Article
Medicine, General & Internal
Vincenzo Russotto, Sheila Nainan Myatra, John G. Laffey, Elena Tassistro, Laura Antolini, Philippe Bauer, Jean Baptiste Lascarrou, Konstanty Szuldrzynski, Luigi Camporota, Paolo Pelosi, Massimiliano Sorbello, Andy Higgs, Robert Greif, Christian Putensen, Christina Agvald-Ohman, Athanasios Chalkias, Kristaps Bokums, David Brewster, Emanuela Rossi, Roberto Fumagalli, Antonio Pesenti, Giuseppe Foti, Giacomo Bellani
Summary: This observational study on intubation practices in critically ill patients from an international sample of 197 sites across 29 countries found that major adverse peri-intubation events, particularly cardiovascular instability, occurred frequently.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Gastroenterology & Hepatology
Linda C. Cummings, Chen Liang, Edward J. Mascha, Leif Saager, Zachary L. Smith, Sekar Bhavani, John J. Vargo, Kenneth C. Cummings
Summary: This study compared the effects of general anesthesia and sedation without planned intubation on the incidence of hypoxemia and hypotension during ERCP and explored risk factors for the conversion from sedation without planned intubation to general anesthesia. The results showed that general anesthesia was associated with a lower incidence of hypoxemia, while sedation without planned intubation was associated with a lower incidence of hypotension. However, neither approach showed a clear advantage in the combined incidence of hypoxemia and hypotension.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Pediatrics
Susanne Tippmann, Martin Haan, Julia Winter, Ann-Kathrin Muehler, Katharina Schmitz, Mascha Schoenfeld, Luise Brado, Seyed Hamidreza Mahmoudpour, Eva Mildenberger, Andre Kidszun
Summary: This study analyzed 258 consecutive intubation attempts in 197 patients, with 57.4% of attempts associated with at least one TIAE. Factors such as inexperience in intubation and equipment problems were predictive of TIAEs, while first attempt at intubation and the use of videolaryngoscopy were predictive of successful intubation without TIAEs.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, General & Internal
David Gaist, Stine Munk Hald, Luis Alberto Garcia Rodriguez, Anne Clausen, Soren Moller, Jesper Hallas, Rustam Al-Shahi Salman
Summary: This cohort study suggests that patients in Denmark with a prior nontraumatic intracerebral hemorrhage (ICH) have significantly higher rates of major adverse cardiovascular events (MACEs) compared to the general population. Optimal secondary prevention with blood pressure lowering and antithrombotic and statin therapies after an ICH should be given attention in clinical research and practice.
Article
Medicine, General & Internal
Jin Takahashi, Tadahiro Goto, Shigeki Fujitani, Hiroshi Okamoto, Yusuke Hagiwara, Hiroko Watase, Kohei Hasegawa
Summary: Airway obstruction was associated with a significantly lower first-pass success rate and a higher intubation-related adverse event rate in the ED, according to this multicenter prospective study.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Marc Kriege, Rene Rissel, Hazem El Beyrouti, Eric Hotz
Summary: Awake tracheal intubation was associated with a lower incidence of severe adverse events compared to anaesthetised tracheal intubation in critical care patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Anne M. Butler, Michael J. Durkin, Matthew R. Keller, Yinjiao Ma, William G. Powderly, Margaret A. Olsen
Summary: In the treatment of uncomplicated UTI in commercially insured women, nitrofurantoin has lower risks of adverse drug events and potential microbiome-related adverse events compared to other agents. The duration of treatment modifies the risk of potential microbiome-related adverse events.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Critical Care Medicine
Natalie Napolitano, Lee Polikoff, Lauren Edwards, Keiko M. Tarquinio, Sholeen Nett, Conrad Krawiec, Aileen Kirby, Nina Salfity, David Tellez, Gordon Krahn, Ryan Breuer, Simon J. Parsons, Christopher Page-Goertz, Justine Shults, Vinay Nadkarni, Akira Nishisaki
Summary: This study aimed to determine if apneic oxygenation (AO) delivered via nasal cannula during tracheal intubation (TI) reduces adverse TI-associated events (TIAEs) in children. The study found that AO utilization was associated with a lower incidence of adverse TIAEs, but after further adjusting for patient and provider characteristics, AO utilization was not independently associated with the occurrence of adverse TIAEs and the occurrence of hypoxemia was not different.
Article
Medicine, General & Internal
Alexis F. Guedon, Jean-Baptiste De Freminville, Tristan Mirault, Nassim Mohamedi, Bastien Rance, Natalie Fournier, Jean-Louis Paul, Emmanuel Messas, Guillaume Goudot
Summary: This study found that higher levels of lipoprotein(a) (Lp[a]) were independently associated with an increased risk of major adverse limb events in hospitalized patients.
Article
Immunology
Ning Jiang, Yue Yu, Min Zhang, Yu Tang, Dawei Wu, Shuhang Wang, Yuan Fang, Yu Zhang, Lin Meng, Yingying Li, Huilei Miao, Peiwen Ma, Huiyao Huang, Ning Li
Summary: This study found that specific HLA types may be associated with irAEs in specific organs and tissues, while HLA heterogeneity does not significantly influence the occurrence of irAEs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Casey Lee McAtee, Joseph Lubega, Kristen Underbrink, Kristen Curry, Pavlos Msaouel, Martha Barrow, Eyal Muscal, Timothy Lotze, Poyyapakkam Srivaths, Lisa R. Forbes, Carl Allen, Brooke Bernhardt
Summary: Rituximab, a commonly used immunotherapy in pediatrics, is well tolerated among young people with few serious adverse events. However, infections are common, leading to a prolonged period of B cell count recovery often lasting for longer than a year. Further strategies to prevent infections following rituximab should be explored.
Article
Critical Care Medicine
Jr John Giuliano, Ashwin Krishna, Natalie Napolitano, Josep Panisello, Asha C. Shenoi, Jr Ronald C. Sanders, Kyle Rehder, Awni Al-Subu, I. I. I. Calvin Brown, Lauren Edwards, Lisa Wright, Matthew Pinto, Ilana Harwayne-Gidansky, Simon Parsons, Amy Romer, Elizabeth Laverriere, Justine K. Shults, Nicole M. Yamada, Catharine Walsh, Vinay Nadkarni, Akira Nishisaki
Summary: A prospective multicenter interventional quality improvement study was conducted in ten PICUs in North America to evaluate the implementation of a video laryngoscope as a coaching device to reduce adverse tracheal intubation associated events (TIAEs). The results showed that the use of video laryngoscope was associated with a reduced rate of TIAEs.
CRITICAL CARE MEDICINE
(2023)
Review
Emergency Medicine
Jessica Downing, Isha Yardi, Christine Ren, Stephanie Cardona, Manahel Zahid, Kaitlyn Tang, Vera Bzhilyanskaya, Priya Patel, Ali Pourmand, Quincy K. Tran
Summary: Peri-intubation major adverse events (MAEs) are common in critically ill patients intubated outside the OR and PACU, with a prevalence of approximately 30%. The risk is higher in the ICU compared to the ED. Factors such as hemodynamic instability and airway protection influence the occurrence of MAEs.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Samantha Cotter, Jennie Wong, Neha Gada, Rajdeep Gill, S. Christopher Jones, Grace Chai, Daniel Foster, Mark Avigan, Mallika Mundkur
Summary: The study found an association between repeated or continuous administration of ketamine and hepatobiliary adverse events, especially in the context of growing ketamine sales. Increased awareness among clinicians may mitigate these adverse outcomes.
Article
Oncology
Kristen Mathias, Sherin Rouhani, Daniel Olson, Anne R. Bass, Thomas F. Gajewski, Pankti Reid
Summary: This article examines the clinical utility of rheumatic autoantibodies (rhAbs) in diagnosing immune-related adverse events (irAEs). The study finds a significant association between rhAbs and rheumatic irAEs, and shows that irAEs are linked to better overall survival.
