and NT-proBNP observed in most patients. The estimated 1-year survival rate was better than previous studies, possibly due to the wider use of combination therapy and the high prevalence of CHD-PAH.
Article
Cardiac & Cardiovascular Systems
Justin C. Y. Chan, H. S. Jeffrey Man, Usman M. Asghar, Karen Mcrae, Yidan Zhao, Laura L. Donahoe, Licun Wu, John Granton, Marc de Perrot
Summary: This study aimed to investigate the impact of sex on patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary endarterectomy. The results showed that female patients had a greater need for targeted PH medical therapy postoperatively, emphasizing the importance of early reassessment and long-term follow-up.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Review
Pharmacology & Pharmacy
Ruihua Zhang, Tengfei Li, Yueming Shao, Wei Bai, Xiaoyu Wen
Summary: This study systematically reviewed and meta-analyzed the therapeutic effect of PAH agents on POPH. The results showed that PAH agents can improve cardiopulmonary hemodynamics and cardiac function in patients with POPH, especially in patients with moderate to severe POPH.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Critical Care Medicine
Shelsey Johnson, Natascha Sommer, Katherine Cox-Flaherty, Norbert Weissmann, Corey E. Ventetuolo, Bradley A. Maron
Summary: This article summarizes the major advances in pulmonary arterial hypertension, pulmonary hypertension associated with lung disease, and chronic thromboembolic PH. It highlights key findings in basic, translational, and clinical research, and discusses the latest progress in translational pulmonary vascular biology and the management of PH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Nicholas A. Kolaitis
Summary: Lung transplantation is a unique and effective treatment option for patients with end-stage pulmonary arterial hypertension. However, these patients face various challenges and inequities in the organ allocation process, resulting in less favorable long-term outcomes.
Article
Medicine, General & Internal
Panagiotis Karyofyllis, Eftychia Demerouti, George Giannakoulas, Anastasia Anthi, Alexandra Arvanitaki, George Athanassopoulos, Christos Feloukidis, Ioannis Iakovou, Theodora Kostelidou, Ioanna Mitrouska, Sophia-Anastasia Mouratoglou, Stylianos E. Orfanos, Christos Pappas, Georgia Pitsiou, Eleftheria-Garyfallia Tsetika, Dimitrios Tsiapras, Vassilios Voudris, Athanassios Manginas
Summary: This study analyzed data from 180 BPA procedures in CTEPH patients and found that the procedure significantly improved mean pulmonary arterial pressure, pulmonary vascular resistance, and NT-proBNP levels, with a modest improvement in cardiac index. Although there were some complications associated with BPA, the overall survival rate was high, indicating that BPA is a promising therapeutic option for CTEPH patients in Greece.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Rubin Tan, Qiang You, Dongdong Yu, Chushu Xiao, Joseph Adu-Amankwaah, Jie Cui, Ting Zhang
Summary: In this study, we identified novel common hub genes involved in pulmonary artery remodeling in different PH groups through the analysis of gene expression data. We verified the top 10 candidate genes through animal model validation. This study provides new target genes for further research on the mechanisms and treatment of PH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Simon R. Schneider, Laura C. Mayer, Mona Lichtblau, Charlotte Berlier, Esther I. Schwarz, Stephanie Saxer, Michael Furian, Konrad E. Bloch, Silvia Ulrich
Summary: In patients with pulmonary hypertension, exposure to hypoxia led to a shorter constant work-rate exercise test time compared to normoxia, accompanied by hypoxemia, lactacidemia, and hypocapnia. However, pulmonary hemodynamics and dyspnea remained unchanged, indicating that the exercise limitation induced by hypoxia may be due to reduced oxygen delivery causing peripheral tissue hypoxia, increased lactic acid production, and hyperventilation.
Review
Medicine, General & Internal
Charles D. Burger, Hilary M. DuBrock, Rodrigo Cartin-Ceba, John E. Moss, Brian P. Shapiro, Robert P. Frantz
Summary: Pulmonary hypertension is a common manifestation of severe cardiopulmonary disease, while pulmonary arterial hypertension is more prevalent in young women. A multidisciplinary approach is recommended for evaluating and treating patients. Recent publications have provided new information on the evaluation and management of pulmonary hypertension.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Medicine, General & Internal
Nicolas Maneiro M. Melon, Maite Velazquez Martin, Sergio Huertas Nieto, Agustin Albarran Gonzalez-Trevilla, Fernando Sarnago Cebada, Alejandro Cruz Utrilla, Williams Hinojosa Camargo, Ricardo Aguilar Colindres, Maria Melendo Viu, Maria Jesus Lopez Gude, Rafael Morales Ruiz, Marta Perez Nunez, Fernando Arribas Ynsaurriaga, Pilar Escribano Subias
Summary: This study retrospectively collected data from 14 patients with persistent pulmonary hypertension (PH) after pulmonary endarterectomy (PEA) who were treated with balloon pulmonary angioplasty (BPA). The results showed that BPA effectively reduced pulmonary arterial pressure and pulmonary vascular resistance, and improved the clinical status of patients. Severe BPA-related complications were rare and no perioperative deaths were observed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Critical Care Medicine
Gabor Kovacs, Alexander Avian, Gerhard Bachmaier, Natascha Troester, Adrienn Tornyos, Philipp Douschan, Vasile Foris, Teresa Sassmann, Katarina Zeder, Joerg Lindenmann, Luka Brcic, Michael Fuchsjaeger, Alvar Agusti, Horst Olschewski
Summary: By combining echocardiography, NT-proBNP level, and PA to Ao diameter ratio, severe PH in patients with COPD can be predicted with high sensitivity and specificity. The contribution of severe airflow limitation and severe PH to impaired survival is comparable.
Article
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos
Summary: Pulmonary artery denervation is a novel intervention aimed at reducing sympathetic activity in the pulmonary circulation for the treatment of pulmonary arterial hypertension. Despite some positive effects shown in pre-clinical studies and initial clinical trials, the technique's scope in current practice remains limited due to the lack of well-designed, large-scale, international randomized controlled clinical trials.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
