Article
Multidisciplinary Sciences
Nils Radecker, Claudia Pogoreutz, Hagen M. Gegner, Anny Cardenas, Florian Roth, Jeremy Bougoure, Paul Guagliardo, Christian Wild, Mathieu Pernice, Jean-Baptiste Raina, Anders Meibom, Christian R. Voolstra
Summary: The altered nutrient cycling during heat stress is found to be a primary driver of the functional breakdown of coral-algal symbiosis. Energy limitation and altered symbiotic nutrient cycling are key factors in the early heat stress response, directly contributing to the breakdown of the coral-algal symbiosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Andrea Gamba, Daniel Petras, Mark Little, Brandie White, Pieter C. Dorrestein, Forest Rohwer, Rachel A. Foster, Aaron C. Hartmann
Summary: Untargeted metabolomics is a powerful tool for profiling the biochemical phenotypes of organisms and discovering new metabolites that can be developed into pharmaceuticals. This study demonstrates the use of tissue separation to simplify biological complexity and reveals different responses to environmental stress in coral host mitochondria and algal symbionts.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Cell Biology
Dora L. Cano-Ramirez, Laura Carmona-Salazar, Francisco Morales-Cedillo, Jorge Ramirez-Salcedo, Edgar B. Cahoon, Marina Gavilanes-Ruiz
Summary: The lipid matrix in cell membranes is dynamic and plays a role in membrane fluidity changes in response to temperature fluctuation. The plasma membrane (PM) of plants is highly fluid and sensitive to temperature variations, serving as an ideal temperature detector with the ability to quickly adjust in response to small temperature changes. This makes the PM an optimal alternative for temperature detection in plants.
Article
Biochemistry & Molecular Biology
Tatyana Sikorskaya, Kseniya Efimova, Andrey B. Imbs
Summary: The study analyzed and compared the lipidomes of symbiotic dinoflagellates isolated from two types of cnidarians, revealing that the composition of glycolipids is species-specific and not influenced by the host's taxonomic position. On the other hand, the profile of betaine lipids may be affected by the host. Additionally, the molecular species of triacylglycerols from freshly isolated symbiotic dinoflagellates were determined for the first time, showing different acyl group compositions based on their position.
Article
Biochemical Research Methods
Judith Fischer, Mascha Treblin, Tobias Sitz, Sascha Rohn
Summary: The use of algae and cyanobacteria in human nutrition is becoming increasingly important, with health effects believed to be influenced by minor components such as sulfolipids. Studies have found compounds like sulfoquinovosyldiacylglycerols (SQDGs) to play a role in the health effects of algae and cyanobacteria.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Hongchuan Liu, Huaihuai Dong, Liangjun Guo, Yongsheng Jin, Lihong Liu
Summary: Based on the experimental results, it was found that the administration of DHM did not significantly alter the pharmacokinetic characteristics of FLC in SD rat plasma.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Ping Du, Guo-yong Wang, Rui Zhao, Zhuo-ling An, Li-hong Liu
Summary: After rats were treated with remdesivir, significant changes were observed in the eicosanoid metabolic profiles, particularly in inflammatory and immunology-related metabolites. There was a significant correlation between drug metabolites and pharmacokinetic parameters. These findings provide mechanistic insights into COVID-19 treatment and SARS-CoV-2 virus infection.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Mauricio G. Martin, Carlos G. Dotti
Summary: One characteristic of aging is a decline in cell responsiveness to external stimuli, particularly in pathways controlled by hormones. This decline is associated with reduced receptor response to ligands, and it has been observed for hormones such as insulin, leptin, thyroid hormones, and glucocorticoids. This age-related resistance is also seen in adrenergic receptors, adenosine A2B receptor, and other G-protein-coupled receptors. The loss of receptors and changes in lipid composition of neuronal plasma membrane are proposed mechanisms for the decreased sensitivity to hormones and neurotransmitters. The altered membrane properties may contribute to physiological decline, decreased brain function, and increased vulnerability to neuropathology in aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vassiliki G. Kontogianni, Ioannis P. Gerothanassis
Summary: This review critically analyzes various methods for lipid hydroperoxide analysis and emphasizes analytical and structural methods that significantly contribute to the molecular basis of lipid hydroperoxide formation without the need for isolation of individual components.
Article
Chemistry, Analytical
Jihyun Won, Juhyung Kang, Wonku Kang
Summary: A quantitative determination method for ICG-001 in rat plasma was established using HPLC-MS/MS, confirming stability and pharmacokinetic behavior. The method met FDA-approved bioanalytical method criteria and was successfully applied in a pharmacokinetic study following subcutaneous and intravenous administration.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Analytical
Jihyun Won, Juhyung Kang, Wonku Kang
Summary: A quantitative determination method for ICG-001 in rat plasma was successfully established using HPLC-MS/MS. The method demonstrated stability and provided insights into the pharmacokinetics of ICG-001.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Nutrition & Dietetics
Maurice A. G. M. Kroon, Jacqueline K. Berbee, Soumia Majait, Eleonora L. Swart, Olaf van Tellingen, Hanneke W. M. van Laarhoven, E. Marleen Kemper
Summary: The oral intake of curcumin supplements still cannot reach therapeutic plasma levels. Healthcare practitioners need to be skeptical of the claimed beneficial systemic health effects of current curcumin supplement use by their patients.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Pottabattula Mahesh, M. Akiful Haque, Baher I. I. Salman, Tarek S. S. Belal, Adel Ehab Ibrahim, Sami El Deeb
Summary: Plaque psoriasis is a chronic skin condition with significant negative impacts on physical health, well-being, and work ability. Deucravacitinib (DEU), an oral Janus kinase (JAK) inhibitor, is the first medication used for its treatment. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach was used to analyze DEU in plasma samples, with trimethoprim as an internal standard (IS) and liquid-liquid extraction (LLE) for the separation of DEU and IS.
Article
Biochemical Research Methods
Cong Xi, Hua Zhao, Xue Lu, Tian-Jing Cai, Shuang Li, Ke-Hui Liu, Mei Tian, Qing-Jie Liu
Summary: The study utilized high-coverage targeted lipidomics to screen radiosensitive lipids, showing good sensitivity and specificity in triaging different radiation exposure levels by combined lipids. A novel strategy for radiation early triage and dose estimation was established using lipid panels, suggesting the feasibility of using targeted lipidomics for rapid, high-throughput triage in radiation biodosimetry.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Chemistry, Analytical
Ping Du, Lingling Xuan, Zhuoling An, Yuhui Zhang
Summary: MRTX849 is a novel targeted inhibitor of KRAS (G12C) that improves the response rate in patients with advanced solid tumors. This study reports an analytical HPLC-MS/MS assay and pharmacokinetics for MRTX849 in plasma, demonstrating the accuracy and validity of the method.
Article
Chemistry, Medicinal
T. V. Sikorskaya
CHEMISTRY OF NATURAL COMPOUNDS
(2020)
Review
Biochemistry & Molecular Biology
T. V. Sikorskaya, A. B. Imbs
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
(2020)
Review
Chemistry, Medicinal
Ekaterina Ermolenko, Andrey B. Imbs, Tatyana A. Gloriozova, Vladimir V. Poroikov, Tatyana Sikorskaya, Valery M. Dembitsky
Article
Biochemistry & Molecular Biology
Tatyana Sikorskaya, Kseniya Efimova, Andrey B. Imbs
Summary: The study analyzed and compared the lipidomes of symbiotic dinoflagellates isolated from two types of cnidarians, revealing that the composition of glycolipids is species-specific and not influenced by the host's taxonomic position. On the other hand, the profile of betaine lipids may be affected by the host. Additionally, the molecular species of triacylglycerols from freshly isolated symbiotic dinoflagellates were determined for the first time, showing different acyl group compositions based on their position.
Article
Biochemistry & Molecular Biology
Ekaterina V. Ermolenko, Tatyana V. Sikorskaya
Summary: Thermal stress causes significant changes in lipid composition of hard corals, with a decrease in the content of triacylglycerols among storage lipids and a decrease in contents of various glycerophospholipids among structural lipids, especially phosphatidylethanolamine and phosphatidylinositol.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Chemistry, Medicinal
T. Sikorskaya
Summary: The study identified the structures and relative contents of major nonpolar lipid classes in the hydrocoral Millepora platyphylla, providing important data for the development of lipidomics in marine organisms. Additionally, comparisons were made among the nonpolar lipidomes of different coral species, offering insights into coral biochemistry and ecology.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Article
Biochemistry & Molecular Biology
Tatyana Sikorskaya, Ekaterina Ermolenko, Andrey Boroda, Taliya T. Ginanova
Summary: Research has found that during coral bleaching, the host tissues lost a significant part of symbiotic dinoflagellates, possibly through exocytosis. Symbiophagosomes with degenerative dinoflagellates were observed in the early stages of bleaching. At the end of bleaching, the appearance of oxidized phosphatidylethanolamines, indicating damage to the host membranes, and the degradation of the coral tissues were simultaneously observed.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Marine & Freshwater Biology
Tatyana V. Sikorskaya, Ekaterina V. Ermolenko, Kseniya V. Efimova
Summary: Gorgonian corals have complex interactions with microorganisms, and the microorganisms influence the lipidome of the corals. Lipids are likely transported from the microbial community to the coral host, and some lipid molecular species are derived from anaerobic bacteria. Symbiotic corals have higher storage lipids (triacylglycerols) compared to non-symbiotic corals.
Article
Chemistry, Medicinal
Andrey B. Imbs, Ekaterina V. Ermolenko, Valeria P. Grigorchuk, Tatiana V. Sikorskaya, Peter V. Velansky
Summary: Marine invertebrates, which make up over 90% of marine animal species, rely on lipids for cell membranes and energy reserves. The lipid composition directly impacts the nutritional value of commercial invertebrates. Despite detailed studies on lipid classes and fatty acids, data on lipidomes are limited, with only a few species investigated. The application of lipidomics in ecology, physiology, and nutritional value studies of marine invertebrates shows potential for further exploration.
Article
Chemistry, Medicinal
Tatyana Sikorskaya, Ekaterina Ermolenko, Kseniya Efimova, Ly T. P. Dang
Summary: The study analyzed and compared the thylakoid lipidomes of three different coral holobionts, showing distinctive features in lipid profiles associated with thermal tolerance in some symbionts. Understanding the lipid composition of symbionts may help predict coral adaptation in changing environments.
Article
Marine & Freshwater Biology
Tatyana Sikorskaya, Ekaterina Ermolenko, Andrey Boroda
Summary: Studying the bleaching and recovery processes in octocorals is crucial for predicting reef responses to climate change. Octocoral Sinularia heterospiculata can restore its symbiont population after heat stress, but the photosynthetic activity of the symbionts is reduced.
MARINE AND FRESHWATER BEHAVIOUR AND PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Ekaterina Ermolenko, Tatyana Sikorskaya, Valeria P. Grigorchuk
Summary: This study found that the diet of sea cucumbers, whether they are wild or cultured, can significantly influence the nutritional properties of the product, particularly the molecular species profile of phospholipids.
Review
Chemistry, Medicinal
Tatyana V. V. Sikorskaya
Summary: This study summarizes the molecular species of plasma membrane lipids of coral hosts and their dinoflagellates, including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, ceramideaminoethylphosphonate, and diacylglyceryl-3-O-carboxyhydroxymethylcholine. The features of lipids are influenced by the type of coral species and the presence of an exoskeleton. The thermosensitivity of dinoflagellates affects the profiles of phosphatidylglycerol and glycolipid species, which can be changed by the coral host. Microbes such as bacteria and fungi can also contribute to the alkyl and acyl chains of coral membrane lipids. The lipidomics approach provides valuable insights into the biochemistry and ecology of corals.
Article
Food Science & Technology
Ekaterina V. Ermolenko, Tatyana V. Sikorskaya, Valeria P. Grigorchuk
Summary: In this study, the lipid compositions of the hepatopancreas and muscles of the Japanese mitten crab and the red king crab were analyzed using supercritical fluid and high-performance liquid chromatography coupled with high-resolution mass spectrometry. The results showed that triacylglycerols were the main lipids in the crab hepatopancreas, while they were found in trace amounts in muscle. The lipid compositions of the two crab species differed, and both were found to contain high levels of polyunsaturated fatty acids.
