The Good and the Bad of Glutamate Receptor RNA Editing

Adenosine to Inosine editing frequency controlled by splicing efficiency

(2016) Konstantin Licht et al.   NUCLEIC ACIDS RESEARCH

RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian Brain

(2016) Mikaela Behm et al.   TRENDS IN GENETICS

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice

(2016) Megumi Akamatsu et al.   Scientific Reports

Acute Footshock Stress Induces Time-Dependent Modifications of AMPA/NMDA Protein Expression and AMPA Phosphorylation

(2016) Daniela Bonini et al.   NEURAL PLASTICITY

Chronic glutamate treatment selectively modulates AMPA RNA editing and ADAR expression and activity in primary cortical neurons

(2015) Daniela Bonini et al.   RNA Biology

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease

(2015) Khen Khermesh et al.   RNA

Acquisition of conditioned fear is followed by region-specific changes in RNA editing of glutamate receptors

(2015) Noa Brande-Eilat et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

GluA2 is rapidly edited at the Q/R site during neural differentiation in vitro

(2015) Svenja Pachernegg et al.   Frontiers in Cellular Neuroscience

Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease

(2014) Inna Gaisler-Salomon et al.   NEUROBIOLOGY OF AGING

Zebrafish Adar2 Edits the Q/R Site of AMPA Receptor Subunit gria2α Transcript to Ensure Normal Development of Nervous System and Cranial Neural Crest Cells

(2014) I-Chen Li et al.   PLoS One

A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia

(2014) Mie Kubota-Sakashita et al.   Molecular Brain

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2delivery to motor neurons

(2013) Takenari Yamashita et al.   EMBO Molecular Medicine

Kainate Receptor RNA Editing is Markedly Altered by Acute Spinal Cord Injury

(2013) Luca Caracciolo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

AMPA Receptor Properties are Modulated in the Early Stages Following Pilocarpine-induced Status Epilepticus

(2013) Isabella Russo et al.   NEUROMOLECULAR MEDICINE

Kainate Receptors in Health and Disease

(2013) Juan Lerma et al.   NEURON

Activity-Dependent A-to-I RNA Editing in Rat Cortical Neurons

(2012) N. E. Sanjana et al.   GENETICS

Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder

(2012) Rebecca Lyddon et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Cell Type-Specific Gene Expression and Editing Responses to Chronic Fluoxetine Treatment in the In Vivo Mouse Brain and Their Relevance for Stress-Induced Anhedonia

(2012) Baoman Li et al.   NEUROCHEMICAL RESEARCH

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing

(2012) Luca La Via et al.   NUCLEIC ACIDS RESEARCH

Activity-regulated RNA editing in select neuronal subfields in hippocampus

(2012) Ales Balik et al.   NUCLEIC ACIDS RESEARCH

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing

(2012) Andrew C. Penn et al.   NUCLEIC ACIDS RESEARCH

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology

(2012) Takenari Yamashita et al.   Nature Communications

Glutamate receptor RNA editing in health and disease

(2011) A. Barbon et al.   BIOCHEMISTRY-MOSCOW

Mechanisms of dendritic mRNA transport and its role in synaptic tagging

(2011) Michael Doyle et al.   EMBO JOURNAL

Deregulation of the A-to-I RNA editing mechanism in psychiatric disorders

(2011) Gilad Silberberg et al.   HUMAN MOLECULAR GENETICS

Fluoxetine affects GluK2 editing, glutamate-evoked Ca2+ influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes

(2011) Baoman Li   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Activity Regulation of Adenosine Deaminases Acting on RNA (ADARs)

(2011) Cesare Orlandi et al.   MOLECULAR NEUROBIOLOGY

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

(2011) Takuto Hideyama et al.   NEUROBIOLOGY OF DISEASE

Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels

(2011) Alessandro Barbon et al.   NEUROCHEMISTRY INTERNATIONAL

AMPA Receptor Regulation at the mRNA and Protein Level in Rat Primary Cortical Cultures

(2011) Cesare Orlandi et al.   PLoS One

Kainate receptors coming of age: milestones of two decades of research

(2011) Anis Contractor et al.   TRENDS IN NEUROSCIENCES

Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors

(2010) Alessandro Barbon et al.   JOURNAL OF NEUROCHEMISTRY

Assembly and intracellular distribution of kainate receptors is determined by RNA editing and subunit composition

(2010) Simon M. Ball et al.   JOURNAL OF NEUROCHEMISTRY

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2

(2010) T. Hideyama et al.   JOURNAL OF NEUROSCIENCE

Sculpting AMPA receptor formation and function by alternative RNA processing

(2010) Andrew C. Penn et al.   RNA Biology

Large-scale mRNA sequencing determines global regulation of RNA editing during brain development

(2009) H. Wahlstedt et al.   GENOME RESEARCH

Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line

(2009) Jun Sawada et al.   NEUROSCIENCE RESEARCH

Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons

(2008) Nicholas P. Whitney et al.   FASEB JOURNAL

Down-regulation of RNA Editing in Pediatric Astrocytomas

(2008) Caterina Cenci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presynaptic glutamate receptors: physiological functions and mechanisms of action

(2008) Paulo S. Pinheiro et al.   NATURE REVIEWS NEUROSCIENCE