Article
Medical Laboratory Technology
Kun-Lin Wu, Che-Yi Chou, Hui-Yin Chang, Chih-Hsun Wu, An-Lun Li, Chien-Lung Chen, Jen-Chieh Tsai, Yi-Fan Chen, Chiung-Tong Chen, Chin-Chung Tseng, Jin-Bor Chen, I-Kuan Wang, Yu-Juei Hsu, Shih-Hua Lin, Chiu-Ching Huang, Nianhan Ma
Summary: This study developed a novel noninvasive miRNA test for diagnosing EPS. By screening miRNA profiles and combining clinical characteristics, machine learning models were able to accurately predict the occurrence of EPS.
CLINICA CHIMICA ACTA
(2022)
Article
Transplantation
Mitsuhiro Tawada, Yasuhiko Ito, Masataka Banshodani, Masahiro Yamashita, Sadanori Shintaku, Ting Sun, Yasuhiro Suzuki, Hiroshi Kinashi, Yoko Kubo, Masahiko Ando, Makoto Yamaguchi, Takayuki Katsuno, Masashi Mizuno, Hideki Kawanishi
Summary: The study found that patients in the conventional PD solution group had less angiogenesis but more severe vasculopathy, while those in the pH-neutral solution group had milder vasculopathy. The L/V ratio was significantly associated with the relapse rate of EPS.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Kanako Watanabe-Kusunoki, Yoshihiro Kusunoki, Junichi Goto, Kazutaka Kukita
Summary: A case of advanced liver cirrhosis with end-stage renal disease (ESRD) developed encapsulating peritoneal sclerosis (EPS) after 4 years of peritoneal dialysis (PD), and was successfully recovered by surgery.
Article
Urology & Nephrology
Miho Murashima, Takayuki Hamano, Masanori Abe, Ikuto Masakane
Summary: This study found that the combination therapy of PD and once-weekly hemodialysis is associated with lower infection-related mortality but not with a lower incidence of EPS in the short term. Patients on combination therapy had a decreasing D/P Cr ratio over time, while those on PD alone had an increasing ratio.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Shingai Pepereke, Ankur D. Shah, Edwina A. Brown
Summary: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome characterized by the formation of fibrous encapsulation around the abdominal organs, leading to increased morbidity and mortality. While most patients undergoing peritoneal dialysis (PD) will not develop EPS, risk factors include duration of PD, peritonitis, and discontinuation of PD. Due to its rarity, knowledge of EPS is mostly based on case series and registries, and treatment methods are extrapolated from low-quality evidence. Malnutrition plays a significant role in mortality, emphasizing the importance of nutritional support in management.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Review
Pediatrics
Videha Sharma, Zia Moinuddin, Angela Summers, Mohan Shenoy, Nicholas Plant, Semir Vranic, Agnieszka Prytula, Zlatan Zvizdic, Vasiliki Karava, Nikoleta Printza, John Vlot, David van Dellen, Titus Augustine
Summary: This study retrospectively analyzed all paediatric patients with EPS treated at the Manchester Centre for Transplantation, demonstrating 100% survival and parenteral feed independence following EPS surgery. Post-operative morbidity was common, but with individualized decision-making and interventions, patients made full recoveries.
PEDIATRIC NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Kensei Taguchi, Yuta Mitsuishi, Sakuya Ito, Tomofumi Moriyama, Kei Fukami
Summary: Glucocorticoids may mask peritoneal inflammation in patients undergoing peritoneal dialysis, leading to the development of encapsulating peritoneal sclerosis.
Article
Multidisciplinary Sciences
Seishi Aihara, Shunsuke Yamada, Shumei Matsueda, Akinori Nagashima, Kumiko Torisu, Takanari Kitazono, Toshiaki Nakano
Summary: Peritoneal calcification is a prominent characteristic of the later stage of encapsulating peritoneal sclerosis in patients on long-term peritoneal dialysis. This study found that calcifying medium accelerates peritoneal cell calcification, which can be prevented by magnesium supplementation.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
So-Jeong Nam, Sun-Hye Song, Seung-Hyun Lee, So-Young Jeung, Jae Gon Ah, Su-Hyung Lee, Min-Ok Ryu
Summary: A 13-year-old neutered male Korean short-hair cat presented with symptoms of anorexia, lethargy, and severe abdominal distension. After a series of tests, it was diagnosed with sclerosing peritoneal carcinomatosis, a rare condition characterized by peritoneal thickening, fat stranding, and calcification.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Oncology
Susumu Hama, Takayuki Nishi, Eitaro Isono, Shoko Itakura, Yutaka Yoshikawa, Akinori Nishimoto, Satoko Suzuki, Naoko Kirimura, Hiroaki Todo, Kentaro Kogure
Summary: Intraperitoneal administration of tocopheryl succinate nanoparticles can effectively prevent peritoneal dissemination of colon cancer and has anticancer effects. These nanoparticles can stably exist in the body and act by improving the intraperitoneal environment and inhibiting cancer cell proliferation.
Article
Urology & Nephrology
Takuya Maeda, Hiroaki Io, Kazuaki Hara, Junichiro Nakata, Masanori Ishizaka, Yuki Shimizu, Yuka Shirotani, Haruna Fukuzaki, Yusuke Suzuki
Summary: This study examined the laparoscopic findings and postoperative complications of patients undergoing peritoneal dialysis catheter removal. The results showed that 16% of cases had adhesion between the catheter and intraperitoneal organs. The study suggests that laparoscopy is an effective tool for detecting and ensuring patient safety.
Article
Infectious Diseases
Valentin al Jalali, Peter Matzneller, Anh Duc Pham, Wisse van Os, Michael Woelfl-Duchek, Maria Sanz-Codina, Andreas Vychytil, Birgit Reiter, Thomas Stimp, Markus Zeitlinger
Summary: This study investigated the pharmacokinetics of CAZ/AVI in patients undergoing APD and found similar PK profiles of the drug in plasma and peritoneal dialysate, indicating the suitability of a fixed-dose combination. Monte Carlo simulations showed that even a low dose of CAZ/AVI achieved a high probability of target attainment for treating infections in APD patients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Editorial Material
Urology & Nephrology
Ana Carina Ferreira
Summary: High-quality and goal-directed PD prescription is important for all PD patients. Prioritizing patients' goals, such as assessing volume and nutritional status, anemia and mineral and bone management, or small-solute removal, is crucial for their quality of life. To optimize small solute removal, increasing concentration gradient difference or volume can be done depending on membrane characteristics, while tailoring intraperitoneal volume through measuring intraperitoneal pressure is necessary to avoid PD-associated mechanical complications.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Xinqiu Li, Tiantian Ma, Jiayu Hao, Di Song, Hongyan Wang, Tianjiao Liu, Yaling Zhang, Nanzha Abi, Xiao Xu, Manze Zhang, Weiqi Sun, Xin Li, Jie Dong
Summary: In this study, two new equations were developed to accurately estimate intraperitoneal pressure (IPP) in peritoneal dialysis (PD) patients. Waist circumference and height from the decubitus plane to mid-axillary line were used to predict IPP values. The newly derived equations showed smaller biases, better precision, and greater accuracy compared to existing equations.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Hematology
Yaxuan Fang, Xin Chen, Ke Zhong, Qingying Ni, Zhenyang He, Yanheng Qiao, Yanru Zhao, Jie Li, Hongtao Yang, Bo Yang
Summary: Encapsulating peritoneal sclerosis (EPS) is a rare and harmful complication that can lead to destructive outcomes. Matrix metalloproteinase-2 (MMP-2), as a protease, plays a crucial role in the progression of EPS by reducing constituents of the extracellular matrix. As a new biomarker, MMP-2 may enhance the detection rate of EPS patients in clinical practice. This review summarizes the recent studies on MMP-2 in different etiologies, assesses its application value, and highlights future directions.
BLOOD PURIFICATION
(2023)