Article
Chemistry, Multidisciplinary
Xiaodi Rong, Yiyuan Peng, Caiyun Liu, Mingzhu Li, Jiafan Shi, Miaohui Yu, Shuaikang Ba, Wenlong Sheng, Baocun Zhu
Summary: In this study, the issues of sensitivity, selectivity, and water solubility of CO fluorescent probes were investigated. A probe named HS-CO was designed to greatly increase the rigid plane of the probe through intramolecular cyclization, resulting in high sensitivity for CO detection. The probe was successfully used to detect CO in HeLa cells and zebrafish, demonstrating its great potential as a tool for functional analysis of CO in organisms.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Ana C. Pena, Ana Pamplona
Summary: Transition metals, especially iron, play important roles in the chemistry of life. Hemoproteins, including hemoglobin, are common targets for binding with biologically active gases such as NO and CO. Heme oxygenases, particularly HO-1, are crucial enzymes involved in heme metabolism and have documented antioxidant and anti-inflammatory properties. However, their role in infection, such as malaria, can be dual, either limiting pathogen burden or promoting pathogen growth. CO-releasing molecules have been considered as a potential alternative to CO gas inhalation for therapeutic purposes.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Slawomir Nowak, Przemyslaw Gilun, Katarzyna Koziol, Maria Romerowicz-Misielak, Magdalena Koziorowska-Gilun, Barbara Wasowska
Summary: Exogenous CO regulates mRNA transcription and protein expression of HO-1, HO-2, and PCNA, similar to a light cue.
Article
Neurosciences
Rafael A. Cazuza, Ana Luisa F. Arantes, Olga Pol, Christie R. A. Leite-Panissi
Summary: The study shows that activation of the HO-CO pathway promotes anti-allodynic effects and reduces pain aversiveness caused by peripheral inflammation by increasing the expression of MOR and DOR activated by HO-1 in the dorsal hippocampus.
BRAIN RESEARCH BULLETIN
(2021)
Review
Pharmacology & Pharmacy
Khosrow Kashfi, Kush K. Patel
Summary: This article reviews the history of carbon monoxide, highlighting its toxic effects as well as its roles as an endogenously produced molecule and therapeutic agent. The research into its physiological functions and therapeutic applications are often overshadowed by its reputation as a lethal substance.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Chemistry, Inorganic & Nuclear
Luiz Gonzaga de Franca Lopes, Florencio S. Gouveia Junior, Alda Karine Medeiros Holanda, Idalina Maria Moreira de Carvalho, Elisane Longhinotti, Tercio F. Paulo, Dieric S. Abreu, Paul Bernhardt, Marie-Alda Gilles-Gonzalez, Izaura Cirino Nogueira Diogenes, Eduardo Henrique Silva Sousa
Summary: This article discusses the roles of diatomic molecules O-2, NO, and CO in biology, as well as the sensing proteins developed by nature to perceive and respond to changes in their levels. It focuses on heme-based proteins and their advanced structural and electronic adjustments for sensing, along with their possible role in redox sensing. Finally, the potential therapeutic interventions on these gas sensors and the design of small diatomic molecules for medical treatments are highlighted.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Yixiao Luo, Rafi Ullah, Jinfeng Wang, Yuru Du, Shihao Huang, Li Meng, Yuan Gao, Miao Gong, Ewa Galaj, Xi Yin, Haishui Shi
Summary: The study demonstrated that carbon monoxide (CO) has significant antidepressant and anxiolytic effects, providing protection through activation of HO-1 and exogenous CO administration. This research revealed a novel function of the HO-1/CO system, offering a promising therapeutic target for the treatment of depression and anxiety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Giuseppe Broggi, Sebastiano Giallongo, Maria Failla, Lidia Puzzo, Teresio Avitabile, Daniele Tibullo, Alfio Distefano, Valeria Pittala, Michele Reibaldi, Guido Nicola Zanghi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Giovanni Li Volti, Nicolo Musso
Summary: The study revealed the important role of HO-1 in regulating uveal melanoma progression, with an increase of HO-1 promoting cellular proliferation and wound healing ability of tumor cells, suggesting HO-1 protein expression may serve as a potential prognostic and therapeutic factor in UM patients.
Article
Biochemistry & Molecular Biology
Tao Wu, Xiaotian Liu, Ting Wang, Li Tian, Hao Qiu, Feng Ge, Jing Zhu, Liang Shi, Ailiang Jiang, Hanshou Yu, Ang Ren
Summary: This study found that the HO/CO system can respond to heat stress and regulate Ganoderma lucidum's ganoderic acid biosynthesis and cell wall integrity by regulating the Slt-MAPK phosphorylation level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yoon Kyung Choi, Young-Myeong Kim
Summary: Heme oxygenase and its metabolites have dual roles in neurovascular diseases, potentially causing cytotoxic ferroptosis via iron accumulation, but also exhibiting regenerative potential and neurovascular protective effects through CO-mediated signaling pathway, antioxidant properties of bilirubin, and iron-mediated ferritin synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Kinga Krukowska, Marcin Magierowski
Summary: Gastrointestinal tract cancers present a challenge for researchers in terms of finding effective molecular agents for targeted therapies. Ongoing clinical trials offer new perspectives, but long-term treatments remain unsuccessful. Novel pharmacological and molecular approaches are being studied for the prevention and treatment of GI cancers. Additionally, pharmacological tools that release carbon monoxide have shown therapeutic properties in treating GI pathologies.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Jun Fang, Rayhanul Islam, Shanghui Gao, Cheng Zhang, Ryotaro Kunisaki, Shogo Sakaguchi, Naoya Honda, Jian-Rong Zhou, Kazumi Yokomizo
Summary: Heme oxygenase (HO-1) is crucial for cellular protection against stresses and diseases, but its overexpression in tumors is also commonly observed. Maintaining a balance of HO-1 levels in both host and tumor cells is essential for cancer occurrence, progression, and prognosis, with high HO-1 levels in the host being beneficial for cancer prevention and suppressing HO-1 in tumor cells possibly becoming a therapeutic strategy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Tamas Gall, David Petho, Annamaria Nagy, Gyorgy Balla, Jozsef Balla
Summary: The study shows that oxidized hemoglobins, globin-derived peptides, and heme trigger diverse biological responses, including toll-like receptor 4 activation with inflammatory response, reprogramming of cellular metabolism, differentiation, stress, and even death. The damage caused by oxidized hemoglobin and heme to cells and tissues is related to the pathological consequences of hemorrhage and hemolysis in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)