NL-1 Promotes PINK1-Parkin-Mediated Mitophagy Through MitoNEET Inhibition in Subarachnoid Hemorrhage

Novel mitoNEET ligand NL-1 improves therapeutic outcomes in an aged rat model of cerebral ischemia/reperfusion injury

(2022) Aruvi Vijikumar et al.   EXPERIMENTAL NEUROLOGY

Investigation and modulation of interleukin-6 following subarachnoid hemorrhage: targeting inflammatory activation for cerebral vasospasm

(2022) Brandon Lucke-Wold et al.   Journal of Neuroinflammation

Effects of anticancer drugs on the cardiac mitochondrial toxicity and their underlying mechanisms for novel cardiac protective strategies

(2021) Cho-Won Kim et al.   LIFE SCIENCES

Mitophagy in Cerebral Ischemia and Ischemia/Reperfusion Injury

(2021) Luoan Shen et al.   Frontiers in Aging Neuroscience

Interleukin-6: Important Mediator of Vasospasm Following Subarachnoid Hemorrhage

(2021) Brandon Lucke-Wold et al.   CURRENT NEUROVASCULAR RESEARCH

Nanoparticle formulation and in vitro efficacy testing of the mitoNEET ligand NL-1 for drug delivery in a brain endothelial model of ischemic reperfusion-injury

(2020) Pushkar Saralkar et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: New mechanism of pioglitazone following traumatic brain injury

(2020) Heather M. Yonutas et al.   EXPERIMENTAL NEUROLOGY

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

(2020) Alex P. Seabright et al.   FASEB JOURNAL

Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

(2020) Reinaldo Marín et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats

(2019) Jianhua Peng et al.   Redox Biology

The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia

(2019) Werner J. Geldenhuys et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mitophagy Reduces Oxidative Stress Via Keap1 (Kelch-Like Epichlorohydrin-Associated Protein 1)/Nrf2 (Nuclear Factor-E2-Related Factor 2)/PHB2 (Prohibitin 2) Pathway After Subarachnoid Hemorrhage in Rats

(2019) Tongyu Zhang et al.   STROKE

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke

(2019) Syed Suhail Andrabi et al.   Disease Models & Mechanisms

Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats

(2019) Tongyu Zhang et al.   EXPERIMENTAL NEUROLOGY

Brain Ischemia/Reperfusion Injury and Mitochondrial Complex I Damage

(2019) A. Galkin   BIOCHEMISTRY-MOSCOW

Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis

(2019) Vadim Ten et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage

(2017) Yuwei Han et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Spontaneous subarachnoid haemorrhage

(2017) R Loch Macdonald et al.   LANCET

Targeting mitoNEET with pioglitazone for therapeutic neuroprotection after spinal cord injury

(2017) AlexanderG Rabchevsky et al.   Neural Regeneration Research

MitoNEET-dependent formation of intermitochondrial junctions

(2017) Alexandre Vernay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

(2017) Shenglong Cao et al.   Scientific Reports

The Updated Role of Oxidative Stress in Subarachnoid Hemorrhage

(2017) Yang Yang et al.   Current Drug Delivery

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

(2016) Koji Yamano et al.   EMBO REPORTS

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Structure–function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease

(2015) Sagi Tamir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

How Mitochondrial Dynamism Orchestrates Mitophagy

(2015) O. S. Shirihai et al.   CIRCULATION RESEARCH

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

(2013) Yang-Sung Sohn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

(2012) Ahmed F. Salem et al.   CELL CYCLE

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity

(2012) Christine M Kusminski et al.   NATURE MEDICINE

A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET

(2011) Werner J. Geldenhuys et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

(2011) Kelley Bromley-Brits et al.   Jove-Journal of Visualized Experiments

Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET

(2010) Werner J. Geldenhuys et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model

(2007) Takashi Sugawara et al.   JOURNAL OF NEUROSCIENCE METHODS