Stability and compatibility of intraperitoneal antimicrobials in peritoneal dialysate solutions

To optimise antimicrobial administration in patients with peritoneal dialysis (PD)-related peritonitis, healthcare providers need literature-based information to develop patient-centred pharmacotherapeutic plans. Traditional PD solutions promote osmosis using dextrose or icodextrin with a lactate buffer. Newer PD solutions have modified the osmotic vehicle and buffer. Knowledge of antimicrobial compatibility and stability with newer PD solutions will assist with determining the route of antimicrobial administration as compatible and stable solutions could be delivered directly to the peritoneum using intraperitoneal administration. This review updates the compatibility and stability of antimicrobial additives in newer PD solutions for PD-related peritonitis.

Automated summary

In order to optimize the use of antimicrobial drugs in patients with PD-related peritonitis, healthcare providers need to rely on literature-based information to develop patient-centered pharmacotherapeutic plans. Knowing the compatibility and stability of antimicrobial additives in newer PD solutions can help determine the route of antimicrobial administration, as compatible and stable solutions can be directly delivered to the peritoneum via intraperitoneal administration. This review provides an update on the compatibility and stability of antimicrobial additives in newer PD solutions for the treatment of PD-related peritonitis.