Conditional gene deletion with DiCre demonstrates an essential role for CRK3 inLeishmania mexicanacell cycle regulation

Evaluation of α,β-Unsaturated Ketones as Antileishmanial Agents

(2015) Miguel A. Vasquez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro

(2015) Eva Řezníčková et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Fragment-Based QSAR Modeling and Combinatorial Design of Pyrazole-Derived CRK3 Inhibitors as Potent Antileishmanials

(2014) Sukriti Goyal et al.   Chemical Biology & Drug Design

Recently targeted kinases and their inhibitors—the path to clinical trials

(2014) Stefan Knapp et al.   CURRENT OPINION IN PHARMACOLOGY

Probing druggability and biological function of essential proteins inLeishmaniacombining facilitated null mutant and plasmid shuffle analyses

(2014) Mariko Dacher et al.   MOLECULAR MICROBIOLOGY

An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

(2014) Antonia Efstathiou et al.   Parasites & Vectors

Robust inducible Cre recombinase activity in the human malaria parasitePlasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle

(2013) Christine R. Collins et al.   MOLECULAR MICROBIOLOGY

Highly Sensitive In Vivo Imaging of Trypanosoma brucei Expressing “Red-Shifted” Luciferase

(2013) Alex P. McLatchie et al.   PLoS Neglected Tropical Diseases

Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms

(2012) Nicole Andenmatten et al.   NATURE METHODS

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Leishmania tropica experimental infection in the rat using luciferase-transfected parasites

(2012) Dalit Talmi-Frank et al.   VETERINARY PARASITOLOGY

Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells

(2012) E Castanys-Muñoz et al.   Cell Death & Disease

ATG5 Is Essential for ATG8-Dependent Autophagy and Mitochondrial Homeostasis in Leishmania major

(2012) Roderick A. M. Williams et al.   PLoS Pathogens

Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines

(2011) Radek Jorda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3

(2011) Laura A. T. Cleghorn et al.   ChemMedChem

Identification of substrates of an S-phase cell cycle kinase fromLeishmania donovani

(2011) Anup Kumar Maity et al.   FEBS LETTERS

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

(2011) M. B. Rogers et al.   GENOME RESEARCH

The CDK inhibitors in cancer research and therapy

(2011) Jonas Cicenas et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

(2011) Roderick G. Walker et al.   PLoS Neglected Tropical Diseases

Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178

(2010) Felipe C. Gomes et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage

(2010) M. A. Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity

(2010) L. Madeira da Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red-emitting luciferases for bioluminescence reporter and imaging applications

(2009) Bruce R. Branchini et al.   ANALYTICAL BIOCHEMISTRY

2-(3-Aryl-3-oxopropen-1-yl)-9-tert-butyl-paullones: A New Antileishmanial Chemotype

(2008) Christina Reichwald et al.   JOURNAL OF MEDICINAL CHEMISTRY