Oxidant- and Base-Free, Copper-Catalyzed Difluoromethylation of Haloalkynes

Copper-Catalyzed Synthesis of Difluoromethyl Alkynes from Terminal and Silyl Acetylenes

(2023) Xanath Ispizua-Rodriguez et al.   Journal of Organic Chemistry

Copper-Catalyzed Visible-Light-Induced Allylic Difluoromethylation of Unactivated Alkenes Using Difluoroacetic Acid

(2023) Jinlian Wang et al.   Organic Letters

Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions

(2023) Huanhuan Song et al.   CCS Chemistry

Oxidative addition of an alkyl halide to form a stable Cu(III) product

(2023) Yongrui Luo et al.   SCIENCE

Recent Advances in the Functionalization of Terminal and Internal Alkynes

(2022) Arti Ramani et al.   Asian Journal of Organic Chemistry

[Ph 4 P] + [Cu(CF 2 H) 2 ] − : A Powerful Difluoromethylating Reagent Inspired by Mechanistic Investigation

(2022) Haiwei Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethylation of Alkyl Bromides and Iodides with TMSCF2H

(2021) Haiwei Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Iron‐Catalyzed Fluoroalkylation of Arylborates with Sulfone Reagents: Beyond the Limitation of Reduction Potential

(2021) Zhiqiang Wei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Perfluoroalkylation of Alkynyl Bromides and Terminal Alkynes

(2021) Shilu Fan et al.   ORGANIC LETTERS

Introduction: Click Chemistry

(2021) Neal K. Devaraj et al.   CHEMICAL REVIEWS

Decarbonylative Fluoroalkylation at Palladium(II): From Fundamental Organometallic Studies to Catalysis

(2021) Naish Lalloo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Chemodivergent 1,1-Difunctionalization of Unactivated α-Olefins with Alkynyl Electrophiles and B2pin2

(2020) Yangyang Li et al.   ACS Catalysis

Copper‐Catalyzed Deaminative Difluoromethylation

(2020) Xiaojun Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A General C-H Difluoromethylation Protocol for Carbon Acids Using TMSCF2Br

(2019) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid

(2019) Claudio F. Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?

(2019) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homogeneous and Nanoparticle Gold-Catalyzed Hydrothiocyanation of Haloalkynes

(2019) Xiaojun Zeng et al.   ORGANIC LETTERS

Copper-Catalyzed Decarboxylative Difluoromethylation

(2019) Xiaojun Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Keto-Difluoromethylation of Aromatic Alkenes by Photoredox Catalysis: Step-Economical Synthesis of α-CF2H-Substituted Ketones in Flow

(2019) Yoshiki Nakayama et al.   ACS Catalysis

Copper-Catalyzed, Chloroamide-Directed Benzylic C–H Difluoromethylation

(2019) Xiaojun Zeng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone

(2018) Wenjun Miao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen-Bonding-Assisted Brønsted Acid and Gold Catalysis: Access to Both (E)- and (Z)-1,2-Haloalkenes via Hydrochlorination of Haloalkynes

(2018) Xiaojun Zeng et al.   ACS Catalysis

Palladium-Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature

(2018) Fei Pan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chlorodifluoromethane-triggered formation of difluoromethylated arenes catalysed by palladium

(2017) Zhang Feng et al.   Nature Chemistry

Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides

(2017) Jean-Denys Hamel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes

(2017) James R. Bour et al.   ORGANOMETALLICS

Direct Difluoromethylation of Aryl Halides via Base Metal Catalysis at Room Temperature

(2016) Long Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent

(2016) Hiroki Serizawa et al.   ORGANIC LETTERS

Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent

(2016) Kohsuke Aikawa et al.   ORGANIC LETTERS

Hydrogen Bonding Cluster-Enabled Addition of Sulfonic Acids to Haloalkynes: Access to Both (E)- and (Z)-Alkenyl Sulfonates

(2016) Xiaojun Zeng et al.   ORGANIC LETTERS

Siladifluoromethylation and Difluoromethylation onto C(sp3), C(sp2), and C(sp) Centers Using Ruppert–Prakash Reagent and Fluoroform

(2016) Kohsuke Aikawa et al.   ORGANIC LETTERS

Difluoromethylation of Terminal Alkynes by Fluoroform

(2015) Satoshi Okusu et al.   ORGANIC LETTERS

Copper-mediated oxidative difluoromethylation of terminal alkynes with TMSCF2H

(2015) Sheng-Qing Zhu et al.   Organic Chemistry Frontiers

Haloalkynes: A Powerful and Versatile Building Block in Organic Synthesis

(2014) Wanqing Wu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Sandmeyer Difluoromethylation of (Hetero-)Arenediazonium Salts

(2014) Christian Matheis et al.   ORGANIC LETTERS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Reactions of Difluorocarbene with Organozinc Reagents

(2013) Vitalij V. Levin et al.   ORGANIC LETTERS

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Difluoromethylation of O-, S-, N-, C-Nucleophiles Using Difluoromethyltri(n-butyl)ammonium Chloride as a New Difluorocarbene Source

(2011) Fei Wang et al.   CHINESE JOURNAL OF CHEMISTRY

Palladium-Catalyzed Coupling of Haloalkynes with Allyl Acetate: A Regio- and Stereoselective Synthesis of (Z)-β-Haloenol Acetates

(2011) Xiaoyi Chen et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Tosyl-S-difluoromethyl-S-phenylsulfoximine: A New Difluoromethylation Reagent for S-, N-, and C-Nucleophiles

(2009) Wei Zhang et al.   ORGANIC LETTERS