Benchmark Glycan Profile of Therapeutic Monoclonal Antibodies Produced by Mammalian Cell Expression Systems

Why is there no biosimilar of Erbitux®?

(2023) Emmanuel Douez et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy

(2023) Falk Nimmerjahn et al.   NATURE IMMUNOLOGY

Progress toward rapid, at-line N-glycosylation detection and control for recombinant protein expression

(2022) Leran Mao et al.   CURRENT OPINION IN BIOTECHNOLOGY

Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis

(2021) Bastiaan L. Duivelshof et al.   Pharmaceutics

The Formidable Challenge of Controlling High Mannose-Type N-Glycans in Therapeutic mAbs

(2020) Renato Mastrangeli et al.   TRENDS IN BIOTECHNOLOGY

Therapeutic Fc‐fusion proteins: Current analytical strategies

(2020) Bastiaan L. Duivelshof et al.   JOURNAL OF SEPARATION SCIENCE

NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

(2019) Maria Lorna A. De Leoz et al.   MOLECULAR & CELLULAR PROTEOMICS

Analytical comparability study of recombinant monoclonal antibody therapeutics

(2018) Alexandre Ambrogelly et al.   mAbs

Impact of cell culture media additives on IgG glycosylation produced in CHO cells

(2018) Janike Ehret et al.   BIOTECHNOLOGY AND BIOENGINEERING

Glycan characterization of the NIST RM monoclonal antibody using a total analytical solution: From sample preparation to data analysis

(2017) Mark Hilliard et al.   mAbs

Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

(2017) Yusuke Mimura et al.   Protein & Cell

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

(2017) Benjamin Peschke et al.   Frontiers in Immunology

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies

(2016) Sha Sha et al.   TRENDS IN BIOTECHNOLOGY

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

Glycan analysis of therapeutic glycoproteins

(2015) Lei Zhang et al.   mAbs

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

(2015) Jinghua Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Role of Antibody N-Glycosylation in Receptor Interactions

(2015) Ganesh P. Subedi et al.   STRUCTURE

N- and O-Glycosylation Analysis of Etanercept Using Liquid Chromatography and Quadrupole Time-of-Flight Mass Spectrometry Equipped with Electron-Transfer Dissociation Functionality

(2013) Stephane Houel et al.   ANALYTICAL CHEMISTRY

Expression of Recombinant Antibodies

(2013) André Frenzel et al.   Frontiers in Immunology

Analysis of Nonhuman N-Glycans as the Minor Constituents in Recombinant Monoclonal Antibody Pharmaceuticals

(2012) Eiki Maeda et al.   ANALYTICAL CHEMISTRY

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Increased serum clearance of oligomannose species present on a human IgG1 molecule

(2012) Leslie Alessandri et al.   mAbs

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

(2011) A. M. Goetze et al.   GLYCOBIOLOGY

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

(2010) Darius Ghaderi et al.   NATURE BIOTECHNOLOGY