Oral immunotherapy as a curative treatment for food‐allergic preschool children: Current evidence and potential underlying mechanisms

Food Allergen Immunotherapy in Preschool Children: Do We Have the Evidence?

(2023) Paxton Loke et al.   Journal of Allergy and Clinical Immunology-In Practice

Real-World Safety Analysis of Preschool Tree Nut Oral Immunotherapy

(2023) Stephanie C. Erdle et al.   Journal of Allergy and Clinical Immunology-In Practice

Allergen immunotherapy and/or biologicals for IgE‐mediated food allergy: A systematic review and meta‐analysis

(2022) Debra de Silva et al.   ALLERGY

Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study

(2022) Stacie M Jones et al.   LANCET

Remission of peanut allergy is associated with rewiring of allergen‐driven T helper 2‐related gene networks

(2022) Sarah E. Ashley et al.   ALLERGY

Probiotic peanut oral immunotherapy versus oral immunotherapy and placebo in children with peanut allergy in Australia (PPOIT-003): a multicentre, randomised, phase 2b trial

(2022) Paxton Loke et al.   Lancet Child & Adolescent Health

Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health

(2021) Eleanor C. Semmes et al.   Frontiers in Immunology

Antigen-Presenting Cells in Food Tolerance and Allergy

(2021) Elise G. Liu et al.   Frontiers in Immunology

Evolution of Epitope-specific IgE and IgG4 Antibodies in Children Enrolled in the LEAP Trial

(2021) Mayte Suarez-Farinas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T Cell Subsets During Early Life and Their Implication in the Treatment of Childhood Acute Lymphoblastic Leukemia

(2021) Shanie Saghafian-Hedengren et al.   Frontiers in Immunology

Peanut oral immunotherapy in a pediatric allergy clinic: patient factors associated with clinical outcomes

(2021) Katharine M. Guarnieri et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Understanding protein digestion in infants and the elderly: Current in vitro digestion models

(2021) Seonmin Lee et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Improvement of meat protein digestibility in infants and the elderly

(2021) Seonmin Lee et al.   FOOD CHEMISTRY

Rewiring of gene networks underlying mite allergen‐induced CD4+Th‐cell responses during immunotherapy

(2020) Anya C. Jones et al.   ALLERGY

Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?

(2020) Helen A. Brough et al.   ALLERGY

Prenatal development of human immunity

(2020) Jong-Eun Park et al.   SCIENCE

As soon as possible in IgE-cow’s milk allergy immunotherapy

(2020) Javier Boné Calvo et al.   EUROPEAN JOURNAL OF PEDIATRICS

Consensus report from the Food Allergy Research & Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit

(2020) Amber N. Pepper et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early epitope-specific IgE antibodies are predictive of childhood peanut allergy

(2020) Maria Suprun et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

(2020) Björn Weström et al.   Frontiers in Immunology

Five-year follow-up of early intervention peanut oral immunotherapy

(2020) Lauren Herlihy et al.   Journal of Allergy and Clinical Immunology-In Practice

Randomized trial of early infant formula introduction to prevent cow’s milk allergy

(2020) Tetsuhiro Sakihara et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T cell Tolerance in Early Life

(2020) Lijun Yang et al.   Frontiers in Immunology

First Real-World Effectiveness Analysis of Preschool Peanut Oral Immunotherapy

(2020) Lianne Soller et al.   Journal of Allergy and Clinical Immunology-In Practice

Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?

(2019) Nikos E. Papaioannou et al.   Frontiers in Immunology

Mechanisms that define transient versus persistent food allergy

(2019) M. Cecilia Berin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early oral immunotherapy in infants with cow’s milk protein allergy

(2019) Irene Berti et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy

(2019) Sarita U. Patil et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study

(2019) R Sharon Chinthrajah et al.   LANCET

IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy

(2019) Stephen C. Dreskin et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

The Natural Course of Immediate-Type Cow’s Milk and Egg Allergies in Children

(2019) Minji Kim et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

(2019) Michael R. Perkin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE

(2019) Mindy Tsai et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Goblet cell associated antigen passages support the induction and maintenance of oral tolerance

(2019) Devesha H. Kulkarni et al.   Mucosal Immunology

Treatment for food allergy

(2018) A. Wesley Burks et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life

(2018) Peter S. Hsu et al.   JOURNAL OF IMMUNOLOGY

Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts

(2018) Thanh D Dang et al.   ALLERGY

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles

(2018) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective

(2017) Brian P. Vickery et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial

(2017) Osamu Natsume et al.   LANCET

Protein Digestion of Baby Foods: Study Approaches and Implications for Infant Health

(2017) Junai Gan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2

(2017) Naomi McGovern et al.   NATURE

Oral Food Desensitization in Children With IgE-Mediated Cow's Milk Allergy: Immunological Changes Underlying Desensitization

(2017) Laura Perezábad et al.   Allergy Asthma & Immunology Research

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

The Natural History of Food Allergy

(2016) Jessica Savage et al.   Journal of Allergy and Clinical Immunology-In Practice

Food Allergy

(2015) Jessica Savage et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues

(2015) Joseph J C Thome et al.   NATURE MEDICINE

Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

(2015) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of the immune system in humans from infancy to old age

(2015) A. Katharina Simon et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immune responses in neonates

(2014) Saleem Basha et al.   Expert Review of Clinical Immunology

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)

(2014) Aleena Syed et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy

(2013) Brian P. Vickery et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intestinal CD103+ Dendritic Cells Are Key Players in the Innate Immune Control of Cryptosporidium parvum Infection in Neonatal Mice

(2013) Louis Lantier et al.   PLoS Pathogens

Ontogeny of oral drug absorption processes in children

(2012) Miriam G Mooij et al.   Expert Opinion on Drug Metabolism & Toxicology

Update on risk factors for food allergy

(2012) Gideon Lack   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The natural history of persistent peanut allergy

(2011) Dara L. Neuman-Sunshine et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy

(2011) A. Martorell et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Reference values for B cell subpopulations from infancy to adulthood

(2010) H. Morbach et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy

(2010) Scott H. Sicherer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Comparative resistance of food proteins to adult and infant in vitro digestion models

(2009) Didier Dupont et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Early clinical predictors of remission of peanut allergy in children

(2008) Marco H.K. Ho et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

FOXP3 Promoter Demethylation Reveals the Committed Treg Population in Humans

(2008) Peter C. J. Janson et al.   PLoS One