Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment

Chromatin basis of the senescence-associated secretory phenotype

(2022) Xue Hao et al.   TRENDS IN CELL BIOLOGY

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression

(2022) Kenichi Miyata et al.   Nucleus

Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer

(2022) Mihir Rajurkar et al.   Cancer Discovery

GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer

(2022) Kohei Kumegawa et al.   npj Breast Cancer

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

(2022) Sho Sugawara et al.   Communications Biology

ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis

(2021) Jeffrey M. Granja et al.   NATURE GENETICS

The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence

(2021) Xianglin Zhang et al.   GENOME RESEARCH

Endothelial cells under therapy-induced senescence secrete CXCL11, which increases aggressiveness of breast cancer cells

(2020) Hyun Jung Hwang et al.   CANCER LETTERS

HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement

(2020) Maciej T. Nogalski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence

(2020) Ioana Olan et al.   Nature Communications

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer

(2019) Tze Mun Loo et al.   CANCER SCIENCE

Cancer statistics, 2018

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HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types

(2018) Anne Zirkel et al.   MOLECULAR CELL

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

(2018) Akiko Takahashi et al.   Nature Communications

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

(2017) M Ryan Corces et al.   NATURE METHODS

Senescent tumor cells lead the collective invasion in thyroid cancer

(2017) Young Hwa Kim et al.   Nature Communications

The Chromatin Landscape of Cellular Senescence

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Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells

(2015) Antoine Tanne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

(2015) Francesca Bersani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional landscape of repetitive elements in normal and cancer human cells

(2014) Steven W Criscione et al.   BMC GENOMICS

The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

(2014) Makoto Kuwahara et al.   Nature Communications

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence

(2013) Eric C. Swanson et al.   JOURNAL OF CELL BIOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Senescent cells harbour features of the cancer epigenome

(2013) Hazel A. Cruickshanks et al.   NATURE CELL BIOLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Repetitive DNA and next-generation sequencing: computational challenges and solutions

(2011) Todd J. Treangen et al.   NATURE REVIEWS GENETICS

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

(2011) D. T. Ting et al.   SCIENCE

Real-time in vivo imaging of p16Ink4areveals cross talk with p53

(2009) Kimi Yamakoshi et al.   JOURNAL OF CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY