Review
Medical Laboratory Technology
Abdul Waheed Khan
Summary: Only a fraction of the transcriptome is translated into proteins, with the rest classified as non coding RNA, which plays crucial roles in gene regulation. MicroRNAs, as a type of post-transcriptional regulator, have diverse functions in both the nucleus and cytoplasm.
TRANSLATIONAL RESEARCH
(2021)
Article
Hematology
Pierre R. Moreau, Vanesa Tomas Bosch, Maria Bouvy-Liivrand, Kadri Ounap, Tiit Ord, Heidi H. Pulkkinen, Petri Polonen, Merja Heinaniemi, Seppo Yla-Herttuala, Johanna P. Laakkonen, Suvi Linna-Kuosmanen, Minna U. Kaikkonen
Summary: This study aimed to characterize microRNA-related regulatory mechanisms in the aorta during atherosclerosis. The research analyzed miRNA expression changes in different cell types under proatherogenic stimuli and found common miRNA species dominating in all cell types. The study identified potential mechanisms by which miRNAs affect atherogenesis in a cell-type-specific manner.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Yu-Xiang Yan, Huan-Bo Xiao, Jie Zhang, Shuo Wang, Jing Dong, Li-Juan Wu
Summary: This study found an association between miR-144 SNP rs9279 and increased risk of T2D, with carriers of the GG genotype showing significantly upregulated expression of miRNAs and cortisol. The SNP may contribute to the development of T2D by altering regulation of the stress response.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Review
Biochemistry & Molecular Biology
Michal Vrablik, Dana Dlouha, Veronika Todorovova, Denes Stefler, Jaroslav A. Hubacek
Summary: Despite advances in molecular genetics and new tools for identifying new genes and variants related to cardiovascular disease (CVD), there is still some ambiguity in using genetic risk scores for predicting CVD risk. Future research should focus on regulatory molecules and epigenetic changes to further understand genetic factors contributing to CVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
J. Lucas McKay, Jonathan Nye, Felicia C. Goldstein, Barbara Sommerfeld, Yoland Smith, David Weinshenker, Stewart A. Factor
Summary: This study investigated the relationship between noradrenergic systems and freezing of gait in Parkinson's disease (PD). The findings suggest that the binding density of norepinephrine transporter is associated with freezing of gait. This has implications for the classification and treatment of freezing of gait.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Plant Sciences
Meng-Qi Zhang, Ke-Xin Sun, Xu Guo, Ying-Ying Chen, Cai-Yun Feng, Jia-Shu Chen, Joao C. M. Barreira, Miguel A. Prieto, Jin-Yue Sun, Jian-Dong Zhang, Ning-Yang Li, Chao Liu
Summary: This study aimed to investigate the uric acid-lowering activity and mechanism of Astragali Radix (AR) and its representative compounds. The results showed that AR could reduce serum uric acid levels and alleviate acute hyperuricemia by regulating uric acid transporters and promoting uric acid excretion. This study provides experimental and clinical basis for the treatment of hyperuricemia with AR.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fei Yu, Fen Liu, Xiao-Mei Li, Qian Zhao, Jun-Yi Luo, Jin-Yu Zhang, Yi-Ning Yang
Summary: In this study, the association between GLUT4 genetic polymorphisms and coronary heart disease (CHD) was explored in the Han and Uygur Chinese populations in Xinjiang, China. The results showed that rs5418 GLUT4 gene variants were associated with CHD in the Uygur population.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Medicine, General & Internal
Olga Martinez-Arroyo, Ana Ortega, Ana Flores-Chova, Belen Sanchez-Garcia, Ana B. Garcia-Garcia, Felipe J. Chaves, Juan C. Martin-Escudero, Maria Jose Forner, Josep Redon, Raquel Cortes
Summary: Elevated plasma microRNA levels, particularly miR-126-3p, are associated with albuminuria in hypertensive patients, and may serve as prognostic markers for cardiovascular events. Further studies are needed to assess the potential role of miR-126-3p in evaluating endothelial dysfunction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Neurosciences
Sophia Armand, Brice Ozenne, Nanna Svart, Vibe G. Frokjaer, Gitte M. Knudsen, Patrick M. Fisher, Dea S. Stenbaek
Summary: Cognitive affective biases refer to the preference for processing negative or positive information. This study investigated the association between 5-HTT levels, measured using positron emission tomography, and affective biases in healthy individuals. The findings suggest that higher 5-HTT levels are associated with a more negative bias.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Ming Li, Yang Li, Yue Lu, Jianhui Li, Xuhang Lu, Yue Ren, Tianlei Wen, Yaojie Wang, Shenghai Chang, Xing Zhang, Xue Yang, Yuequan Shen
Summary: This study presents the cryo-EM structures of human Mrs2, revealing its symmetrical pentameric assembly and the mechanism of Mg2+ permeation. The findings provide important insights into the channel assembly and Mg2+ permeation of Mrs2.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Zheng Cheng, Yonghong Zhang, Yang Zhuo, Jie Fan, Ying Xu, Mengmeng Li, Hao Chen, Li Zhou
Summary: This study found that the rs2327433 site in lncRNA TARID was associated with the risk of coronary artery disease (CAD) and the severity of the disease in the Chinese Han population. Further analysis showed that the rs2327433 site may affect the expression of the atherosclerosis-related transcription factor TCF21 regulated by lncRNA TARID. The study revealed a new mechanism of lncRNA-mediated cell proliferation.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Genetics & Heredity
Akiko Suzuki, Hiroki Yoshioka, Teng Liu, Aania Gull, Naina Singh, Thanh Le, Zhongming Zhao, Junichi Iwata
Summary: This study reveals the regulatory network of genes and microRNAs (miRNAs) related to amelogenesis imperfecta. miR-16-5p and miR-27b-3p were identified as potential pathogenic miRNAs, as they significantly inhibited ameloblast differentiation by regulating mAIGenes.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Xiang-Rui Qiao, Tao Zheng, Yifei Xie, Xinyi Yao, Zuyi Yuan, Yue Wu, Dong Zhou, Tao Chen
Summary: Polymorphisms in miR-146a and miR-34b are associated with the development and prognosis of ACS. The rs2910164 variant of miR-146a is closely related to ACS risk and may activate the NF-kappa B inflammatory pathway through oxidized miR-146a mispairing with IKBA 3'UTR.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Eugenia Annunzi, Loreta Cannito, Fabio Bellia, Francesca Mercante, Matteo Vismara, Beatrice Benatti, Alberto Di Domenico, Riccardo Palumbo, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addario
Summary: This study investigated the epigenetic and genetic regulation of the oxytocin receptor, dopamine transporter, and serotonin transporter genes in relation to Internet addiction. The results showed significant changes in DNA methylation levels and their correlation with psychometric properties. These findings contribute to our understanding of the neurobiology of Internet addiction and offer potential biological predictors for early diagnosis and treatment.
SCIENTIFIC REPORTS
(2023)
Article
Rehabilitation
Clara C. Zwack, Rachael McDonald, Ainura Tursunalieva, Shradha Vasan, Gavin W. Lambert, Elisabeth A. Lambert
Summary: The study showed that adults with intellectual disabilities experience higher levels of perceived stress compared to those without disabilities, likely due to unique stressors they face. Stress is strongly associated with social isolation, obesity in females with mild intellectual disabilities, and arterial stiffness.
DISABILITY AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Jordan H. Lai, Stella M. Gwini, Gang Chen, Katrina M. Long, Grant Russell, Markus P. Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori, Martin Wolley, Christopher M. Reid, Jun Yang
Summary: This study evaluated the willingness of the Australian general public to undergo testing for secondary causes of hypertension and identified some enablers and barriers from the patients' perspective. The results showed that the majority of patients were willing to be tested, and education about the risks and testing process may help overcome some barriers.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Urology & Nephrology
Joanne A. O'Donnell, Tenghao Zheng, Guillaume Meric, Francine Z. Marques
Summary: A large body of evidence has shown that the gut microbiome plays a role in regulating blood pressure through various mechanisms, including changes in gene pathways and the production of beneficial or detrimental metabolites. Dysbiosis in the gut microbiome can result in inflammation and disruption of the intestinal barrier, activating mechanisms associated with blood pressure regulation. Challenges in gut microbiome research include minimizing confounding factors and establishing causality, but new approaches such as clinical trials and computational methods offer potential for leveraging the microbiome to lower blood pressure.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Anesthesiology
J. M. Nolde, M. P. Schlaich, D. I. Sessler, A. Mian, T. B. Corcoran, C. K. Chow, M. T. V. Chan, F. K. Borges, M. H. McGillion, P. S. Myles, N. L. Mills, P. J. Devereaux, G. S. Hillis
Summary: This study aimed to determine the discrimination, calibration, accuracy, sensitivity, and specificity of single-layer and multiple-layer neural networks for predicting myocardial injury and death within 30 days after surgery. The results showed that the multiple-layer model had higher accuracy in predicting myocardial injury and death, with accuracies of 70% and 89%, respectively.
Editorial Material
Cardiac & Cardiovascular Systems
Chudan Xu, Francine Z. Marques
CARDIOVASCULAR RESEARCH
(2023)
Review
Endocrinology & Metabolism
Louise M. Woodhams, Leanne Chalmers, Tin Fei Sim, Bu B. Yeap, Markus P. Schlaich, Carl Schultz, Graham S. Hillis
Summary: Recent studies have shown the need for innovative treatment options for end-stage diabetic kidney disease in many people with type 2 diabetes. In this updated systematic review and meta-analysis, the combination of SGLT2 inhibitors with ACE inhibitors and/or ARBs was found to significantly reduce albuminuria, glycated hemoglobin, and systolic blood pressure in people with type 2 diabetes compared to standard care alone.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2023)
Article
Peripheral Vascular Disease
Thomas Beaney, Wei P. Wang, Markus E. Schlaich, Aletta S. Schutte, George Stergiou, Luis Alcocer, Jafar Alsaid, Alejandro Bimbo Diaz, Rafael Hernandez-Hernandez, Mohammad Ishaq, Jacek Jozwiak, Nadia Khan, Gaia Kiru, Harsha McCardle, Augustine Nonso Odili, Wook Bum A. Pyun, Cesar Romero, Jiguang R. Wang, Neil Poulter
Summary: The MMM 2021 assessed the global burden of hypertension during the COVID-19 pandemic and found a high proportion of untreated or inadequately treated patients, indicating the need for improved global blood pressure screening and management.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Isabella Tan, Sonali R. Gnanenthiran, Justine Chan, Konstantinos G. Kyriakoulis, Markus P. Schlaich, Anthony Rodgers, George S. Stergiou, Aletta E. Schutte
Summary: This study investigated the accuracy of a commercially available cuffless wearable blood pressure device in tracking blood pressure changes. The results showed that compared to conventional monitoring methods, the device reported higher values for 24-hour and nighttime systolic and diastolic blood pressure, and it was unable to accurately track medication-induced blood pressure changes.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Sonali R. Gnanenthiran, Isabella Tan, Emily R. Atkins, Alberto Avolio, Belinda Bennett, Niamh Chapman, Clara K. Chow, Ruth Freed, Danijela Gnjidic, Charlotte Hespe, Baldeep Kaur, Huei Ming Liu, Anushka Patel, David Peiris, Christopher M. Reid, Markus Schlaich, James E. Sharman, George S. Stergiou, Tim Usherwood, Christopher Gianacas, Anthony Rodgers, Aletta E. Schutte
Summary: This study aims to investigate the effectiveness, safety, acceptability, and cost-effectiveness of a wearable blood pressure monitor-based care strategy in reducing clinic blood pressure. The study will enroll 600 adults with high blood pressure, comparing the intervention group using wearable-based remote care with the control group receiving usual care. The primary outcome is the difference in change in clinic systolic blood pressure between the two groups from baseline to 12 months.
AMERICAN HEART JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Omar Azzam, Sayeh Heidari Nejad, Revathy Carnagarin, Janis M. Nolde, Marcio Galindo-Kiuchi, Markus P. Schlaich
Summary: Resistant hypertension is associated with high cardiovascular risk and current guideline-recommended therapy is not sufficient. Recent landmark trials have shown promising results for novel compounds targeting unaddressed pathophysiologic pathways and catheter-based renal denervation as an effective adjunct therapeutic approach.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Janis M. Nolde, Emily Atkins, Simone Marschner, Graham S. Hillis, John Chalmers, Laurent Billot, Mark R. Nelson, Christopher M. Reid, Peter Hay, Michael Burke, Shirley Jansen, Tim Usherwood, Anthony Rodgers, Clara K. Chow, Markus P. Schlaich
Review
Peripheral Vascular Disease
Sayeh Heidari Nejad, Omar Azzam, Markus P. Schlaich
Summary: Resistant hypertension is associated with increased cardiovascular and renal events, and endothelin antagonists could be a potential alternative fourth-line therapy. Recent research on the dual endothelin antagonist Aprocitentan has shown its safety and efficacy in lowering blood pressure.
CURRENT HYPERTENSION REPORTS
(2023)
Letter
Peripheral Vascular Disease
Aletta E. Schutte, Isabella Tan, Sonali R. Gnanenthiran, Justine Chan, Konstantinos G. Kyriakoulis, Markus P. Schlaich, Anthony Rodgers, George S. Stergiou
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
David E. Kandzari, Raymond R. Townsend, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart Pocock, Konstantinos Tsiou, Dimitrios Konstantinidis, James Choi, Cara East, Lucas Lauder, Debbie L. Cohen, Taisei Kobayashi, Axel Schmid, David P. Lee, Adrian Ma, Joachim Weil, Tolga Agdirlioglu, Markus P. Schlaich, Sharad Shetty, Chandan M. Devireddy, Janice Lea, Jiro Aoki, Andrew S. P. Sharp, Richard Anderson, Martin Fahy, Vanessa DeBruin, Sandeep Brar, Michael Boehm
Summary: This trial evaluated the safety and efficacy of renal denervation (RDN) in patients with uncontrolled hypertension who were also taking antihypertensive medications. The study found no significant difference between the RDN group and the sham control group in terms of the primary efficacy endpoint. However, multiple secondary endpoint analyses favored RDN over the sham control.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Mansi Patil, Radhika Prashant Hedaoo, Rohan Pravinbhai Shah, Syed Mohammad Tauseef, Roy Rillera Marzo, Siew Mooi Ching, Gavin Lambert
Summary: The burden of hypertension has been increasing, and besides the risk of stroke and cardiovascular disease, it also affects the quality of life (QoL) of individuals. This study aimed to assess the QoL of hypertensive men undergoing treatment in India. The results showed that patients with uncontrolled hypertension had significantly poorer QoL compared to those with controlled blood pressure.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)