Article
Chemistry, Multidisciplinary
Fei-Fei Wang, Jia-Hui Li, Hai-Yan Liu, Shu-Ping Deng, Ying-Ying Liu, Jian-Fang Ma
Summary: Three distinctive coordination polymers were solvothermally synthesized using a resorcin[4]arene ligand. Among them, compound 1 showed efficient and selective catalytic performance, and could be recycled with preservation of its catalytic capability and structural integrity.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Borja Cirera, Alexander Riss, Pingo Mutombo, Jose Urgel, Jose Santos, Marco Di Giovannantonio, Roland Widmer, Samuel Stolz, Qiang Sun, Max Bommert, Roman Fasel, Pavel Jelinek, Willi Auwarter, Nazario Martin, David Ecija
Summary: The design of organometallic complexes is crucial in modern organic chemistry and catalysis. On-surface synthesis has recently emerged as a disruptive method to design compounds and nanomaterials previously considered impossible. The activation of inner diacetylene moieties of a molecular precursor by copper surface adatoms has led to the formation of unprecedented organocopper metallacycles on Cu(111), paving the way for new avenues in organometallic compound engineering and polyyne chemistry on surfaces.
Correction
Chemistry, Inorganic & Nuclear
Firdaus Rahaman Gayen, Abdul Aziz Ali, Debashree Bora, Saptarshi Roy, Supriya Saha, Lakshi Saikia, Rajib Lochan Goswamee, Biswajit Saha
Summary: This study focuses on the synthesis and characterization of a ferrocene functionalized Schiff base containing Cu(II) complex, and demonstrates its catalytic activity in the azide alkyne cycloaddition reaction at parts-per-million levels.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Organic
Weiguang Yang, Yu Zhao, Qingxia Bu, Li Li, Baojing Zhou, Zunnan Huang
Summary: A novel synthesis method has been developed for functionalized dihydrooxazines through a tandem reaction under mild conditions. The involvement of N-sulfonyl acylketenimines in [4 + 2] cycloadditions is a notable feature, and the resulting dihydrooxazines can be converted to 2-aminopyridines under basic conditions.
Article
Biochemistry & Molecular Biology
Rebeka Jojart, Seyyed Ashkan Senobar Tahaei, Peter Trungel-Nagy, Zoltan Kele, Renata Minorics, Gabor Paragi, Istvan Zupko, Erzsebet Mernyak
Summary: Newly synthesised brominated and phosphonated compounds were investigated for their antiproliferative activities against human cancer cell lines. One of the compounds showed substantial selective cell growth-inhibitory activity against the A2780 cell line and strong interactions with tubulin binding sites. The disturbance of tubulin function was confirmed by photometric polymerisation assay.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Robby Vroemans, Sergio R. Ribone, Joice Thomas, Luc Van Meervelt, Thierry Ollevier, Wim Dehaen
Summary: A new method for preparing novel homochiral atropisomeric sulfanyl- and sulfoxide-substituted naphthyltriazoles is described in this study, providing a new pathway for stable 1,2,3-triazole-based atropisomers. Sixteen sulfanyl-substituted naphthyltriazoles were obtained via triazolization reaction, followed by monooxidation. The absolute configuration of the substituted naphthyltriazoles was determined using X-ray crystallography and confirmed with computational DFT calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Review
Chemistry, Physical
Chang-Qing Qin, Cheng Zhao, Guo-Shu Chen, Yun-Lin Liu
Summary: Catalytic enantioselective azide-alkyne cycloaddition (E-AAC) is an efficient technology for constructing diverse chiral triazoles, with applications in synthetic and medicinal chemistry, biological chemistry, and materials science. Significant developments have been made in copper-, nickel-, iridium-, and rhodium-catalyzed E-AAC reactions in the past six years. This review summarizes these advancements according to different strategies implemented.
Article
Chemistry, Multidisciplinary
Javed R. Pathan, Kana M. Sureshan
Summary: This study presents a simple, greener, and catalyst-free solid-state synthesis of unsaturated polyamides via a topochemical azide-alkyne cycloaddition reaction. Characterization of the reaction using various time-dependent techniques was conducted, showing the successful formation of unsaturated polyfumaramides. The study demonstrates the potential for post-synthetic modifications, such as cross-linking via light-induced cycloaddition reactions, utilizing the unsaturation present in the polymer structures.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Applied
Hakimeh Mirzaei, Hossein Eshghi, Seyed Mohammad Seyedi
Summary: The copper immobilized on silk fibroin was successfully prepared and characterized using multiple techniques, showing good catalytic activity in the azide-alkyne cycloaddition reaction under mild conditions. The heterogeneous-supported Cu catalyst showed stable catalytic activity after being reused four times.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Asmaa Yousofvand, Mojtaba Amini, Mojtaba Hosseinifard, Jan Janczak
Summary: A new polyoxomolybdate compound was synthesized, characterized, and used as a catalyst for the azide-alkyne cycloaddition reaction with high yields. The compound consists of [Co(H2O)6]2+ and N-methyluroptropine cations, a polyanion [C6H12N2CoMo6O24]4-, and lattice water molecules.
Article
Biochemistry & Molecular Biology
Kowit Hengphasatporn, Benyapa Kaewmalai, Somruedee Jansongsaeng, Vishnu Nayak Badavath, Thanaphon Saelee, Thamonwan Chokmahasarn, Tanatorn Khotavivattana, Yasuteru Shigeta, Thanyada Rungrotmongkol, Siwaporn Boonyasuppayakorn
Summary: Flavonoids, particularly modified apigenin, show anti-dengue activity by interfering with viral translation. Chemical modification allows for visualization of the compound in subcellular compartments. Molecular docking suggests binding of apigenin to ribosomal protein S9 and potential targets such as estrogen receptor 1 and viral NS1. These interactions attenuate dengue productivity by suppressing viral protein trafficking to the cell surface.
Article
Chemistry, Organic
Carl T. Bormann, Christeena Mathew, Margarida M. Antonio, Aude Trotti, Farzaneh Fadaei-Tirani, Kay Severin
Summary: In this study, the synthesis of a terminal 1-alkynyl triazene is described, and subsequent functionalization expands the structural diversity of this compound class. Furthermore, its applications in the synthesis of di- and triynes, as well as in the preparation of (hetero)aromatic triazenes through metal-catalyzed cyclization reactions, are explored.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xiai Luo, Yu Zhao, Susu Tao, Zhong-Tao Yang, Hui Luo, Weiguang Yang
Summary: A simple synthesis method for (Z)-1,2-dihydro-2-iminoquinolines has been achieved using copper-catalyzed reaction of 1-(2-aminophenyl)ethan-1-ones, sulfonyl azides, and terminal ynones under mild conditions. The Z-configured products are obtained through a base-free CuAAC/ring-opening process due to hydrogen bonding.
Review
Biochemistry & Molecular Biology
P. Rahul, Joice Thomas, Wim Dehaen, Jubi John
Summary: This review summarizes several reports on the synthesis of fused 1,2,3-triazole containing scaffolds using a sequential multicomponent reaction-intramolecular azide-alkyne cycloaddition approach. The reactions were carefully designed to incorporate azide and alkyne functionalities in the MCR product, which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction, and provides a critical discussion and analysis of the advantages and disadvantages of each methodology.
Article
Chemistry, Physical
Zohreh Esmaeeli, Mohammad Reza Khodabakhshi, Zohreh Mirjafary, Hamid Saeidian
Summary: A new family of 1, 2, 3-triazole-based benzodiazepines has been successfully synthesized by the Huisgen [3+2] dipolar cycloaddition reaction in aqueous medium, with mild reaction conditions, excellent yields, and environmentally-friendly features. Density functional theory calculations were conducted on the characterized structure 6a, providing structural, electronic, and thermodynamic data which were further interpreted using computational methods.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
