Inhibition of Uterine Contractility by Thalidomide Analogs via Phosphodiesterase-4 Inhibition and Calcium Entry Blockade

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

(2014) P.H. Schafer et al.   CELLULAR SIGNALLING

The PDE4 Inhibitor Rolipram Prevents NF- B Binding Activity and Proinflammatory Cytokine Release in Human Chorionic Cells

(2014) R. Herve et al.   JOURNAL OF IMMUNOLOGY

Different effects of adenylyl cyclase activators and phosphodiesterases inhibitors on cervical cancer (HeLa) and breast cancer (MCF-7) cells proliferation

(2014) Davood Mahdian et al.   TOXICOLOGY MECHANISMS AND METHODS

Phosphorylation-mediated regulation of GEFs for RhoA

(2014) Maulik Patel et al.   Cell Adhesion & Migration

β1-adrenergic receptor antagonists signal via PDE4 translocation

(2013) Wito Richter et al.   EMBO REPORTS

Homologous desensitization of human histamine H3 receptors expressed in CHO-K1 cells

(2013) Angélica Osorio-Espinoza et al.   NEUROPHARMACOLOGY

The regulation of myosin phosphatase in pregnant human myometrium

(2012) Claire A. Hudson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors

(2012) Rajamohan R. Poondra et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein kinase A-mediated phosphorylation of RhoA on serine 188 triggers the rapid induction of a neuroendocrine-like phenotype in prostate cancer epithelial cells

(2012) Sarah E. Jones et al.   CELLULAR SIGNALLING

Rho-kinase mediates diphosphorylation of myosin regulatory light chain in cultured uterine, but not vascular smooth muscle cells

(2012) Hector N. Aguilar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: Studies on pregnant ratin vivoand on pregnant human myometriumin vitro

(2012) Judit Verli et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Pre-term births on the rise

(2012) Eugenie Samuel Reich   NATURE

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

(2011) Kirsty F. MacKenzie et al.   BIOCHEMICAL JOURNAL

Teratogenic effects of thalidomide: molecular mechanisms

(2011) Takumi Ito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of Inflammation and Infection in Preterm Birth

(2011) Jamie A. Bastek et al.   CLINICS IN PERINATOLOGY

Synergistic relaxing effect of the paracetamol and pyrilamine combination in isolated human myometrium

(2011) Mario I. Ortiz et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1)

(2011) C. A. Hudson et al.   MOLECULAR HUMAN REPRODUCTION

Physiological pathways and molecular mechanisms regulating uterine contractility

(2010) H. N. Aguilar et al.   HUMAN REPRODUCTION UPDATE

Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: Studies on pregnant rat uteri in vitro

(2010) Anna Klukovits et al.   LIFE SCIENCES

Quantification of Rapid Myosin Regulatory Light Chain Phosphorylation Using High-Throughput In-Cell Western Assays: Comparison to Western Immunoblots

(2010) Hector N. Aguilar et al.   PLoS One

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

(2009) Hon-Wah Man et al.   JOURNAL OF MEDICINAL CHEMISTRY

Utero-relaxant effect of PDE4-selective inhibitor alone and in simultaneous administration with β2-mimetic on oxytocin-induced contractions in pregnant myometrium

(2009) Sona Franova et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Thalidomide as a Multi-Template for Development of Biologically Active Compounds

(2008) Yuichi Hashimoto   ARCHIV DER PHARMAZIE