Practical Synthetic Method for Amino Acid-Derived Diazoketones Shelf-Stable Reagents for Organic Synthesis

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions

(2020) Jillian W. Sheeran et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of Oxazinanones: Intramolecular Cyclization of Amino Acid-Derived Diazoketones via Silica-Supported HClO4 Catalysis

(2019) Rafael D. C. Gallo et al.   Frontiers in Chemistry

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

(2019) Andrew R. Bogdan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Reactions of Diazoketones

(2019) Ritu Arora et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Design and Optimization of a Continuous Stirred Tank Reactor Cascade for Membrane-Based Diazomethane Production: Synthesis of α-Chloroketones

(2019) Michaela Wernik et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents

(2019) Sebastian P. Green et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis, crystal structure, catalytic dimerization and S H insertion of new porphyrin diazoketones

(2018) Daniel Carrié et al.   JOURNAL OF MOLECULAR STRUCTURE

α-Arylamino Diazoketones: Diazomethane-Loading Controlled Synthesis, Spectroscopic Investigations, and Structural X-ray Analysis

(2018) Laura Castoldi et al.   JOURNAL OF ORGANIC CHEMISTRY

On-Demand Generation and Consumption of Diazomethane in Multistep Continuous Flow Systems

(2018) Hongwei Yang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Diazocarbonyl derivatives of amino acids: unique chiral building blocks for the synthesis of biologically active compounds

(2018) D P Zarezin et al.   RUSSIAN CHEMICAL REVIEWS

A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU

(2017) H. Lehmann   GREEN CHEMISTRY

Modern Organic Synthesis with α-Diazocarbonyl Compounds

(2015) Alan Ford et al.   CHEMICAL REVIEWS

Heat Management in Microreactors for Fast Exothermic Organic Syntheses—First Design Principles

(2015) Thomas Westermann et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Flow Synthesis of α-Halo Ketones: Essential Building Blocks of Antiretroviral Agents

(2014) Vagner D. Pinho et al.   JOURNAL OF ORGANIC CHEMISTRY

Amino acid chirons: a tool for asymmetric synthesis of heterocycles

(2014) Priyanka Singh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Continuous flow synthesis of β-amino acids from α-amino acids via Arndt–Eistert homologation

(2014) Vagner D. Pinho et al.   RSC Advances

A One-Pot Procedure for the Preparation of N-9-Fluorenylmethyloxycarbonyl-α-amino Diazoketones from α-Amino Acids

(2012) Carlo Siciliano et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Enantiopure Dehydropiperidinones from α-Amino Acids and Alkynes via Azetidin-3-ones

(2012) Naoki Ishida et al.   ORGANIC LETTERS

Continuous In Situ Generation, Separation, and Reaction of Diazomethane in a Dual-Channel Microreactor

(2011) Ram Awatar Maurya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

(2011) Emiliano Rossi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

1-(3-Chloro-4-fluorophenyl)-5-(2-diazoacetyl)-4-phenylpyrrolidin-2-one

(2010) Jayanta Kumar Ray et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

Improved Arndt−Eistert Synthesis of α-Diazoketones Requiring Minimal Diazomethane in the Presence of Calcium Oxide as Acid Scavenger

(2010) Vittorio Pace et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Amino Acid Derived Enaminones via Wolff Rearrangement Using Vinylogous Amides as Carbon Nucleophiles

(2010) Hajime Seki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermal risk assessment and rankings for reaction hazards in process safety

(2009) Qingsheng Wang et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Making diazomethane accessible for R&D and industry: generation and direct conversion in a continuous micro-reactor set-up

(2007) Michael Struempel et al.   GREEN CHEMISTRY