Article
Materials Science, Multidisciplinary
Ying Mao, Robert Guidoin, Yan Li, Gaetan Brochu, Ze Zhang, Lu Wang
Summary: Blending L-alpha-phosphatidylcholine (PC) with PLGA to yield hybrid scaffolds alters the physical properties and wettability, affecting biodegradability and biocompatibility. The addition of PC decreases fiber diameter and increases porosity and hydrophilicity, although it also reduces mechanical strength of the scaffolds.
MATERIALS & DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Jeong Eun Song, Dae Hoon Lee, Gilson Khang, Sun-Jung Yoon
Summary: Collagen, with its low antigenicity and excellent cell adhesion properties, is widely used as a biomaterial for bone, cartilage, and skin regeneration. A study showed that a scaffold mixed with duck feet-derived collagen and Poly(lactic-co-glycolic acid) reduced inflammation and improved bone regeneration. By including hydroxyapatite, a key osteoconductive material, in the scaffold, we found that increasing the concentration of duck feet-derived collagen not only improved its strength, but also enhanced cell proliferation and osteogenic differentiation. Furthermore, the addition of hydroxyapatite promoted osteogenic differentiation. The study demonstrated that the 80 wt% duck feet-derived collagen/Poly(lactic-co-glycolic acid)/hydroxyapatite scaffold promotes bone mineralization and collagen deposition while reducing inflammation, making it an excellent biomaterial for bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, General & Internal
Peifang Xu, Pengjie Chen, Qi Gao, Yiming Sun, Jing Cao, Han Wu, Juan Ye
Summary: This study successfully fabricated three types of PLGA scaffolds with varying pore architectures. In vitro and in vivo experiments showed that fibroblast and rMGCs could adhere well onto the pore walls, with fibroblast elongating along the axially aligned porous structure. The axially aligned scaffold group exhibited faster degradation rate with a matched integration rate compared to the random scaffold group, suggesting its potential as an alternative for eyelid tarsal plate substitutes.
FRONTIERS IN MEDICINE
(2023)
Article
Polymer Science
Yi-Hsun Yu, Shih-Jyun Shen, Yung-Heng Hsu, Ying-Chao Chou, Ping-Chun Yu, Shih-Jung Liu
Summary: In this study, a novel nanofibrous scaffold was developed for repairing ruptured Achilles tendons. It integrated multiple biomolecules layer by layer and achieved sustained release to enhance tendon healing. The experimental results demonstrated that the scaffold significantly improved the load-to-failure of the repaired tendons.
Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Chemistry, Multidisciplinary
Honglei Kang, Xudong Jiang, Zhiwei Liu, Fan Liu, Guoping Yan, Feng Li
Summary: Biodegradable scaffolds based on biomedical polymeric materials were prepared using composite materials of PTMC/PLA/HA and PTMC/HA, showing low toxicity, good biodegradability, and biocompatibility while enhancing the cell multiplication ability of osteoblast cells.
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Article
Chemistry, Physical
Morteza Bazgir, Wei Zhang, Ximu Zhang, Jacobo Elies, Morvarid Saeinasab, Phil Coates, Mansour Youseffi, Farshid Sefat
Summary: The study evaluated the characteristics and degradation effects of PLGA- and PCL-based nanofibrous scaffolds, finding that longer electrospinning times resulted in stronger mechanical properties and maintained fiber structure. Both PCL and PLGA scaffolds demonstrated adequate degradation over time, with slight increase in fiber diameter and substantial decrease in pore size and porosity percentage. This experiment suggests promise for PCL and PLGA in tissue engineering and regenerative medicine applications.
Article
Chemistry, Multidisciplinary
Taegyun Yeo, Young-Gwang Ko, Eun Jin Kim, Oh Kyoung Kwon, Ho Yun Chung, Oh Hyeong Kwon
Summary: 3D-printed PGA/HAp scaffolds demonstrate significant potential for promoting bone tissue regeneration with higher compressive strength and biodegradability. Clinical experiments show a higher rate of bone regeneration and bone density.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Basma Ahmed, Mai H. Ragab, Rania A. Galhom, Hayam Y. Hassan
Summary: This study investigated the odontogenic potential of dental pulp stem cells (DPSCs) after induction with three different bioactive materials (AB, TC, and MTA) combined with two different types of scaffolds. The results demonstrated that the PCL-NC-Mg-HA scaffold had better odontogenic differentiation effects on cultured DPSCs compared to the PCL-NC-HA scaffold. Additionally, MTA was found to be the most effective bioactive material for inducing the odontogenic differentiation of cultured DPSCs compared to AB and TC.
Review
Physiology
Xiaoyao Huang, Zihan Li, Anqi Liu, Xuemei Liu, Hao Guo, Meiling Wu, Xiaoxue Yang, Bing Han, Kun Xuan
Summary: Dental pulp regeneration is crucial for restoring damaged dental pulp and teeth, with odontogenic mesenchymal stem cells playing a key role. The regenerative abilities of these cells are easily influenced by the surrounding microenvironment.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Konstantinos Loukelis, Foteini Machla, Athina Bakopoulou, Maria Chatzinikolaidou
Summary: This study investigates the impact of kappa-carrageenan on dental pulp stem cells and reveals that its integration in scaffolds significantly enhances the odontogenic potential of DPSCs, supporting dentin-pulp regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yanan Li, Chaoran Liu, Guanghong Han
Summary: This review focuses on the therapeutic effects of extracellular vesicles (EVs) derived from dental stem cells (DSCs) in pulp healing, providing a new perspective in the field of regenerative endodontics.
Article
Dentistry, Oral Surgery & Medicine
Hongyu Li, Sibei Huo, Xinyu He, Daimo Guo, Yingling Liu, Liwei Zheng, Xin Zhou
Summary: The study aimed to investigate the role of CARMN in the odontogenic differentiation of dental pulp cells (DPCs). CARMN expression was found to be higher in odontoblasts compared to DPCs. Overexpression of CARMN enhanced odontogenic differentiation, while its inhibition impaired the process. CARMN functioned by interacting with EZH2 and impairing its activity. The findings suggest that CARMN acts as a modulator in the odontogenic differentiation of DPCs by regulating EZH2.