Article
Plant Sciences
Akira Akamatsu, Miwa Nagae, Yuka Nishimura, Daniela Romero Montero, Satsuki Ninomiya, Mikiko Kojima, Yumiko Takebayashi, Hitoshi Sakakibara, Masayoshi Kawaguchi, Naoya Takeda
Summary: Research shows that gibberellic acid (GA) inhibits root nodule symbiosis by regulating a negative-feedback system called autoregulation of nodulation (AON). GA signaling induces the expression of the symbiotic transcription factor NODULE INCEPTION (NIN), which activates the AON system to regulate nodule formation.
Article
Plant Sciences
Yan Du, Shanwei Luo, Jian Zhao, Zhuo Feng, Xia Chen, Weibin Ren, Xiao Liu, Zhuanzi Wang, Lixia Yu, Wenjian Li, Ying Qu, Jie Liu, Libin Zhou
Summary: The mutant C416 in Lotus japonicus, derived from heavy-ion beam irradiation, exhibited significantly prolonged flower longevity controlled by a single gene related to ethylene signaling, providing insights into flower senescence mechanism. Transcriptome analysis revealed altered phytohormone regulatory network in C416, indicating potential for improving flower longevity in leguminous plants through heavy-ion beam technology.
Review
Plant Sciences
William Agbemafle, Min May Wong, Diane C. Bassham
Summary: This review summarizes key regulatory mechanisms for modulating autophagy through post-translational modification or transcriptional regulation. Plants activate cellular responses to adapt to changing environmental conditions, one of which is autophagy, where cellular components are delivered to the vacuole for degradation. Autophagy is activated by various conditions, and the pathways controlling its activation are being elucidated. However, there is still much to discover regarding how these factors work together to properly modulate autophagy in response to specific signals.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Chiung-Min Wang, William Harry Yang, Leticia Cardoso, Ninoska Gutierrez, Richard Henry Yang, Wei-Hsiung Yang
Summary: The study demonstrated that FOXP3 regulates ATF3 expression by reducing ATF3 protein levels and inhibiting its promoter activity. Specifically, the phosphorylation mutation on FOXP3 (Y342F) significantly disrupted FOXP3-mediated ATF3 expression regulation. The results suggest that FOXP3 functions as a novel regulator of ATF3, potentially impacting tumor development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Brittany J. Bisnett, Brett M. Condon, Caitlin H. Lamb, George R. Georgiou, Michael Boyce
Summary: COPII, an ancient and essential pathway in eukaryotes, mediates forward trafficking of protein and lipid cargoes from the endoplasmic reticulum. Despite its broad significance, major aspects of COPII trafficking remain incompletely understood. Recent studies have highlighted the role of post-transcriptional mechanisms in regulating the COPII pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Weijuan Zhou, Zhaoji Li, Wentao Wu, Xia Zhao, Enbo Wang, Jian Wang, Xiqiang Song, Ying Zhao
Summary: This study investigates the opening and closing mechanisms of night-blooming and day-blooming waterlily flowers, identifying the involvement of endogenous ABA hormone and cell wall modification pathways as key factors in regulating the flowering process. The findings provide new insights into the regulation of flower opening and closing in Nymphaea lotus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xiaoyun Gong, Elaine Jensen, Simone Bucerius, Martin Parniske
Summary: This study identified a regulatory complex and specific cis- and trans-acting factors that control gene expression in arbuscular mycorrhiza (AM) and nitrogen-fixing root nodule symbiosis (RNS). The CCaMK/Cyclops complex was found to play a crucial role in gene expression during both AM and RNS, and other specificity-conferring factors need to be identified.
Review
Cell Biology
David G. Courtney
Summary: The field of mRNA modifications has been growing steadily in recent years, with a subfield focused on how these modifications affect viral RNA. Various RNA modifications have been found to be present on viral RNA, posing interesting questions about their evolutionary benefit and their role in viral replication research.
Article
Chemistry, Applied
Liping Sun, Jingtian Huo, Jieya Liu, Jiayi Yu, Jialing Zhou, Chongde Sun, Yue Wang, Feng Leng
Summary: Anthocyanins play crucial roles in plant resistance, human health, and fruit coloring, making them highly valued. This review extensively covers the functions, classifications, distributions, biosynthesis, decoration, transportation, transcriptional regulation, DNA methylation, and post-translational regulation of anthocyanins in fruits.
Article
Cell Biology
Amber A. Parnell, Aliza K. De Nobrega, Lisa C. Lyons
Summary: The endogenous circadian clock maintains optimal physiological health through tissue-specific coordination of gene expression and synchronization between metabolic processes. Dysfunction of the circadian clock is associated with various diseases including cancer, diabetes, and mood disorders. Understanding the complexity of circadian regulation is crucial for future therapeutic advancements.
CELLULAR SIGNALLING
(2021)
Article
Agriculture, Dairy & Animal Science
Du Zhang, Shumei Wu, Xinxin Zhang, Shuqiang Ren, Zhonglin Tang, Fei Gao
Summary: This study reveals the coordinated regulatory mechanism of 5mC and m(6)A in porcine prenatal myogenesis and postnatal skeletal muscle growth, and identifies a group of myogenesis-related genes collaboratively regulated by these two modifications.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Yang Li, Shimiao Zhu, Yutong Chen, Qianwang Ma, Duo Kan, Wenyue Yu, Boya Zhang, Xuanrong Chen, Wanqing Wei, Yi Shao, Keruo Wang, Mingpeng Zhang, Shu Deng, Yuanjie Niu, Zhiqun Shang
Summary: Through m(6)A-sequencing of patient cancer tissues, we found that the overall level of m(6)A was upregulated in castration resistance prostate cancer (CRPC) compared to castration sensitive prostate cancer (CSPC). Further analysis revealed enhanced m(6)A modification of HRAS and MEK2 in CRPC. METTL3 was found to activate the ERK pathway to promote ADT resistance, cell proliferation, and invasion. Targeting the METTL3/ERK axis can restore Enzalutamide resistance in vitro and in vivo.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Erigene Bakangura, Philippe Roger, Rafaela S. B. Soares, Mohamed Mellah, Nadine Barroca-Aubry, Anne-Chantal Gouget-Laemmel, Francois Ozanam, Ludovic Costa, Jean-Pierre Baltaze, Emmanuelle Schulz
Summary: This study reports the use of copolymers as valuable supports for heterogeneous catalysts in the field of asymmetric catalysis. The synthesized copolymers showed excellent activity and selectivity in the asymmetric ring opening of cyclohexene oxide and could be recovered and reused multiple times through simple filtration.
Article
Cell Biology
Yuting Xiang, Chuanchuan Zhou, Yanyan Zeng, Qi Guo, Jiana Huang, Taibao Wu, Jiawen Liu, Qiqi Liang, Haitao Zeng, Xiaoyan Liang
Summary: N4-acetylcytidine (ac4C), an epigenetic modification within mRNA, is crucial in regulating mRNA stability and translation efficiency. NAT10 is the enzyme responsible for ac4C production in mammals, and its knockdown delays meiotic maturation in vitro. Identification of TBL3 as a potential ac4C-binding protein suggests its role in downstream cellular activities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Wenxia Si, Bisheng Zhou, Wen Xie, Hui Li, Ke Li, Sisi Li, Wenbing Deng, Pengcheng Shi, Chao Yuan, Tie Ke, Xiang Ren, Xin Tu, Xiaomei Zeng, Britta Weigelt, Brian P. Rubin, Qiuyun Chen, Chengqi Xu, Qing Kenneth Wang
Summary: AGGF1 acts as a tumor suppressor by regulating p53 inside tumor cells, inhibiting MDM2 function, and influencing various properties of p53 and transcription of related genes, thereby affecting the growth and apoptosis of tumor cells.
Article
Biochemistry & Molecular Biology
Qian Jia, Wei Xie
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Jie Tu, Ran Chen, Ye Yang, Weiguo Cao, Wei Xie
NATURE CHEMICAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Zhang Zhang, Li-Qian Chen, Yu-Li Zhao, Cai-Guang Yang, Ian A. Roundtree, Zijie Zhang, Jian Ren, Wei Xie, Chuan He, Guan-Zheng Luo
Article
Biochemistry & Molecular Biology
Huijuan Liu, Saibin Wu, Dewei Ran, Wei Xie
BIOCHEMICAL JOURNAL
(2020)
Article
Engineering, Environmental
Xingxing Zhang, Xin Li, Ling Tang, Yizhe Peng, Meng Qian, Yafang Guo, Haiyun Rui, Fenqin Zhang, Zhubing Hu, Yahua Chen, Yan Xia, Zhenguo Shen
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Biochemistry & Molecular Biology
Liang He, Yawen Lei, Xin Li, Qincheng Peng, Wei Liu, Keyuan Jiao, Shihao Su, Zhubing Hu, Zhenguo Shen, Da Luo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Ran Chen, Jie Zhou, Runlin Sun, Chaochao Du, Wei Xie
ACS INFECTIOUS DISEASES
(2020)
Article
Food Science & Technology
Ran Chen, Jie Zhou, Wei Xie
Summary: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tb), which poses a major health threat globally due to high mortality and drug resistance. This study focuses on the toxin-antitoxin (TA) systems present in prokaryotic organisms, with a specific emphasis on the MazEF systems in M. tb. The research provides insights into the structural binding and inhibition mechanisms of MazE/F-mt TA pairs, potentially leading to the development of peptide-based antimicrobial agents for TB treatment and addressing drug resistance by targeting novel M. tb proteins.
Article
Entomology
Qian Jia, Hui Zeng, Jinbing Zhang, Shangfang Gao, Nan Xiao, Jing Tang, Xiaolin Dong, Wei Xie
Summary: Insects can accurately respond to environmental chemical signals through chemosensory proteins (CSPs). The crystal structure of CSP8 protein from the tobacco cutworm was studied, providing insights into the molecular recognition mechanism of SlCSP8 and the CSP protein family. The research suggests that CSP8 is crucial for insects to identify certain compounds, which may have implications for future CSP-based drug design.
Article
Chemistry, Multidisciplinary
Lin Zhang, Wei Xie, Xiaojun Teng, Kui Wang, Caiyan Wang
Summary: Active ingredient extraction from medicinal plants can be improved using XynA-assisted extraction technology, specifically the use of XynA_Delta N36 enzyme, leading to higher efficiency in extracting salvianic acid A and berberine from Salvia miltiorrhiza and Phellodendron chinense.
JOURNAL OF CHEMISTRY
(2022)
Article
Biology
Ran Chen, Jie Zhou, Ling Liu, Xue-Ling Mao, Xiaolong Zhou, Wei Xie
Summary: This study reports the crystal structure of human m3C methyltransferase METTL6, generating structure models of hMETTL6 in complex with substrates. The findings provide important insights into the molecular recognition mechanism by METTL6 and may aid in METTL-based rational drug design in the future.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qian Jia, Jinbing Zhang, Hui Zeng, Jing Tang, Nan Xiao, Shangfang Gao, Huanxi Li, Wei Xie
Summary: The inactivity of AtGSDA is attributed to its inability to seclude the active site and the lack of functional amino groups or poor interactions/geometries of the ligands at the active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xin Li, Yahui Jia, Mingzhu Sun, Zikun Ji, Hui Zhang, Dan Qiu, Qiao Cai, Yan Xia, Xingxing Yuan, Xin Chen, Zhenguo Shen
Summary: The MIB1 gene in mungbean, which encodes a MATE/DTX family protein, was found to be involved in the control of plant architecture establishment. Overexpression of MIB1 partially rescued the shortened pod phenotype in Arabidopsis, and transcriptomic analysis revealed altered expression levels of genes related to phytohormone pathways and developmental regulation in the mib1 mutants, indicating the crucial role of MIB1 in mungbean.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Lin Huang, King Sing Tam, Wei Xie
Summary: Research found that the newly identified E. coli protein YicC is a founding member of the UPF0701 family and is involved in mRNA decay. The crystal structure of YicC was determined, showing an extended shape with modular domains. The enzyme mainly recognizes the consensus GUG motif in RNA cleavage, and it exists as a hexamer with a funnel shape. The catalytic domain of YicC has a novel fold and plays critical functional roles in catalysis and in vivo functions.
ACS CHEMICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiwen Liu, Jie Zhou, Ruiguang Ge, Wei Xie
Summary: Editing is a post-transcriptional process that modifies the content of nucleic acids at DNA and RNA levels, such as inosine in tRNA. Eukaryotic deaminases Tad2 and Tad3 are crucial for cell viability. The N-SpTad2 domain plays a key role in mediating protein-protein contacts, stability, and solubility of the enzyme.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)