Multivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications

Building a Molecular Trap for a Serine Protease from Aptamer and Peptide Modules

(2016) Daniel M. Dupont et al.   BIOCONJUGATE CHEMISTRY

Light-up fluorophore–DNA aptamer pair for label-free turn-on aptamer sensors

(2016) Teru Kato et al.   CHEMICAL COMMUNICATIONS

Gold nanoparticles modified with self-assembled hybrid monolayer of triblock aptamers as a photoreversible anticoagulant

(2016) San-Shan Huang et al.   JOURNAL OF CONTROLLED RELEASE

Methods for Improving Aptamer Binding Affinity

(2016) Hijiri Hasegawa et al.   MOLECULES

Structural requirements of mono- and multivalent L-selectin blocking aptamers for enhanced receptor inhibition in vitro and in vivo

(2016) Sebastian B. Riese et al.   Nanomedicine-Nanotechnology Biology and Medicine

Translation and Clinical Development of Antithrombotic Aptamers

(2016) Shahid M. Nimjee et al.   Nucleic Acid Therapeutics

Aptamers Against Immunologic Targets: Diagnostic and Therapeutic Prospects

(2016) Mariya Vorobyeva et al.   Nucleic Acid Therapeutics

Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant

(2016) Erin E. Soule et al.   Nucleic Acid Therapeutics

A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry

(2016) Keith E Maier et al.   Molecular Therapy-Nucleic Acids

From selection hits to clinical leads: progress in aptamer discovery

(2016) Keith E Maier et al.   Molecular Therapy-Methods & Clinical Development

Multifunctional Aptamer–Silver Conjugates as Theragnostic Agents for Specific Cancer Cell Therapy and Fluorescence-Enhanced Cell Imaging

(2015) Hui Li et al.   ANALYTICAL CHEMISTRY

Dual aptamer-immobilized surfaces for improved affinity through multiple target binding in potentiometric thrombin biosensing

(2015) Tatsuro Goda et al.   BIOSENSORS & BIOELECTRONICS

Current approaches in SELEX: An update to aptamer selection technology

(2015) Mariia Darmostuk et al.   BIOTECHNOLOGY ADVANCES

Multivalent aptamer–RNA based fluorescent probes for carrier-free detection of cellular microRNA-34a in mucin1-expressing cancer cells

(2015) Jihyun Kim et al.   CHEMICAL COMMUNICATIONS

Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

(2015) John Bruno   MOLECULES

A Highlight of Recent Advances in Aptamer Technology and Its Application

(2015) Hongguang Sun et al.   MOLECULES

Nucleic Acid Aptamers: An Emerging Tool for Biotechnology and Biomedical Sensing

(2015) Ti-Hsuan Ku et al.   SENSORS

Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

(2015) Dongxi Xiang et al.   Theranostics

Facile Supermolecular Aptamer Inhibitors of L-Selectin

(2015) Elizabeth K. Chang et al.   PLoS One

A Systematic Study of the Features Critical for Designing a High Avidity Multivalent Aptamer

(2015) Xiaoching Zhao et al.   Nucleic Acid Therapeutics

Identification and Characterization of an Agonistic Aptamer Against the T Cell Costimulatory Receptor, OX40

(2015) Elizabeth D. Pratico et al.   Nucleic Acid Therapeutics

Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted Therapy

(2014) Hao Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aptamer-based biosensors for biomedical diagnostics

(2014) Wenhu Zhou et al.   ANALYST

Array-based Discovery of Aptamer Pairs

(2014) Minseon Cho et al.   ANALYTICAL CHEMISTRY

An ensemble of aptamers and antibodies for multivalent capture of cancer cells

(2014) Jinling Zhang et al.   CHEMICAL COMMUNICATIONS

Multivalent comb-type aptamer–siRNA conjugates for efficient and selective intracellular delivery

(2014) Hyundong Yoo et al.   CHEMICAL COMMUNICATIONS

Disposable surface plasmon resonance aptasensor with membrane-based sample handling design for quantitative interferon-gamma detection

(2014) Tsung-Liang Chuang et al.   LAB ON A CHIP

New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization

(2014) Abdullah Ozer et al.   Molecular Therapy-Nucleic Acids

Multivalent DNA Nanospheres for Enhanced Capture of Cancer Cells in Microfluidic Devices

(2013) Weian Sheng et al.   ACS Nano

A polyvalent aptamer system for targeted drug delivery

(2013) Zhiqing Zhang et al.   BIOMATERIALS

Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer

(2013) Parag Parekh et al.   BIOMATERIALS

Aptamers from Cell-Based Selection for Bioanalytical Applications

(2013) Weihong Tan et al.   CHEMICAL REVIEWS

Use of Oligonucleotide Aptamer Ligands to Modulate the Function of Immune Receptors

(2013) E. Gilboa et al.   CLINICAL CANCER RESEARCH

Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy

(2013) Cuichen Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

(2013) Sarah Shigdar et al.   SENSORS

Aptamer-Conjugated Multifunctional Nanoflowers as a Platform for Targeting, Capture, and Detection in Laser Desorption Ionization Mass Spectrometry

(2012) Ismail Ocsoy et al.   ACS Nano

Streptavidin binding bifunctional aptamers and their interaction with low molecular weight ligands

(2012) Thao T. Le et al.   ANALYTICA CHIMICA ACTA

Amplified surface plasmon resonance immunosensor for interferon-Gamma based on a streptavidin-incorporated aptamer

(2012) Chia-Chen Chang et al.   BIOSENSORS & BIOELECTRONICS

Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution

(2012) Kareem M. Ahmad et al.   NUCLEIC ACIDS RESEARCH

Bioinspired multivalent DNA network for capture and release of cells

(2012) W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrochemiluminescence biosensor for the assay of small molecule and protein based on bifunctional aptamer and chemiluminescent functionalized gold nanoparticles

(2011) Ying Chai et al.   ANALYTICA CHIMICA ACTA

Highly Efficient Control of Thrombin Activity by Multivalent Nanoparticles

(2011) Chia-Lun Hsu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bi-specific Aptamers Mediating Tumor Cell Lysis

(2011) Achim Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Polymeric Aptamers for Selective Cytotoxicity

(2011) Liu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigation of the Interaction between a Bivalent Aptamer and Thrombin by AFM

(2011) Lin Ge et al.   LANGMUIR

Targeting 4-1BB Costimulation to Disseminated Tumor Lesions With Bi-specific Oligonucleotide Aptamers

(2011) Fernando Pastor et al.   MOLECULAR THERAPY

RNA aptamers that functionally interact with green fluorescent protein and its derivatives

(2011) Bo Shui et al.   NUCLEIC ACIDS RESEARCH

Dual-Surface Modified Virus Capsids for Targeted Delivery of Photodynamic Agents to Cancer Cells

(2010) Nicholas Stephanopoulos et al.   ACS Nano

Commandeering a biological pathway using aptamer-derived molecular adaptors

(2010) Prabhat K. Mallik et al.   NUCLEIC ACIDS RESEARCH

An RNA-based transcription activator derived from an inhibitory aptamer

(2010) Shengchun Wang et al.   NUCLEIC ACIDS RESEARCH

A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia

(2010) Prabodhika R. Mallikaratchy et al.   NUCLEIC ACIDS RESEARCH

Sensitive Bifunctional Aptamer-Based Electrochemical Biosensor for Small Molecules and Protein

(2009) Chunyan Deng et al.   ANALYTICAL CHEMISTRY

Bifunctional combined aptamer for simultaneous separation and detection of thrombin

(2009) Tao Bing et al.   BIOSENSORS & BIOELECTRONICS

Affinity and Avidity in Antibody-Based Tumor Targeting

(2009) Stephen I. Rudnick et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Regulation of Thrombin Activity with a Bifunctional Aptamer and Hemin: Development of a New Anticoagulant and Antidote Pair

(2009) Jing Wang et al.   CHEMBIOCHEM

DeNAno: Selectable deoxyribonucleic acid nanoparticle libraries

(2009) Jason M. Steiner et al.   JOURNAL OF BIOTECHNOLOGY

Viral Capsid DNA Aptamer Conjugates as Multivalent Cell-Targeting Vehicles

(2009) Gary J. Tong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Composite RNA aptamers as functional mimics of proteins

(2009) D. Xu et al.   NUCLEIC ACIDS RESEARCH

Multifunctional Label-Free Electrochemical Biosensor Based on an Integrated Aptamer

(2008) Yan Du et al.   ANALYTICAL CHEMISTRY

Cancer Cell Targeting Using Multiple Aptamers Conjugated on Nanorods

(2008) Yu-Fen Huang et al.   ANALYTICAL CHEMISTRY

Bivalent Ligands with Long Nanometer-Scale Flexible Linkers†

(2008) Ling Tian et al.   BIOCHEMISTRY

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

(2008) James O. McNamara et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular assembly for high-performance bivalent nucleic acid inhibitor

(2008) Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improvement of Aptamer Affinity by Dimerization

(2008) Hijiri Hasegawa et al.   SENSORS

Parallel Analysis of Two Analytes in Solutions or on Surfaces by Using a Bifunctional Aptamer: Applications for Biosensing and Logic Gate Operations

(2007) Johann Elbaz et al.   CHEMBIOCHEM