Review
Biochemistry & Molecular Biology
Ali Gholami, Khosro Farhadi, Fatemeh Sayyadipour, Masoud Soleimani, Fakhredin Saba
Summary: This review summarizes the role of lncRNAs in lymphomas and their potential clinical value. It has been found that lncRNAs play a critical role in lymphoma carcinogenesis by affecting apoptosis, cell proliferation, invasion, and response to chemotherapy.
Article
Agronomy
Li-Wei Meng, Guo-Rui Yuan, Meng-Ling Chen, Wei Dou, Tian-Xing Jing, Li-Sha Zheng, Meng-Lan Peng, Wen-Jie Bai, Jin-Jun Wang
Summary: This study identified lncRNAs potentially related to malathion resistance in Bactrocera dorsalis, with two lncRNAs possibly influencing resistance by modulating the structure or components of the cuticle.
PEST MANAGEMENT SCIENCE
(2021)
Review
Oncology
Sajad Najafi, Seyyed Hossein Khatami, Marjan Khorsand, Zeinab Jamali, Zahra Shabaninejad, Mostafa Moazamfard, Jamal Majidpoor, Seyed Mohsen Aghaei Zarch, Ahmad Movahedpour
Summary: New research has shown that long non-coding RNAs (lncRNAs) play crucial roles in various biological processes, including the development of complex human diseases like cancer. Although the specific regulation mechanisms of many lncRNAs in cancer are still unknown, a few have been identified. This study provides a summary of recent advances in understanding the mechanisms and functions of lncRNAs in cancer, with a focus on their roles as oncogenes and tumor suppressors, as well as their potential use as biomarkers for cancer diagnosis and prognosis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Changsheng Guo, Yuanqing Hua, Zuanhao Qian
Summary: This study identified differentially expressed lncRNAs and genes in Kawasaki disease (KD), as well as constructed ceRNA networks involving miRNAs and mRNAs. The study found specific lncRNAs (PSORS1C3, LINC00999, SNHG5) and genes (GATA3, SOD2, MAPK14, PPARG) that may play a key role in the pathogenesis and development of KD. Validation in a separate dataset showed that intravenous immunoglobulin treatment alleviated the deregulated RNA profiles in KD patients.
Review
Cell Biology
Ziyu Wang, Xiang Li, Liangliang Huang, Ge Liu, Yan Chen, Binbin Li, Xueyan Zhao, Rong Xie, Yunman Li, Weirong Fang
Summary: This article summarizes 35 lncRNAs associated with stroke and elucidates their roles and mechanisms in stroke. The study suggests that these lncRNAs regulate pathological processes in stroke and have potential value in predicting prognosis and developing treatments for stroke.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wenhui Wang, Bei Tian, Zhongping Ning, Xinming Li
Summary: Atrial fibrillation is a common arrhythmia with increased research in clinical diagnosis and treatment. Long noncoding RNAs have been shown to play a role in cardiovascular diseases and are gaining attention in the identification and function of atrial fibrillation.
MOLECULAR BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Yuanbo Zhang, Duan Wang, Na Wu, Xinghua Chen, Zhiquan Yuan, Xiaoyue Jia, Chengying Li, Qin Hu, Yanxiu Chen, Zhihui Zhang, Li Zhong, Yafei Li
Summary: This study identified five plasma lncRNAs associated with stroke and all-cause mortality in patients with atrial fibrillation (AF). Among them, H19 was found to be significantly associated with stroke risk and adding it to the CHA(2)DS(2)-VASc score improved the predictive power of the model.
CHINESE MEDICAL JOURNAL
(2022)
Article
Immunology
Hani Sabaie, Zoha Salkhordeh, Mohammad Reza Asadi, Soudeh Ghafouri-Fard, Nazanin Amirinejad, Mahla Askarinejad Behzadi, Bashdar Mahmud Hussen, Mohammad Taheri, Maryam Rezazadeh
Summary: This study aimed to clarify the molecular regulatory mechanisms involved in T-cells responses in MS by exploring the lncRNA-associated ceRNA axes. The research identified a ceRNA regulatory relationship among SNHG1, hsa-miR-197-3p, YOD1, ZNF101 and downstream connected genes, potentially playing a role in the pathogenesis of MS. Pathway enrichment analysis showed that differentially expressed mRNAs were enriched in Protein processing in endoplasmic reticulum and Herpes simplex virus 1 infection pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yangyang You, Wei Wang, Wenshu Zhu, Jian Xu
Summary: This study discusses differentially expressed lncRNAs and their potential interaction with mRNAs in AF. LncRNA AC009509.2 could be a new potential biomarker for AF prediction.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Genetics & Heredity
Yuqi Wen, Cailin He, Yang Wang, Siqin Zeng, Bo Yang, Xingui Xiong
Summary: This study identified differentially expressed lncRNAs and mRNAs in rheumatoid arthritis through microarray analysis and comprehensive analysis methods, and predicted their functions in the pathogenesis of the disease. However, the exact roles and mechanisms still need further investigation.
BMC MEDICAL GENOMICS
(2022)
Article
Genetics & Heredity
Xinmiao Wu, Yuanhua Gu, Shiqiang Li, Shiwei Guo, Jiqing Wang, Yuzhu Luo, Jiang Hu, Xiu Liu, Shaobin Li, Zhiyun Hao, Mingna Li, Bingang Shi
Summary: In this study, the expression profiles of lncRNAs in cashmere goat skin tissue were analyzed using RNA sequencing. The differentially expressed lncRNAs were found to be associated with cashmere fiber traits such as fiber follicle development, fiber diameter, and fiber color through their target genes involved in related signaling pathways.
Article
Plant Sciences
Shunkai Hu, Yimeng Hu, Huiling Mei, Jianjie Li, Wei Xuan, Anburaj Jeyaraj, Zhen Zhao, Yuxin Zhao, Rui Han, Xuan Chen, Xinghui Li
Summary: In this study, a total of 16,452 lncRNAs were identified in tea plants under nitrogen stress and control conditions, of which 9,451 were differentially expressed lncRNAs (DE-lncRNAs). Co-expression clustering analysis revealed that nitrogen-responsive lncRNAs may be involved in various biological processes, including plant hormone signal transduction, nitrogen metabolism, and protein processing in the endoplasmic reticulum. The findings of this study provide valuable insights into the potential regulation of lncRNAs on nitrogen stress and offer resources for improving the nitrogen use efficiency of tea plants.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Biochemical Research Methods
Eun-Gyeong Park, Sung-Jin Pyo, Youxi Cui, Sang-Ho Yoon, Jin-Wu Nam
Summary: This review discusses the specific expression of long non-coding ribonucleic acids (lncRNAs) in tumor and immune cells, summarizes their regulatory functions at the cell type level, and highlights the application of single-cell RNA-sequencing (scRNA-seq) in studying the cell type-specific functions of lncRNAs in the tumor immune microenvironment (TIME).
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Psychiatry
Hani Sabaie, Mahdi Gholipour, Mohammad Reza Asadi, Samin Abed, Mirmohsen Sharifi-Bonab, Mohammad Taheri, Bashdar Mahmud Hussen, Serge Brand, Seyedeh Morvarid Neishabouri, Maryam Rezazadeh
Summary: This study used bioinformatics to identify ceRNA axes associated with long non-coding RNA (lncRNA) in the BA10 region of the brain in patients with schizophrenia. The study identified DElncRNA-miRNA-DEmRNA axes and identified key genes and miRNAs related to the pathophysiology of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Nicola Mosca, Aniello Russo, Nicoletta Potenza
Summary: Transcriptome complexity is a fascinating field, especially with the discovery of numerous non-coding RNA biotypes through high-throughput sequencing. This review focuses on antisense long non-coding RNAs and their role in hepatocellular carcinoma (HCC). Dysregulation of antisense lncRNAs significantly contributes to hepatocarcinogenesis, affecting tumor onset, progression, and treatment response. Understanding the mechanisms and functions of these RNA molecules is important for potential therapeutic targets and diagnostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
