Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Small-molecule kinase inhibitors: an analysis of FDA-approved drugs

(2016) Peng Wu et al.   DRUG DISCOVERY TODAY

Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease

(2016) Mudasir Maqbool et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and molecular modelling studies of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors

(2015) Yvonnick Loidreau et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

(2015) Ramzi Abbassi et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis of polyfunctionalized benzo[ d ]thiazoles as novel anthranilic acid derivatives

(2015) Damien Hédou et al.   TETRAHEDRON LETTERS

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

DYRK1A: A Potential Drug Target for Multiple Down Syndrome Neuropathologies

(2014) Walter Becker et al.   CNS & Neurological Disorders-Drug Targets

Human CDC2-Like Kinase 1 (CLK1): A Novel Target for Alzheimer’s Disease

(2014) Princi Jain et al.   CURRENT DRUG TARGETS

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors

(2014) Oussama Dehbi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

(2014) Alicia Foucourt et al.   MOLECULES

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

(2014) Alicia Foucourt et al.   MOLECULES

Rational multistep synthesis of a novel polyfunctionalized benzo[d]thiazole and its thiazolo[5,4-b]pyridine analogue

(2014) Damien Hédou et al.   TETRAHEDRON

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4

(2014) Christian Schmitt et al.   ACS Medicinal Chemistry Letters

Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315

(2013) Thomas C. Coombs et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel synthesis of angular thiazolo[5,4-f] and [4,5-h]quinazolines, preparation of their linear thiazolo[4,5-g] and [5,4-g]quinazoline analogs

(2013) Damien Hédou et al.   TETRAHEDRON

Convenient one-pot synthesis of N3-substituted pyrido[2,3-d]-, pyrido[3,4-d]-, pyrido[4,3-d]-pyrimidin-4(3H)-ones, and quinazolin-4(3H)-ones analogs

(2013) Emmanuel Deau et al.   TETRAHEDRON LETTERS

Recent developments of protein kinase inhibitors as potential AD therapeutics

(2013) Volkmar Tell et al.   Frontiers in Cellular Neuroscience

The Protein Interaction Landscape of the Human CMGC Kinase Group

(2013) Markku Varjosalo et al.   Cell Reports

Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

(2012) Breland Smith et al.   ACS Chemical Neuroscience

Tau protein kinases: Involvement in Alzheimer's disease

(2012) Ludovic Martin et al.   AGEING RESEARCH REVIEWS

Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors

(2012) Yvonnick Loidreau et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases

(2012) Yvonnick Loidreau et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multi-Target-Directed Ligands in Alzheimer's Disease Treatment

(2011) M. Bajda et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, Protein Kinase Inhibitory Potencies, and in Vitro Antiproliferative Activities of Meridianin Derivatives

(2011) Francis Giraud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-accelerated Dimroth rearrangement for the synthesis of 4-anilino-6-nitroquinazolines. Application to an efficient synthesis of a microtubule destabilizing agent

(2010) Alicia Foucourt et al.   TETRAHEDRON

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: Synthesis, biological evaluation and molecular modeling studies

(2007) Cédric Logé et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY