Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia

(2015) Dibyadeep Datta et al.   BIOLOGICAL PSYCHIATRY

Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse

(2015) Mónica S. Montesinos et al.   NEURON

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain

(2015) Alisa Mo et al.   NEURON

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

(2015) Natasha K. Hussain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

A Presynaptic Role for the Cytomatrix Protein GIT in Synaptic Vesicle Recycling

(2014) Jasmin Podufall et al.   Cell Reports

GIT1 and βPIX Are Essential for GABA A Receptor Synaptic Stability and Inhibitory Neurotransmission

(2014) Katharine R. Smith et al.   Cell Reports

Inhibitory neurons in human cortical circuits: substrate for cognitive dysfunction in schizophrenia

(2013) David A Lewis   CURRENT OPINION IN NEUROBIOLOGY

Dlx1 transcription factor regulates dendritic growth and postsynaptic differentiation through inhibition of neuropilin-2 and PAK3 expression

(2013) Xiaojing Dai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis

(2013)   LANCET

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families

(2013) Andrew E. Timms et al.   JAMA Psychiatry

Exome Sequencing Followed by Large-Scale Genotyping Suggests a Limited Role for Moderately Rare Risk Factors of Strong Effect in Schizophrenia

(2012) Anna C. Need et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanistic Insights into Regulated Cargo Binding by ACAP1 Protein

(2012) Ming Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

(2011) Ger J.A. Ramakers et al.   HUMAN MOLECULAR GENETICS

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice

(2011) Hyejung Won et al.   NATURE MEDICINE

Gene Expression and Genetic Variation Data Implicate PCLO in Bipolar Disorder

(2010) Kwang H. Choi et al.   BIOLOGICAL PSYCHIATRY

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice

(2010) Prashanthi Menon et al.   BRAIN RESEARCH

The Structure of an Arf-ArfGAP Complex Reveals a Ca2+ Regulatory Mechanism

(2010) Shehab A. Ismail et al.   CELL

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

p21-Activated Kinases 1 and 3 Control Brain Size through Coordinating Neuronal Complexity and Synaptic Properties

(2010) W. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Impaired fear response in mice lacking GIT1

(2009) Robert Schmalzigaug et al.   NEUROSCIENCE LETTERS

A novel splice mutation in PAK3 gene underlying mental retardation with neuropsychiatric features

(2008) Imen Rejeb et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

GIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 Motifs

(2008) Ziwei M. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consensus nomenclature for the human ArfGAP domain-containing proteins

(2008) Richard A. Kahn et al.   JOURNAL OF CELL BIOLOGY

Structures of Dimeric GIT1 and Trimeric β-PIX and Implications for GIT–PIX Complex Assembly

(2008) Oliver Schlenker et al.   JOURNAL OF MOLECULAR BIOLOGY

Rare chromosomal deletions and duplications increase risk of schizophrenia

(2008) Jennifer L. Stone et al.   NATURE