Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology

A predictive model of non-cardia gastric adenocarcinoma risk using antibody response to Helicobacter pylori proteins and pepsinogen

(2022) John D Murphy et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Machine learning-based personalised prediction of gastric cancer incidence using the endoscopic and histological findings at the initial endoscopy

(2022) Junya Arai et al.   GASTROINTESTINAL ENDOSCOPY

Deep Learning based on hematoxylin‐eosin staining outperforms immunohistochemistry in predicting molecular subtypes of gastric adenocarcinoma

(2022) Nadine Flinner et al.   JOURNAL OF PATHOLOGY

An artificial intelligence method to assess the tumor microenvironment with treatment outcomes for gastric cancer patients after gastrectomy

(2022) Tao Chen et al.   Journal of Translational Medicine

Interpretable tumor differentiation grade and microsatellite instability recognition in gastric cancer using deep learning

(2022) Feng Su et al.   LABORATORY INVESTIGATION

Nivolumab plus chemotherapy versus placebo plus chemotherapy in patients with HER2-negative, untreated, unresectable advanced or recurrent gastric or gastro-oesophageal junction cancer (ATTRACTION-4): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial

(2022) Yoon-Koo Kang et al.   LANCET ONCOLOGY

Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer

(2022) Souvick Roy et al.   Molecular Cancer

Preoperative prediction for lymph node metastasis in early gastric cancer by interpretable machine learning models: A multicenter study

(2022) Haixing Zhu et al.   SURGERY

Development and validation of a prognostic and predictive 32-gene signature for gastric cancer

(2022) Jae-Ho Cheong et al.   Nature Communications

Machine learning analysis for the noninvasive prediction of lymphovascular invasion in gastric cancer using PET/CT and enhanced CT-based radiomics and clinical variables

(2022) Lijing Fan et al.   Abdominal Radiology

Construction and Multicenter Diagnostic Verification of Intelligent Recognition System for Endoscopic Images From Early Gastric Cancer Based on YOLO-V3 Algorithm

(2022) Zhendong Yao et al.   Frontiers in Oncology

Characterization of PANoptosis patterns predicts survival and immunotherapy response in gastric cancer

(2022) Hongda Pan et al.   CLINICAL IMMUNOLOGY

StoHisNet: A hybrid multi-classification model with CNN and Transformer for gastric pathology images

(2022) Bangkang Fu et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

GasHisSDB: A new gastric histopathology image dataset for computer aided diagnosis of gastric cancer

(2022) Weiming Hu et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Effect of Helicobacter pylori Eradication on Gastric Cancer Prevention: Updated Report From a Randomized Controlled Trial With 26.5 Years of Follow-up

(2022) Lingjun Yan et al.   GASTROENTEROLOGY

Insights into cell classification based on combination of multiple cellular mechanical phenotypes by using machine learning algorithm

(2022) Yanling Tian et al.   Journal of the Mechanical Behavior of Biomedical Materials

The future of early cancer detection

(2022) Rebecca C. Fitzgerald et al.   NATURE MEDICINE

CT-based radiomics analysis in the prediction of response to neoadjuvant chemotherapy in locally advanced gastric cancer: A dual-center study

(2022) Ruirui Song et al.   RADIOTHERAPY AND ONCOLOGY

Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC

(2022) Xing Niu et al.   SEMINARS IN CANCER BIOLOGY

Long Non-Coding RNA and RNA-Binding Protein Interactions in Cancer: Experimental and Machine Learning Approaches

(2022) Hibah Shaath et al.   SEMINARS IN CANCER BIOLOGY

Clinical outcome of the delineation-without-negative-biopsy strategy in magnifying image-enhanced endoscopy for identifying the extent of differentiated-type early gastric cancer

(2022) Yoshiyasu Kitagawa et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

A novel flexible auxiliary single-arm transluminal endoscopic robot facilitates endoscopic submucosal dissection of gastric lesions (with video)

(2022) Xiao-Xiao Yang et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

A deep learning model and human-machine fusion for prediction of EBV-associated gastric cancer from histopathology

(2022) Xueyi Zheng et al.   Nature Communications

Effect of neoadjuvant chemotherapy on the immune microenvironment in gastric cancer as determined by multiplex immunofluorescence and T cell receptor repertoire analysis

(2022) Xiaofang Xing et al.   Journal for ImmunoTherapy of Cancer

Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study

(2022) Haiping Jiang et al.   Journal for ImmunoTherapy of Cancer

An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGFβ blockade therapy

(2022) Robert Pomponio et al.   Acta Pharmaceutica Sinica B

DEMoS: a deep learning-based ensemble approach for predicting the molecular subtypes of gastric adenocarcinomas from histopathological images

(2022) Yanan Wang et al.   BIOINFORMATICS

Unsupervised domain selective graph convolutional network for preoperative prediction of lymph node metastasis in gastric cancer

(2022) Yongtao Zhang et al.   MEDICAL IMAGE ANALYSIS

Artificial intelligence-based prediction of clinical outcome in immunotherapy and targeted therapy of lung cancer

(2022) Xiaomeng Yin et al.   SEMINARS IN CANCER BIOLOGY

Neoadjuvant immunotherapy in gastrointestinal cancers – The new standard of care?

(2022) Branka Petricevic et al.   SEMINARS IN CANCER BIOLOGY

Targeting inflamed and non-inflamed melanomas: biological background and clinical challenges

(2022) Alice Indini et al.   SEMINARS IN CANCER BIOLOGY

A deep learning-based model improves diagnosis of early gastric cancer under narrow band imaging endoscopy

(2022) Dehua Tang et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Artificial intelligence for diagnosing gastric lesions under white-light endoscopy

(2022) Xiang-Lei Yuan et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Utility of a deep learning model and a clinical model for predicting bleeding after endoscopic submucosal dissection in patients with early gastric cancer

(2022) Ji Eun Na et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Network-based machine learning approach to predict immunotherapy response in cancer patients

(2022) JungHo Kong et al.   Nature Communications

Deep neural network trained on gigapixel images improves lymph node metastasis detection in clinical settings

(2022) Shih-Chiang Huang et al.   Nature Communications

Machine Learning Improves the Prediction Rate of Non-Curative Resection of Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer

(2022) Hae-Ryong Yun et al.   Cancers

Evaluation of Epidermal Growth Factor Receptor 2 Status in Gastric Cancer by CT-Based Deep Learning Radiomics Nomogram

(2022) Xiao Guan et al.   Frontiers in Oncology

Cell graph neural networks enable the precise prediction of patient survival in gastric cancer

(2022) Yanan Wang et al.   npj Precision Oncology

Intraoperative Applications of Artificial Intelligence in Robotic Surgery: A Scoping Review of Current Development Stages and Levels of Autonomy

(2022) Baptiste Vasey et al.   ANNALS OF SURGERY

Immune cellular components and signaling pathways in the tumor microenvironment

(2022) Sasitorn Yenyuwadee et al.   SEMINARS IN CANCER BIOLOGY

Artificial intelligence in radiotherapy

(2022) Guangqi Li et al.   SEMINARS IN CANCER BIOLOGY

Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment

(2022) Yang Chen et al.   Nature Communications

An artificial intelligence model to predict survival and chemotherapy benefits for gastric cancer patients after gastrectomy development and validation in international multicenter cohorts

(2022) Xunjun Li et al.   International Journal of Surgery

Evaluating the Effects of An Artificial Intelligence System on Endoscopy Quality and Preliminarily Testing its Performance on Detecting Early Gastric Cancer: A Randomized Controlled Trial

(2021) Lianlian Wu et al.   ENDOSCOPY

Deep learning system for lymph node quantification and metastatic cancer identification from whole-slide pathology images

(2021) Yajie Hu et al.   Gastric Cancer

Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis

(2021) Xiaofei Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials

(2021) Anwaar Saeed et al.   Journal of Hematology & Oncology

Noninvasive Prediction of Occult Peritoneal Metastasis in Gastric Cancer Using Deep Learning

(2021) Yuming Jiang et al.   JAMA Network Open

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Applying a random projection algorithm to optimize machine learning model for predicting peritoneal metastasis in gastric cancer patients using CT images

(2021) Seyedehnafiseh Mirniaharikandehei et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a

(2021) Mei Wang et al.   ONCOGENE

Predicting gastric cancer outcome from resected lymph node histopathology images using deep learning

(2021) Xiaodong Wang et al.   Nature Communications

Endoscopist Diagnostic Accuracy in Detecting Upper-GI Neoplasia in the Framework of Artificial Intelligence Studies

(2021) Leonardo Frazzoni et al.   ENDOSCOPY

Artificial intelligence in diagnosis of gastric precancerous conditions by image-enhanced endoscopy: a multicenter, diagnostic study (with video)

(2021) Ming Xu et al.   GASTROINTESTINAL ENDOSCOPY

Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial

(2021) Raghav Sundar et al.   GUT

Establishing Machine Learning Models to Predict Curative Resection in Early Gastric Cancer with Undifferentiated Histology: Development and Usability Study

(2021) Chang Seok Bang et al.   JOURNAL OF MEDICAL INTERNET RESEARCH

Use of Endoscopic Images in the Prediction of Submucosal Invasion of Gastric Neoplasms: Automated Deep Learning Model Development and Usability Study

(2021) Chang Seok Bang et al.   JOURNAL OF MEDICAL INTERNET RESEARCH

Medical image recognition and segmentation of pathological slices of gastric cancer based on Deeplab v3+ neural network

(2021) Jing Wang et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Deep learning system compared with expert endoscopists in predicting early gastric cancer and its invasion depth and differentiation status (with videos)

(2021) Lianlian Wu et al.   GASTROINTESTINAL ENDOSCOPY

3D Multi-Attention Guided Multi-Task Learning Network for Automatic Gastric Tumor Segmentation and Lymph Node Classification

(2021) Yongtao Zhang et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial

(2021) Yelena Y Janjigian et al.   LANCET

Effect of a deep learning-based system on the miss rate of gastric neoplasms during upper gastrointestinal endoscopy: a single-centre, tandem, randomised controlled trial

(2021) Lianlian Wu et al.   Lancet Gastroenterology & Hepatology

A Simple Risk Scoring System for Predicting the Occurrence of Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection

(2021) Kyemyung Park et al.   ANESTHESIA AND ANALGESIA

Advances in clinical immunotherapy for gastric cancer

(2021) Kexin Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Characterization of gastric cancer stem-like molecular features, immune and pharmacogenomic landscapes

(2021) Chen Wei et al.   BRIEFINGS IN BIOINFORMATICS

Artificial intelligence versus expert endoscopists for diagnosis of gastric cancer in patients who underwent upper gastrointestinal endoscopy

(2021) Ryota Niikura et al.   ENDOSCOPY

Development and evaluation of a double-check support system using artificial intelligence in endoscopic screening for gastric cancer

(2021) Hirotaka Oura et al.   Gastric Cancer

Real-time use of artificial intelligence for diagnosing early gastric cancer by magnifying image-enhanced endoscopy: a multicenter diagnostic study (with videos)

(2021) Xinqi He et al.   GASTROINTESTINAL ENDOSCOPY

Second gastric cancer after curative endoscopic resection of differentiated-type early gastric cancer: post-hoc analysis of a single-arm confirmatory trial

(2021) Masao Yoshida et al.   GASTROINTESTINAL ENDOSCOPY

Application of an artificial neural network for predicting the potential chemotherapy benefit of patients with gastric cancer after radical surgery

(2021) Jun Lu et al.   SURGERY

Early Tumor-Immune Microenvironmental Remodeling and Response to Frontline Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer

(2021) Ryul Kim et al.   Cancer Discovery

Accurate diagnosis and prognosis prediction of gastric cancer using deep learning on digital pathological images: A retrospective multicentre study

(2021) Binglu Huang et al.   EBioMedicine

Development and Validation of a Deep Learning CT Signature to Predict Survival and Chemotherapy Benefit in Gastric Cancer

(2020) Yuming Jiang et al.   ANNALS OF SURGERY

Dual-energy CT–based deep learning radiomics can improve lymph node metastasis risk prediction for gastric cancer

(2020) Jing Li et al.   EUROPEAN RADIOLOGY

Deep learning radiomic nomogram can predict the number of lymph node metastasis in locally advanced gastric cancer: an international multi-center study

(2020) D. Dong et al.   ANNALS OF ONCOLOGY

Endoscopic three-categorical diagnosis of Helicobacter pylori infection using linked color imaging and deep learning: a single-center prospective study (with video)

(2020) Hirotaka Nakashima et al.   Gastric Cancer

Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging

(2020) Naohiro Yoshida et al.   GUT

Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer

(2020) Kohei Shitara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Image-enhanced endoscopy for gastric preneoplastic conditions and neoplastic lesions: a systematic review and meta-analysis

(2020) Marta Rodríguez-Carrasco et al.   ENDOSCOPY

A Deep Learning-based System for Identifying Differentiation Status and Delineating Margins of Early Gastric Cancer in Magnifying Narrow-band Imaging Endoscopy

(2020) Tingsheng Ling et al.   ENDOSCOPY

Development and validation of a deep learning system for ascites cytopathology interpretation

(2020) Feng Su et al.   Gastric Cancer

Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo-carmine dye contrast imaging

(2020) Sayaka Nagao et al.   GASTROINTESTINAL ENDOSCOPY

Deep learning analysis of the primary tumour and the prediction of lymph node metastases in gastric cancer

(2020) C. Jin et al.   BRITISH JOURNAL OF SURGERY

A deep learning risk prediction model for overall survival in patients with gastric cancer: A multicenter study

(2020) Liwen Zhang et al.   RADIOTHERAPY AND ONCOLOGY

Clinically applicable histopathological diagnosis system for gastric cancer detection using deep learning

(2020) Zhigang Song et al.   Nature Communications

Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer

(2020) Kohei Shitara et al.   JAMA Oncology

A pan-cancer analysis of HER2 index revealed transcriptional pattern for precise selection of HER2-targeted therapy

(2020) Ziteng Li et al.   EBioMedicine

Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019

(2019) Pedro Pimentel-Nunes et al.   ENDOSCOPY

British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma

(2019) Matthew Banks et al.   GUT

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

(2019) Jakob Nikolas Kather et al.   NATURE MEDICINE

Updated evaluation of endoscopic submucosal dissection versus surgery for early gastric cancer: A systematic review and meta-analysis

(2019) Qing Liu et al.   International Journal of Surgery

Tumor Immune Microenvironment and Chemosensitivity Signature for Predicting Response to Chemotherapy in Gastric Cancer

(2019) Yuming Jiang et al.   Cancer Immunology Research

Real-time artificial intelligence for detection of upper gastrointestinal cancer by endoscopy: a multicentre, case-control, diagnostic study

(2019) Huiyan Luo et al.   LANCET ONCOLOGY

Development and validation of a CT-based radiomic nomogram for preoperative prediction of early recurrence in advanced gastric cancer

(2019) Wenjuan Zhang et al.   RADIOTHERAPY AND ONCOLOGY

Phase III Trial Comparing Intraperitoneal and Intravenous Paclitaxel Plus S-1 Versus Cisplatin Plus S-1 in Patients With Gastric Cancer With Peritoneal Metastasis: PHOENIX-GC Trial

(2018) Hironori Ishigami et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

(2018) Seung Tae Kim et al.   NATURE MEDICINE

A radiomics approach to assess tumour-infiltrating CD8 cells and response to anti-PD-1 or anti-PD-L1 immunotherapy: an imaging biomarker, retrospective multicohort study

(2018) Roger Sun et al.   LANCET ONCOLOGY

Evaluation of an e-learning system for diagnosis of gastric lesions using magnifying narrow-band imaging: a multicenter randomized controlled study

(2017) Hiroyoshi Nakanishi et al.   ENDOSCOPY

Five-year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese Gastric Cancer Association (2001–2007)

(2017) Hitoshi Katai et al.   Gastric Cancer

Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Yoon-Koo Kang et al.   LANCET

Risk factors for bleeding after gastric endoscopic submucosal dissection: a systematic review and meta-analysis

(2016) Diogo Libânio et al.   GASTROINTESTINAL ENDOSCOPY

Overexpression and gene amplification of PD-L1 in cancer cells and PD-L1+ immune cells in Epstein–Barr virus-associated gastric cancer: the prognostic implications

(2016) Ruri Saito et al.   MODERN PATHOLOGY

High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection

(2015) Haruhisa Suzuki et al.   Gastric Cancer

Accuracy of multidetector-row CT in diagnosing lymph node metastasis in patients with gastric cancer

(2014) Takuro Saito et al.   EUROPEAN RADIOLOGY

Rates and Patterns of Recurrence after Curative Intent Resection for Gastric Cancer: A United States Multi-Institutional Analysis

(2014) Gaya Spolverato et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial

(2014) Hansjochen Wilke et al.   LANCET ONCOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Early phase II study of robot-assisted distal gastrectomy with nodal dissection for clinical stage IA gastric cancer

(2013) Masanori Tokunaga et al.   Gastric Cancer

Robotically-enhanced surgical anatomy enables surgeons to perform distal gastrectomy for gastric cancer using electric cautery devices alone

(2013) Hirokazu Noshiro et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

Robot-Assisted Endoscopic Submucosal Dissection Is Effective in Treating Patients With Early-Stage Gastric Neoplasia

(2012) Soo Jay Phee et al.   Clinical Gastroenterology and Hepatology

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET