Distinct profiles of anhedonia and reward processing and their prospective associations with quality of life among individuals with mood disorders

Leading professional health bodies have called for the wider adoption of Patient Reported Outcome Measures, such as quality of life, in research and clinical practice as a means for understanding why the global burden of depression continues to climb despite increased rates of treatment use. Here, we examined whether anhedonia-an often recalcitrant and impairing symptom of depression-along with its neural correlates, was associated with longitudinal changes in patient-reported quality of life among individuals seeking treatment for mood disorders. We recruited 112 participants, including n = 80 individuals with mood disorders (58 unipolar, 22 bipolar) and n = 32 healthy controls (63.4% female). We assessed anhedonia severity along with two electroencephalographic markers of neural reward responsiveness (scalp-level 'Reward Positivity' amplitude and source-localized reward-related activation in the dorsal anterior cingulate cortex), and assessed quality of life at baseline, 3- and 6-month follow-up. Anhedonia emerged as a robust correlate of quality of life cross-sectionally and longitudinally among individuals with mood disorders. Furthermore, increased neural reward responsiveness at baseline was associated with greater improvements in quality of life over time, and this improvement was mediated by longitudinal improvements in anhedonia severity. Finally, differences in quality of life observed between individuals with unipolar and bipolar mood disorders were mediated by differences in anhedonia severity. Our findings indicate that anhedonia and its reward-related neural correlates are linked to variability in quality of life over time in individuals with mood disorders. Treatments capable of improving anhedonia and normalizing brain reward function may be necessary for improving broader health outcomes for individuals seeking treatment for depression.ClinicalTrials.gov identifier: NCT01976975

Automated summary

Leading professional health bodies advocate for the use of Patient Reported Outcome Measures, such as quality of life, to understand the continued rise of depression despite increased treatment rates. This study examined the relationship between anhedonia, a symptom of depression, and its neural correlates with changes in patient-reported quality of life among individuals seeking treatment for mood disorders. Findings showed that anhedonia strongly correlated with quality of life among individuals with mood disorders. Improvements in quality of life were associated with increased neural reward responsiveness and reduced anhedonia severity over time. Differences in quality of life between unipolar and bipolar mood disorders were mediated by differences in anhedonia severity. These findings highlight the importance of targeting anhedonia and normalizing brain reward function in depression treatment for improved overall health outcomes.