Journal
MOLECULES
Volume 21, Issue 7, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules21070870
Keywords
hyperspectral; data; fusion; vibration; spectroscopic; imaging; multivariate; chemometrics
Funding
- European Research Council (ERC) [335508-BioWater]
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Chemical image fusion refers to the combination of chemical images from different modalities for improved characterisation of a sample. Challenges associated with existing approaches include: difficulties with imaging the same sample area or having identical pixels across microscopic modalities, lack of prior knowledge of sample composition and lack of knowledge regarding correlation between modalities for a given sample. In addition, the multivariate structure of chemical images is often overlooked when fusion is carried out. We address these challenges by proposing a framework for multivariate chemical image fusion of vibrational spectroscopic imaging modalities, demonstrating the approach for image registration, fusion and resolution enhancement of chemical images obtained with IR and Raman microscopy.
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