Journal
MOLECULES
Volume 21, Issue 3, Pages -Publisher
MDPI AG
DOI: 10.3390/molecules21030302
Keywords
Citrus; xanthine oxidase; aurantii fructus immaturus; hesperetin
Funding
- Fostering Plan for Outstanding Young Teachers in College of Meicine of Qingdao University
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Xanthine oxidase is a key enzyme which can catalyze hypoxanthine and xanthine to uric acid causing hyperuricemia in humans. Xanthine oxidase inhibitory activities of 24 organic extracts of four species belonging to Citrus genus of the family Rutaceae were assayed in vitro. Since the ethyl acetate extract of C. aurantium dried immature fruits showed the highest xanthine oxidase inhibitory activity, chemical evidence for the potent inhibitory activity was clarified on the basis of structure identification of the active constituents. Five flavanones and two polymethoxyflavones were isolated and evaluated for inhibitory activity against xanthine oxidase in vitro. Of the compounds, hesperetin showed more potent inhibitory activity with an IC50 value of 16.48 M. For the first time, this study provides a rational basis for the use of C. aurantium dried immature fruits against hyperuricemia.
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