Article
Nutrition & Dietetics
Claire Ferrua, Anais Lemoine, Alexis Mosca, Anne-Aurelie Lopes
Summary: CMV-associated protein-losing enteropathy (PLE) in children has a benign course but can lead to generalized edema. This study retrospectively describes CMV-associated PLE in children between 2009 and 2019 in two French hospitals. The study found that immunocompetent children had digestive symptoms, while immunosuppressed children had more severe symptoms. Non-invasive tests confirmed CMV infection in the majority of patients. CMV-associated PLE should be suspected in children with generalized edema and can be confirmed using non-invasive tests.
Article
Cardiac & Cardiovascular Systems
Varun J. Sharma, Ajay J. Iyengar, Diana Zannino, Thomas Gentles, Robert Justo, David S. Celermajer, Andrew Bullock, David Winlaw, Gavin Wheaton, Luke Burchill, Rachael Cordina, Yves D'Udekem
Summary: Protein losing enteropathy and plastic bronchitis are severe complications in Fontan circulation, mainly affecting patients with dominant right single ventricle, with older age being a predictor of developing these diseases and having a poorer prognosis. Heart transplantation remains the ultimate treatment option, with 30% of patients either dying or requiring transplantation within 5 years.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Genetics & Heredity
Yang Ou, Jun-Chao Yuan, Yao Zheng, Jin-Man Zhang, Tian He, Zhi Liang, Yi-Kun Zhou
Summary: This article reports a rare case of Noonan syndrome with protein-losing enteropathy. The gene mutation results of the patient indicate that the mutation in the PTPN11 gene may be related to protein-losing enteropathy.
FRONTIERS IN GENETICS
(2023)
Article
Nutrition & Dietetics
Gavriela Feketea, Alina Popp, Daniela Marcela Ionescu, Elena Camelia Berghea
Summary: Food-protein induced protein-losing enteropathy (FPIPLE) is a type of food allergy in infants characterized by low levels of protein in the blood, edema, anemia, eosinophilia, and high levels of alpha 1-antitrypsin in the stool. This study proposes a definition, diagnostic criteria, and treatment approach for FPIPLE, suggesting that dietary modification can effectively manage this condition.
FRONTIERS IN NUTRITION
(2022)
Article
Pediatrics
Yue Xi, Zhi Chen, Kun Hao, Xiaorong Liu
Summary: Protein-losing enteropathy (PLE) is a serious clinical disorder that can result in hypoproteinemia and malnutrition. PLE is often associated with gastrointestinal disorders and constrictive pericarditis. This case report highlights the marked improvement of severe hypoalbuminemia caused by PLE associated with tuberculosis-related constrictive pericarditis achieved through pericardiectomy.
FRONTIERS IN PEDIATRICS
(2022)
Article
Veterinary Sciences
Sara A. Jablonski, Allison S. W. Mazepa, M. Katherine Tolbert
Summary: This study describes the use of octreotide in dogs with protein-losing enteropathy (PLE). The results showed that octreotide was well tolerated by most dogs and had some improvement in treatment.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Charles Jones, Sara A. Jablonski, Brian K. Petroff, Daniel K. Langlois
Summary: This study investigated the relationship between ionized magnesium levels and the development of secondary hyperparathyroidism (SHPT) in dogs with chronic gastrointestinal disease and abnormally low 25(OH)D. The results suggest that hypomagnesemia may contribute to alterations in ionized calcium and parathyroid hormone in dogs with chronic enteropathy and abnormally low 25(OH)D.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Yating Wang, Xuequn Zhang
Summary: This case report describes a patient with immunocompromise who presented with weight loss, vomiting, and diarrhea. Through a series of tests and histopathology, the cause was determined to be protein-losing enteropathy caused by Strongyloides stercoralis infection. This highlights the importance of considering Strongyloides stercoralis infection in immunocompromised patients with vague gastrointestinal symptoms, and the need for more sensitive diagnostic methods.
Article
Immunology
Sebastien Sanges, Nicolas Germain, Stephane Vignes, David Seguy, Sarah Stabler, Nicolas Etienne, Louis Terriou, David Launay, Eric Hachulla, Damien Huglo, Sylvain Dubucquoi, Myriam Labalette, Guillaume Lefevre
Summary: Protein-losing enteropathy (PLE) can occur during common variable immunodeficiency (CVID) and requires higher IgG replacement therapy dosage. PLE can also mimic CVID and is associated with milder immunological abnormalities, notably mildly decreased to normal serum IgA and switched memory B cell levels.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Jefferson N. Brownell, David M. Biko, Petar Mamula, Ganesh Krishnamurthy, Fernando Escobar, Abhay Srinivasan, Pablo Laje, David A. Piccoli, Erin Pinto, Christopher L. Smith, Yoav Dori
Summary: This study reports the imaging findings of dynamic contrast magnetic resonance lymphangiography (DCMRL) in patients with protein-losing enteropathy (PLE) and characterizes lymphatic phenotypes. The results reveal that the leak is localized to the duodenum regardless of etiology.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Medicine, General & Internal
Tomoki Minemura, Shohei Kikuchi, Hiroshi Mihara, Yusuke Kamihara, Akinori Wada, Mayo Fuchino, Sohachi Nanjo, Akira Noguchi, Takashi Minamisaka, Jun Murakami, Ichiro Yasuda, Tsutomu Sato
Summary: Protein-losing enteropathy (PLE) is a rare syndrome characterized by hypoproteinemia due to gastrointestinal protein loss. Primary intestinal follicular lymphoma (PIFL), a specific variant of follicular lymphoma with only GI involvement, has not been reported as a cause of PLE. In this report, we present a case of PLE complicated with PIFL that was successfully treated with rituximab, resulting in rapid improvement of PLE and complete response of PIFL. The macroscopic findings of ulcerative lesions also improved following the treatment.
Review
Rheumatology
Manaka Goto, Yumi Tsuchida, Keigo Terada, Hideyuki Takahashi, Yusuke Sugimori, Toshihiko Komai, Yukiko Iwasaki, Hirofumi Shoda, Keishi Fujio
Summary: Protein-losing enteropathy (PLE) is a rare complication of ANCA-associated vasculitis (AAV), with only limited reports on the clinical characteristics. Patients with PLE in AAV tend to have more frequent hypocomplementemia. Although hypoalbuminemia may improve with treatment, the improvement is slow in most cases.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Song Xia, Zhong Liu, Huifang Yan, Kun Chang, Yuguang Sun, Jingmin Wang, Wenbin Shen
Summary: 22q13.3 deletion syndrome is a rare genetic disorder that can be associated with both protein-losing enteropathy and lymphedema. Research suggests that these two phenotypes may share a common genetic etiology.
Article
Cardiac & Cardiovascular Systems
Bethan A. Lemley, Dave M. Biko, Aaron G. Dewitt, Andrew C. Glatz, David J. Goldberg, Madhumitha Saravanan, Michael L. O'Byrne, Erin Pinto, Chitra Ravishankar, Jonathan J. Rome, Christopher L. Smith, Yoav Dori
Summary: IH-DCMRL is a novel diagnostic technique for identifying pathologic abdominal lymphatic flow in congenital heart disease patients, especially those with PLE. Patients with duodenal involvement on IH-DCMRL, such as enhanced duodenal wall and leakage of lymph, are more likely to have PLE. IH-DCMRL may serve as a useful risk-assessment tool for PLE in at-risk patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pediatrics
Lara Ferreira, Raquel Amaral, Fernanda Gomes, Jose Cabral
Summary: A 7-month-old boy was admitted due to acute gastro-enteritis, eventually complicated by protein-losing enteropathy and fungal sepsis. After treatment, he recovered and was discharged in good health at 19 months old.
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH
(2021)