Inhibition of Urease by Disulfiram, an FDA-Approved Thiol Reagent Used in Humans

Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR) γ partial agonists

(2016) T. Kaserer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A combined temperature-pH study of urease kinetics. Assigning pKa values to ionizable groups of the active site involved in the catalytic reaction

(2016) Barbara Krajewska   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Using an Old Drug to Target a New Drug Site: Application of Disulfiram to Target the Zn-Site in HCV NS5A Protein

(2016) Yu-Ming Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Occurrence and fate of nitrification and urease inhibitors in the aquatic environment

(2016) Marco Scheurer et al.   Environmental Science-Processes & Impacts

Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner

(2015) Alex G. Dalecki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduction of Urease Activity by Interaction with the Flap Covering the Active Site

(2015) Lee Macomber et al.   Journal of Chemical Information and Modeling

Biological evaluation and molecular docking of baicalin and scutellarin as Helicobacter pylori urease inhibitors

(2015) Xiao-Dan Yu et al.   JOURNAL OF ETHNOPHARMACOLOGY

An overview on the potential of natural products as ureases inhibitors: A review

(2015) Luzia V. Modolo et al.   Journal of Advanced Research

Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach

(2014) Elena Cichero et al.   Chemical Biology & Drug Design

Structural Basis for Inactivation ofGiardia lambliaCarbamate Kinase by Disulfiram

(2014) Andrey Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Dynamics Study of Helicobacter pylori Urease

(2014) Mona S. Minkara et al.   Journal of Chemical Theory and Computation

A New Urease Inhibitor from Viola betonicifolia

(2014) Naveed Muhammad et al.   MOLECULES

The Emerging Role of Urease as a General Microbial Virulence Factor

(2014) Julian C. Rutherford   PLoS Pathogens

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates

(2013) Jed W. Fahey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Homology Modeling, Docking Studies and Molecular Dynamic Simulations Using Graphical Processing Unit Architecture to Probe the Type-11 Phosphodiesterase Catalytic Site: A Computational Approach for the Rational Design of Selective Inhibitors

(2013) Elena Cichero et al.   Chemical Biology & Drug Design

Nonredox Nickel Enzymes

(2013) Michael J. Maroney et al.   CHEMICAL REVIEWS

Inactivation of jack bean urease by scutellarin: Elucidation of inhibitory efficacy, kinetics and mechanism

(2013) Dian-Wei Wu et al.   FITOTERAPIA

Jack bean urease inhibition by crude juices of Allium and Brassica plants. Determination of thiosulfinates

(2013) Zofia Olech et al.   FOOD CHEMISTRY

Structural and functional studies on urease from pigeon pea (Cajanus cajan)

(2013) Anuradha Balasubramanian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design

(2013) Stefano Benini et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

High throughput colorimetric assay for rapid urease activity quantification

(2013) Tugba Onal Okyay et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Kinetics and Mechanism Study of Competitive Inhibition of Jack-Bean Urease by Baicalin

(2013) Lirong Tan et al.   TheScientificWorldJOURNAL

Growth-Inhibiting, Bactericidal, and Urease Inhibitory Effects of Paeonia lactiflora Root Constituents and Related Compounds on Antibiotic-Susceptible and -Resistant Strains of Helicobacter pylori

(2012) Luong Thi My Ngan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Temperature- and pressure-dependent stopped-flow kinetic studies of jack bean urease. Implications for the catalytic mechanism

(2012) Barbara Krajewska et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Wide-Open Flaps Are Key to Urease Activity

(2012) Benjamin P. Roberts et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antioxidant and urease inhibitoryC-glycosylflavonoids fromCeltis africana

(2011) Shagufta Perveen et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

The disulfiram metabolites S-methyl-N,N-diethyldithiocarbamoyl sulfoxide and S-methyl-N,N-diethylthiocarbamoyl sulfone irreversibly inactivate betaine aldehyde dehydrogenase from Pseudomonas aeruginosa, both in vitro and in situ, and arrest bacterial growth

(2010) Víctor J. Zaldívar-Machorro et al.   BIOCHIMIE

5-Hydroxy-1,4-naphthoquinone (juglone) and 2-hydroxy-1,4-naphthoquinone (lawsone) influence on jack bean urease activity: Elucidation of the difference in inhibition activity

(2010) Mirosława Kot et al.   BIOORGANIC CHEMISTRY

Urease inhibitors fromHypericum oblongifoliumWALL.

(2010) Mohammad Arfan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Ureases I. Functional, catalytic and kinetic properties: A review

(2009) Barbara Krajewska   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Insights into the role and structure of plant ureases

(2007) Cristian Follmer   PHYTOCHEMISTRY