Article
Chemistry, Organic
Mahmood Kamali
Summary: A new green method has been presented for the synthesis of novel derivatives pyrano[4,3-b]chromenes and chromeno[4,3-b]chromenes, which involves a one-pot three components condensation reaction using SnCl2.2H(2)O as a catalyst in ethanol at 60 degrees C. The syntheses offer operational simplicity, mild reaction conditions, environmentally friendly and easy workup.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Baofu Zhu, Jiaming He, Kai Zou, Anquan Li, Chen Zhang, Jiaji Zhao, Hua Cao
Summary: This study established a three-component reaction catalyzed by base, involving ynals, isocyanates, amines, and alcohols. The strategy enables a wide range of substrates and provides a simple process for the preparation of diverse pyridine derivatives with good yields and high regioselectivities.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Applied
Lukas Biesen, Thomas J. J. Mueller
Summary: Quinoxalines are nitrogen-containing bicyclic heterocycles with diverse biological activities and luminescence properties. Their syntheses involve a range of multicomponent methods, such as Ugi-reactions, leading to the development of novel reactions and sequences. Diversity-oriented synthesis and transition metal catalyzed multicomponent reactions offer efficient pathways to quinoxalines and quinoxaline-containing moieties.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Organic
Ali Ramazani, Mohammad Taghi Kiani, Sobhan Rezayati
Summary: This review article focuses on the significant reactions and applications of 5H-chromeno[2,3-b]pyridine derivatives, including two-component reactions, three-component reactions, four-component reactions, and multi-step reactions. It is expected to serve as a useful conceptual overview and inspire the next generation to develop different strategies for the preparation of 5H-chromeno[2,3-b]pyridine derivatives.
LETTERS IN ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Lan Bao, Yu Liu, Jinghan Peng, Yuan Wang, Jinhuan Dong, Xianxiu Xu
Summary: The catalyst-free chemoselective trimerization reaction of isocyanides leads to the formation of a wide range of 2-(indol-2-yl)-quinolines and 2-(indol-2-yl)-pyridines in moderate to excellent yields. The key step of this reaction is proposed to be the head to head heterodimerization of two isocyanides.
Article
Chemistry, Multidisciplinary
Prerna Ganwir, Priyanka Bandivadekar, Pawan Kudale, Ganesh U. Chaturbhuj
Summary: This study presents a rapid and efficient method for synthesizing polyhydroquinolines using the Hantzsch reaction and 2-amino-4H-chromene derivatives. The method is catalyst-free and uses ethanol: water (1:1) at room temperature and 90 degrees Celsius. It demonstrates the ability to handle diverse substrates with different functional groups, including ketones. Furthermore, this method offers economical and environmentally friendly advantages with shorter reaction time, simple workup procedure, no catalyst, and excellent yields.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Multidisciplinary
Mina Keihanfar, Bi Bi Fatemeh Mirjalili, Abdolhamid Bamoniri
Summary: In this research, a novel magnetic natural-based basic nanocatalyst Fe3O4@nano-almond shell@OSi(CH2)(3)/DABCO was synthesized and characterized. The catalyst was analyzed using various spectroscopy and microscopy techniques. It was employed for the one-pot synthesis of 2-amino-4H-benzo[f]chromenes-3-carbonitrile from the multicomponent reaction, achieving yields of 80-98%. This process offers attractive features such as easy work-up, mild reaction conditions, reusability of the catalyst, short reaction times, and excellent yields.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Lenida Kyndiah, Fillip Kumar Sarkar, Ajay Gupta, Amarta Kumar Pal
Summary: Graphite oxide was used as a catalyst for the synthesis of important pharmaceutical compounds under solvent-free reaction conditions. Spectroscopic techniques confirmed the formation and thermal stability of the catalyst, and the study showed that the method is environmentally friendly and sustainable.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Applied
Fatemeh Kalantari, Sobhan Rezayati, Ali Ramazani, MohammadReza Poor Heravi
Summary: Magnetic nanoparticles have been proven to be a powerful tool in achieving milder organic transformations and have shown potential in biomedical applications. They play a crucial role in human health, environmental protection, and energy resource management. The advantages of these catalysts include excellent reusability, easy separation, and stability, making detailed studies on their synthesis mechanism essential.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Avishek Guin, Subrata Bhattacharjee, Akkattu T. Biju
Summary: This study demonstrates the direct C2-functionalization of pyridines through a transition-metal-free protocol using aryne multicomponent coupling. The reaction allows for the synthesis of C2-substituted pyridine derivatives bearing the -CF3 group in good yields, with activated keto esters also being employed as third components in the formal 1,2-di(hetero)arylation of ketones. Performing the reaction under dilute conditions inhibits the competing pyridine-aryne polymerization pathway, leading to the desired products.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Li-Na Dong, Shuai-Zheng Zhang, Wan-Lu Zhang, Yao Dong, Li-Ping Mo, Zhan-Hui Zhang
Summary: In this study, a magnetic biochar sulfonic acid catalyst was successfully prepared and characterized. The catalyst exhibited excellent catalytic activity for the synthesis of spiro-pyrazolo[3,4-b]pyridine derivatives and could be easily recovered and reused without a significant decrease in catalytic performance.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Multidisciplinary
Sergey D. Batalin, Margarita A. Golikova, Alexandra A. Khrustaleva, Artem A. Bakal, Tatyana S. Ponomareva, Irina Yu Goryacheva
Summary: This study focuses on the synthesis and characterization of new derivatives of substituted 2-(ortho-hydroxyaryl)cyclopenta[b]pyridines. The research establishes a new synthetic pathway and examines the fluorescent properties of the obtained structures under different conditions, providing insights into their unique characteristics.
Review
Chemistry, Organic
Vikrant V. Kumbhar, Bhushan B. Khairnar, Manohar G. Chaskar, Ramdas A. Pawar, Gulab S. Gugale
Summary: Imidazo[1,2-a]pyridines are important nitrogen-containing heterocyclic scaffolds with wide applications in medicinal chemistry, organometallics, and material science. This review discusses the rigorous efforts made in the past decade towards the regioselective and straightforward synthesis of 3-aroyl and 2-aroyl imidazo[1,2-a]pyridines, as well as highlights the challenges in achieving regioselective aroylation at the C-2 position.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Maria I. L. Soares, Clara S. B. Gomes, M. Conceicao Oliveira, Joaquim Marcalo, Teresa M. V. D. Pinho e Melo
Summary: A new synthetic methodology using DABCO-catalyzed reaction has been developed to synthesize 5H-chromeno[3,4-b]pyridine derivatives with moderate to good yields (30-76%). Mechanistic studies by mass spectrometry helped identify key intermediates in the reaction mechanism, providing insights into the process.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kim-Thao Le, Jan J. Bandolik, Matthias U. Kassack, Kenneth R. Wood, Claudia Paetzold, Marc S. Appelhans, Claus M. Passreiter
Summary: The dichloromethane extract from leaves of Melicope barbigera from the Hawaiian island of Kaua'i yielded new acetophenones and 2H-chromenes, which showed moderate cytotoxic activities against the human ovarian cancer cell line A2780. The structures of the new compounds were elucidated by spectroscopic analyses, and the absolute configuration was determined using modified Mosher's method.
