Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester

C(sp3)-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (SNAr)

(2022) Steven M. Wales et al.   ACCOUNTS OF CHEMICAL RESEARCH

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

(2020) Stephane Daffis et al.   HEPATOLOGY

Discovery of GS-9688 (Selgantolimod), as a Potent and Selective Oral Toll-like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B

(2020) Richard L. Mackman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Large-Scale Route to Glecaprevir: Synthesis of the Side Chain and Final Assembly

(2020) David R. Hill et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Therapeutic potential of TLR8 agonist GS‐9688 (selgantolimod) in chronic hepatitis B: re‐modelling of antiviral and regulatory mediators

(2020) Oliver E. Amin et al.   HEPATOLOGY

Stereoselective synthesis of acyclic α,α-disubstituted α-amino acids derivatives from amino acids templates

(2019) Carlos Cativiela et al.   TETRAHEDRON

Recent Advances in Asymmetric Catalytic Methods for the Formation of Acyclic α,α-Disubstituted α-Amino Acids

(2014) Alison E. Metz et al.   JOURNAL OF ORGANIC CHEMISTRY

Update 1 of: Enantioselective Enzymatic Desymmetrizations in Organic Synthesis

(2011) Eduardo García-Urdiales et al.   CHEMICAL REVIEWS

Candida antarctica Lipase B in a Chemoenzymatic Route to Cyclic α-Quaternary α-Amino Acid Enantiomers

(2011) Xiang-Guo Li et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester

(2010) Kevin M. Belyk et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of Enantiopure Fmoc-α-Methylvaline

(2008) Lianhe Shu et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT