Article
Chemistry, Inorganic & Nuclear
Asima Munawar, Helen Stoeckli-Evans, Anvarhussein A. Isab, Imran Rashid, Raja Shahid Ashraf, Muhammad Altaf
Summary: Three new heteroleptic silver(I) polymers were successfully synthesized and characterized. The structures of two polymers were determined by X-ray diffraction analysis. The synthesized polymers showed promising antimicrobial activity against both gram-negative and gram-positive bacteria, as well as antifungal activity against various fungi.
Article
Chemistry, Physical
Miyase Gozde Gunduz, Busra Kaya, Ceren Ozkul, Onur Sahin, Estharla Madhu Rekha, Dharmarajan Sriram, Bahri Ulkuseven
Summary: Novel thiosemicarbazone derivatives were synthesized, including an unexpected pyrazole derivative. These compounds were screened for antimicrobial activities and biofilm inhibition capacities, providing potential targets for further studies.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Review
Chemistry, Medicinal
Renata Paprocka, Malgorzata Wiese-Szadkowska, Tomasz Kosmalski, Daria Frisch, Magdalena Ratajczak, Bozena Modzelewska-Banachiewicz, Renata Studzinska
Summary: Amidrazones are widely used in chemical synthesis, industry and agriculture. This review summarizes the important findings on the biological activities of amidrazones from 2010 to 2022, including different categories of active compounds and their mechanisms. The review focuses on new compounds with potential as drugs and repurposing of old drugs with new therapeutic targets, highlighting the potential and significance of amidrazone derivatives in drug development.
Article
Chemistry, Multidisciplinary
Wen-Te Wu, Kwong-Kau Tiong, Yu-Wei Lee, Sheng-Yao Hu, Yueh-Chien Lee, Wei Huang
Summary: In this study, a series of Sm3+/Tb3+ co-doped CaMoO4 phosphors were synthesized by an efficient method of microwave-assisted heating. The research focused on the characterization and performance analysis of the synthesized phosphors. The results showed that the light-emitting region of the phosphors can be controlled by adjusting the molar ratio of Sm3+/Tb3+ ions, making them a promising material for color-tunable phosphors in white-LEDs.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Inorganic & Nuclear
Liu Ju, Wu Shuang, Wang Huan, Du Si-Yuan, Li Zhen, Shen Ji-Wei, Chen Ye, Ding Shi
Summary: A series of 2,4-diarylaminopyrimidine derivatives with pyridine structure were synthesized and their crystal structures were determined by X-ray diffraction. The bioassay results demonstrated that these compounds exhibited potential antiproliferative activities against various cell lines.
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Beatrice-Cristina Ivan, Stefania-Felicia Barbuceanu, Camelia Mia Hotnog, Adriana Iuliana Anghel, Robert Viorel Ancuceanu, Mirela Antonela Mihaila, Lorelei Irina Brasoveanu, Sergiu Shova, Constantin Draghici, Octavian Tudorel Olaru, George Mihai Nitulescu, Mihaela Dinu, Florea Dumitrascu
Summary: The current study synthesized a new series of pyrrole derivatives and characterized their physicochemical properties and cytotoxicity. The results indicated that some pyrrole derivatives exhibited cytotoxic activity against tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Chetan B. Palan, Nikhilesh S. Bajaj, Suresh P. Bhagat, Shrinivas K. Omanwar
Summary: In this study, hexagonal structured borate phosphors BaLaB9O16 were synthesized using a combustion method, with color-tunable emission properties achieved by doping Eu3+ and Tb3+. The materials were analyzed for structural and morphological parameters, with photoluminescence results showing good green and red emissions for Tb3+ and Eu3+ doping, respectively, and the co-doped sample exhibiting variable emission from green to red regions by adjusting the excitation wavelength.
Article
Chemistry, Multidisciplinary
Ghada S. Masaret
Summary: This study synthesized thiazolyl-pyrazole compounds and explored their potential biological activities through various reactions, demonstrating excellent antibacterial, antifungal, antioxidant, and antitumor activities.
Article
Chemistry, Physical
Harikrishnan Ravichandran, Baskaran Irusan, Sathyaseelan Balaraman, Mani Govindasamy, Senthilnathan Krishnamoorthy, Manikandan Elayaperumal
Summary: In this study, rare earth Erbium metal incorporated orthoferrite nanoparticles were successfully synthesized and characterized using microwave-assisted technique. The unit cell structure was confirmed to belong to the orthorhombic-cubic phase with slightly induced distortion in bond distance between atoms. The vibrational frequencies of Er-O and Fe-O groups were observed and calculated, with a band gap of 2.1 eV and weak ferromagnetic property observed in the synthesized nanoparticles.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Spectroscopy
Jasneet Rana, R. P. Chaudhary
Summary: In this study, Indenocarbothioamides 2 were synthesized from the reaction of indane-1,3-dione with aryl isothiocyanates, followed by condensation with 3-chloropentane-2,4-dione and chloroacetyl chloride to obtain thiazole and thiazolidin-5-one derivatives based on 1,3-indanedione. The structure of the obtained products was confirmed by spectral data and experimental studies.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Inorganic & Nuclear
J. Madona, C. Sridevi
Summary: The multilayer coral reef-like MgO/g-C3N4 nanocomposite synthesized by surfactant-assisted hydrothermal method exhibited superior photocatalytic and antibacterial activities, with stability and high degradation efficiency.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Yahya Asiri, Faiz A. Al-aizari, Nabila A. Kheder, Zainab M. Almarhoon, Hazem A. Ghabbour, Yahia N. Mabkhot
Summary: A convenient synthesis of novel pyrazolo[5,1-b]thiazole-based heterocycles was carried out in this study, and the synthesized compounds were characterized and evaluated for antimicrobial and anticancer activities, showing promising results. These products could potentially serve as leading compounds for future drug molecule design.
Review
Agriculture, Multidisciplinary
Fazlurrahman Khan, Nazia Tabassum, Nilushi Indika Bamunuarachchi, Young-Mog Kim
Summary: Phloroglucinol and its derivatives have been widely used to treat microbial infections and exhibit diverse biological activities. With the increasing resistance of microorganisms to antimicrobial drugs, the synthesis of more phloroglucinol derivatives is crucial to meet the growing demand. This review provides an overview of the application of phloroglucinol and its derivatives in antibacterial action and explores their potential future perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Miyanou Rosales-Hurtado, Valentin Duvauchelle, David Benimelis, Maya Ogawa-Okada, Naofumi Yamamoto, Patrick Meffre, Hendrik Szurmant, Zohra Benfodda
Summary: This study successfully synthesized a variety of antibacterial derivatives using microwave-assisted synthesis and found that two compounds exhibited good activity against pathogenic bacteria while being non-toxic and biodegradable to environmental bacteria.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Energy & Fuels
Chaoping Xu, He Li, Jiexin Lu, Yi Lu, Shiliang Shi, Qing Ye, Min Li, Zheng Wang
Summary: This paper presents a comprehensive analysis of the evolutionary characteristics of the macromolecular structure of coal using X-ray diffraction and Raman spectroscopy. The results show that microwave irradiation triggers the conversion of ordered graphitic carbon to amorphous carbon, as well as the condensation and spatial arrangement of aromatic clusters. Microwave-assisted oxidation facilitates the directional growth of aromatic rings and the cross-linking of aliphatic chains, and induces the rotation, displacement, stacking, and gradual parallel alignment of aromatic lamellae, thereby improving the integrity of the graphite structure and the orderliness of the macromolecular structure.
Article
Toxicology
Piotr Strus, Karol Borensztejn, Andrzej Antoni Szczepankiewicz, Kamil Lisiecki, Zbigniew Czarnocki, Hanna Nieznanska, Cezary Wojcik, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: The KL3 derivative of PPT is less toxic to non-cancerous cells compared to PPT, allowing for repair of normal cells and triggering mechanisms to restore cell homeostasis.
TOXICOLOGY IN VITRO
(2021)
Article
Chemistry, Multidisciplinary
Maciej Krzeszewski, Lukasz Dobrzycki, Andrzej L. Sobolewski, Michal K. Cyranski, Daniel T. Gryko
Summary: The synthesis of a bowl-shaped nitrogen-doped nanographene involves a concise strategy using multicomponent synthesis and sequential intramolecular direct arylation reactions with different reactivity of bonds, resulting in interesting properties in the final structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Joanna Olkowska-Truchanowicz, Agata Bialoszewska, Aneta Zwierzchowska, Alicja Sztokfisz-Ignasiak, Izabela Janiuk, Filip Dabrowski, Grazyna Korczak-Kowalska, Ewa Barcz, Katarzyna Bocian, Jacek Malejczyk
Summary: Peritoneal fluid from patients with endometriosis exhibits immunoregulatory/immunosuppressive activity, affecting T cell generation and cytokine balance. However, peritoneal milieu from non-patients may also have some immunoregulatory/immunosuppressive properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Joanna Olkowska-Truchanowicz, Alicja Sztokfisz-Ignasiak, Aneta Zwierzchowska, Izabela Janiuk, Filip Dabrowski, Grazyna Korczak-Kowalska, Ewa Barcz, Katarzyna Bocian, Jacek Malejczyk
Summary: The study found that the proportions of regulatory T cells are increased in the peritoneal fluid of women with endometriosis compared to controls. Endometriosis is also associated with elevated concentrations of various cytokines and chemokines. Regulatory T cells in the peritoneal cavity of endometriosis patients may be attracted and activated by local chemokines and cytokines, especially CCL20 and TGF-beta.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Damian Jagleniec, Natalia Walczak, Lukasz Dobrzycki, Jan Romanski
Summary: By utilizing a 4-nitro-L-phenylalanine scaffold, ion pair receptors capable of enhanced anion binding with the assistance of alkali metal cations were constructed. The receptors demonstrated strong interaction with salts in both organic and solid phases, with potential applications in drug development for treating channelopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Agata Gurba, Przemyslaw Taciak, Mariusz Sacharczuk, Izabela Mlynarczuk-Bialy, Magdalena Bujalska-Zadrozny, Jakub Fichna
Summary: Cancer is a major cause of illness and death worldwide. Colorectal cancer is the third most common cancer in men and the second most common in women. Standard antitumor therapies, such as cisplatin, have limitations due to their lack of specificity for tumor cells, drug resistance development, and severe side effects. Therefore, new methods and strategies for treating colorectal cancer are urgently needed. Current research focuses on novel platinum and other metal-based drugs, such as gold, silver, iridium, or ruthenium. Au(III) compounds are considered promising candidates for colorectal cancer treatment due to their structural similarity to Pt(II). However, their stability under physiological conditions needs improvement by combining with various ligands. This review summarizes the progress in developing stable Au(III) complexes with potential cytotoxic activity against cancer cells. Additionally, it highlights that the anticancer effects of Au derivatives are mediated by protein structures, such as thioredoxin reductase, rather than nucleic acids. The current state of in vivo studies is also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marta Zaleskaya-Hernik, Lukasz Dobrzycki, Marcin Karbarz, Jan Romanski
Summary: The anthracene functionalized squaramide dual-host receptor 1 selectively extracts sulfate salts, as evidenced by various measurements. In contrast, the reference receptor 3 without a crown ether unit loses the enhancement in anion binding induced by cations. The ability of receptor 1 to selectively detect sulfates in organic phase presents new possibilities in sensor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Karol Borensztejn, Pawel Tyrna, Agata M. Gawel, Ireneusz Dziuba, Cezary Wojcik, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Cell-in-cell (CIC) phenomenon, known for over 100 years, is experiencing a renaissance due to modern visualization techniques and its potential prognostic and diagnostic value for cancer patients. However, there are many unresolved questions and challenges in studying CIC, which involve complex cell interactions and molecular mechanisms.
Article
Biochemistry & Molecular Biology
Jakub Wlodarczyk, Julia Krajewska, Lukasz Szeleszczuk, Patrycja Szalwinska, Agata Gurba, Szymon Lipiec, Przemyslaw Taciak, Remigiusz Szczepaniak, Izabela Mlynarczuk-Bialy, Jakub Fichna
Summary: Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are global health problems with increasing frequency and unclear pathogenesis. Current treatment involves drugs like corticosteroids and derivative compounds, but more specific and effective therapies are desired. In this study, novel gold complexes were tested and found to have anti-inflammatory potential both in vitro and in vivo, particularly TGS 703, which was able to alleviate inflammation in a mouse model of colitis and showed a link to antioxidant systems. These findings suggest that gold(III) complexes may have therapeutic applications in the treatment of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maja Owe-Larsson, Jan Pawlasek, Tomasz Piecha, Alicja Sztokfisz-Ignasiak, Mikolaj Pater, Izabela R. Janiuk
Summary: The functions of CART neuropeptide encoded by the CARTPT gene range from modifying behavior and pain sensitivity to being an antioxidant. Recently, the putative CART peptide receptor GPR160 has been implicated in the pathogenesis of cancer. However, the exact role of CART protein in cancer development remains unclear. This systematic review analyzed 19 publications that describe the association of CART and cancer, suggesting its potential as a biomarker and its oncogenic role in various cancer types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ireneusz Dziuba, Agata M. Gawel, Pawel Tyrna, Jedrzej Machtyl, Monika Olszanecka, Andrzej Pawlik, Cezary Wojcik, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Homotypic entotic figures, a potential prognostic marker in various cancers, have unclear biological roles. This study aimed to explore and compare the frequency of entosis in primary breast tumors and their lymph node metastases. Additionally, we investigated the correlation between entosis and classical breast cancer biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Szymon Lipiec, Agata Gurba, Izabela M. Agnieszczak, Andrzej Antoni Szczepankiewicz, Przemyslaw Szymanski, Przemyslaw Taciak, Remigiusz Szczepaniak, Lukasz Szeleszczuk, Hanna Nieznanska, Jakub Wlodarczyk, Jakub Fichna, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Metal-based agents in cancer therapy, like cisplatin and its derivates, have established clinical applications but also can induce serious side effects. Thus, metallotherapeutic alternatives for platinum derivatives are developed and intensively studied. Platinum is replaced by several transition metals including gold. Especially gold (III) complexes can have the same square-planar structure and are isoelectric with platinum (II).
TOXICOLOGY IN VITRO
(2023)
Article
Biochemistry & Molecular Biology
Ireneusz Dziuba, Agata M. Gawel, Pawel Tyrna, Jolanta Rybczynska, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Homotypic entosis is the process where one cancer cell invades and entirely engulfs a neighboring cancer cell within a vacuole. This study analyzed the frequency and characteristics of entotic figures in a case of breast cancer in different locations, including the primary tumor, regional lymph node, and distant metastasis. The majority of entotic figures were found in the lymph node, followed by the primary tumor and far metastasis. Notably, entosis did not result in cell death in any location, and altered morphology was observed in the far metastases. Additionally, the study proposed additional criteria for identifying pro-survival entotic structures in diagnostic histopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physics, Multidisciplinary
D. Kalinowska, M. T. Klepka, A. Wolska, E. Hejchman, I Mlynarczuk-Bialy
Summary: The study successfully investigated the binding mechanism between Cu(II) ions and bioactive Schiff base derivative ligands, revealing a distorted square planar geometry around the Cu(II) ions with bidently coordinated ligands. Nitrogen and oxygen atoms were found to be active in the binding process, and three-dimensional molecular models were proposed for each complex studied.
ACTA PHYSICA POLONICA A
(2021)
Article
Chemistry, Multidisciplinary
Pawel Socha, Bernadeta Prus, Lukasz Dobrzycki, Roland Boese, Michal K. Cyranski
Summary: The structures and interactions of four new hydrates of substituted piperidines were investigated using X-ray crystallography and quantum chemistry. The study found that the number of hydrates significantly decreased with piperidine ring substitution. Despite structural differences, hydrates with different substitutions had the same melting temperature, and chlorine...chlorine interactions had no significant impact on the stability of the hydrates.
