The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System

Amyloid-β Induces Caspase-Dependent Loss of PSD-95 and Synaptophysin Through NMDA Receptors

(2017) Jinping Liu et al.   JOURNAL OF ALZHEIMERS DISEASE

Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression

(2015) Oliver Kaut et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

iTRAQ-based quantitative analysis of hippocampal postsynaptic density-associated proteins in a rat chronic mild stress model of depression

(2015) X. Han et al.   NEUROSCIENCE

NMDA receptor activity determines neuronal fate: location or number?

(2015) Xianju Zhou et al.   REVIEWS IN THE NEUROSCIENCES

GluN2A−/−Mice Lack Bidirectional Synaptic Plasticity in the Dentate Gyrus and Perform Poorly on Spatial Pattern Separation Tasks

(2014) Timal S. Kannangara et al.   CEREBRAL CORTEX

Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion

(2014) Qian Xu et al.   PSYCHOPHARMACOLOGY

Involvement of NR1, NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring

(2013) Hongli Sun et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N -methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

(2013) Xianju Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Sp transcription factors in the postmortem brain of chronic schizophrenia: A pilot study of relationship to negative symptoms

(2013) Raquel Pinacho et al.   JOURNAL OF PSYCHIATRIC RESEARCH

NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning

(2013) M. R. Gilmartin et al.   LEARNING & MEMORY

Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes

(2013) Johannes R Lemke et al.   NATURE GENETICS

Co-activation of NR2A and NR2B subunits induces resistance to fear extinction

(2013) Katherine Leaderbrand et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Melatonin attenuates dexamethasone-induced spatial memory impairment and dexamethasone-induced reduction of synaptic protein expressions in the mouse brain

(2013) Walaiporn Tongjaroenbuangam et al.   NEUROCHEMISTRY INTERNATIONAL

Effect of minocycline on pentylenetetrazol-induced chemical kindled seizures in mice

(2013) Nooshin Ahmadirad et al.   NEUROLOGICAL SCIENCES

Reduced Levels of NR1 and NR2A with Depression-Like Behavior in Different Brain Regions in Prenatally Stressed Juvenile Offspring

(2013) Hongli Sun et al.   PLoS One

NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

(2013) C Tackenberg et al.   Cell Death & Disease

Regulation of Cyclic AMP Response Element Binding and Hippocampal Plasticity-Related Genes by Peroxisome Proliferator-Activated Receptor α

(2013) Avik Roy et al.   Cell Reports

NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities

(2013) Audrée De Montigny et al.   NEURAL PLASTICITY

Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease

(2012) Cinzia Costa et al.   BRAIN

Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy

(2012) Nicola Berretta et al.   EPILEPSIA

Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN

(2012) M. Zheng et al.   JOURNAL OF CELL SCIENCE

Female mouse fetal loss mediated by maternal autoantibody

(2012) Li Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NR2A and NR2B subunits differentially mediate MAP kinase signaling and mitochondrial morphology following excitotoxic insult

(2012) Anthony M. Choo et al.   NEUROCHEMISTRY INTERNATIONAL

NMDA receptor/amyloid precursor protein interactions: A comparison between wild-type and amyloid precursor protein mutations associated with familial Alzheimer's disease

(2012) Neal Innocent et al.   NEUROSCIENCE LETTERS

Phosphorylation and Assembly of Glutamate Receptors After Brain Ischemia

(2012) Fan Zhang et al.   STROKE

NR2-reactive antibody decreases cell viability through augmentation of Ca2+ influx in systemic lupus erythematosus

(2011) Takahisa Gono et al.   ARTHRITIS AND RHEUMATISM

Blockade of NMDA receptors 2A subunit in the dorsal striatum impairs the learning of a complex motor skill.

(2011) Julie Lemay-Clermont et al.   BEHAVIORAL NEUROSCIENCE

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Protein Kinase Cα Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 (DLG1)

(2011) Audrey K. O'Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NMDA Receptors in Retrosplenial Cortex Are Necessary for Retrieval of Recent and Remote Context Fear Memory

(2011) K. A. Corcoran et al.   JOURNAL OF NEUROSCIENCE

Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias

(2011) Fabrizio Gardoni et al.   NEUROBIOLOGY OF AGING

Long-term consequences of a prolonged febrile seizure in a dual pathology model

(2011) Steve Gibbs et al.   NEUROBIOLOGY OF DISEASE

mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch

(2011) Jose A. Matta et al.   NEURON

Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens

(2011) Karima Chergui   NEUROPHARMACOLOGY

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

(2011) A. Ventruti et al.   NEUROSCIENCE

CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors

(2011) Anitha B. Alex et al.   NEUROTOXICOLOGY

Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity

(2011) O. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus

(2011) T. Gono et al.   RHEUMATOLOGY

Alterations of NMDA receptor subunits NR1, NR2A and NR2B mRNA expression and their relationship to apoptosis following transient forebrain ischemia

(2010) Zhian Liu et al.   BRAIN RESEARCH

Oligomerized Aβ25–35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield

(2010) Gui-Mei Wu et al.   BRAIN RESEARCH

PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

(2010) Sandra Jurado et al.   EMBO JOURNAL

Amygdala gene expression of NMDA and GABAA receptors in patients with mesial temporal lobe epilepsy

(2010) José Carlos de Moura et al.   HIPPOCAMPUS

Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation

(2010) K. A. Foster et al.   JOURNAL OF NEUROSCIENCE

Identification and Characterization of Novel NMDA Receptor Antagonists Selective for NR2A- over NR2B-Containing Receptors

(2010) E. Bettini et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

SAP97-mediated local trafficking is altered in Alzheimer disease patients' hippocampus

(2010) Elena Marcello et al.   NEUROBIOLOGY OF AGING

NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning

(2010) C.E. Andreescu et al.   NEUROSCIENCE

Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms

(2010) T. W. Faust et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of NR2A-Containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices

(2010) Julie Allyson et al.   NEURAL PLASTICITY

Glutamatergic deficits and parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia

(2009) BKY Bitanihirwe et al.   BMC Psychiatry

Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour

(2009) Sachiko Taniguchi et al.   EMBO JOURNAL

Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia

(2009) Andrea Schmitt et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion

(2009) Christopher Barkus et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hippocampal NMDA receptor subunits differentially regulate fear memory formation and neuronal signal propagation

(2009) Can Gao et al.   HIPPOCAMPUS

An Endoplasmic Reticulum Retention Signal Located in the Extracellular Amino-terminal Domain of the NR2A Subunit ofN-Methyl-d-aspartate Receptors

(2009) Shuang Qiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Aβ, and neurodegeneration in a prodromal stage of Alzheimer's disease

(2009) Rukhsana Sultana et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Both NR2A and NR2B subunits of the NMDA receptor are critical for long-term potentiation and long-term depression in the lateral amygdala of horizontal slices of adult mice

(2009) T. Muller et al.   LEARNING & MEMORY

Mechanism of differential control of NMDA receptor activity by NR2 subunits

(2009) Marc Gielen et al.   NATURE

The interaction between acute oligomer Aβ1–40 and stress severely impaired spatial learning and memory

(2009) Hei-Jen Huang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression

(2009) Tina Tze-Tsang Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

(2009) R. I. Stanika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus

(2008) Yoshiyuki Arinuma et al.   ARTHRITIS AND RHEUMATISM

Ionotropic glutamate receptor mRNA expression in the human thalamus: Absence of change in schizophrenia

(2008) Stella Dracheva et al.   BRAIN RESEARCH

Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis

(2008) Mia Levite et al.   Expert Review of Neurotherapeutics

Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression

(2008) Beata Karolewicz et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NMDA Receptor Antagonists Reveal Age-Dependent Differences in the Properties of Visual Cortical Plasticity

(2008) Jacqueline de Marchena et al.   JOURNAL OF NEUROPHYSIOLOGY

NMDA Receptor Subunit NR2A Is Required for Rapidly Acquired Spatial Working Memory But Not Incremental Spatial Reference Memory

(2008) D. M. Bannerman et al.   JOURNAL OF NEUROSCIENCE

Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test

(2008) D. L. Walker et al.   LEARNING & MEMORY

Impaired discrimination learning in mice lacking the NMDA receptor NR2A subunit

(2008) J. L. Brigman et al.   LEARNING & MEMORY

Transient global ischemia in rat brain promotes different NMDA receptor regulation depending on the brain structure studied

(2008) Severiano Dos-Anjos et al.   NEUROCHEMISTRY INTERNATIONAL

Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition

(2008) Marc Gielen et al.   NEURON

Post-synaptic density-93 mediates tyrosine-phosphorylation of the N-methyl-d-aspartate receptors

(2008) Y. Sato et al.   NEUROSCIENCE

The magnitude of hippocampal long term depression depends on the synaptic location of activated NR2-containing N-methyl-d-aspartate receptors

(2008) M. Kollen et al.   NEUROSCIENCE

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

(2008) Min Chen et al.   STROKE