Article
Medicine, Research & Experimental
Yasemin Acar, Duygu Agagunduz, Paola De Cicco, Raffaele Capasso
Summary: This paper provides a literature review on the neurological roles of flavonoids, one of the most abundant phytochemical families, in Parkinson's disease (PD). Flavonoids have been shown to have beneficial effects on PD, such as protecting dopaminergic neurons, improving motor and cognitive abilities, regulating signaling pathways, and modulating oxidative stress and neuroinflammation. In addition, flavonoids can also promote the growth of beneficial strains and reduce pathogenic strains by changing the composition of bacteria in gut microbiota.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Jing-Qi Fan, Wei-Jing Lu, Wei-Qiang Tan, Wei-Cheng Feng, Li-Xing Zhuang
Summary: This article summarizes the similarities and differences in treatment concepts and methods between Chinese and Western medicine for Parkinson's disease, as well as the latest evidence and prospective treatment options for acupuncture in Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Vasanti Suvarna, Kajal Deshmukh, Manikanta Murahari
Summary: Alpha-synuclein plays a key role in neurodegenerative diseases, especially Parkinson's disease. Recent advances in oligonucleotide chemistry have shown potential in targeting alpha-synuclein for therapeutic intervention in neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiaoyu Song, Wanfu Wu, Margaret Warner, Jan-Ake Gustafsson
Summary: This review discusses the role of liver X receptors (LXRs) in glial cells in the central nervous system (CNS). LXRs regulate genes involved in cholesterol homeostasis, inflammatory responses, and glutamate homeostasis. Studies on LXR knockout mice have shown that LXR beta is crucial for the health of various types of neurons in both CNS and peripheral nervous system. LXRs are also important for cerebrospinal fluid homeostasis. Despite the neurological deficits observed in LXR-deficient rodents, defective LXR signaling has only been identified in multiple sclerosis among human neurodegenerative diseases. Targeting LXRs in glial cells may hold potential for treating neurodegenerative diseases and disorders caused by abnormal neuronal migration during development.
Review
Biochemistry & Molecular Biology
Dominika Natalia Wojewska, Arjan Kortholt
Summary: This review provides a comprehensive overview of the current state of the art, presenting recent developments and challenges in developing LRRK2 inhibitors, and discussing extensively the potential targeting strategies from the protein perspective. As currently there are three LRRK2-targeting agents in clinical trials, more developments are predicted in the upcoming years.
Review
Geriatrics & Gerontology
Soojung Ahn, Kristen Springer, Jessie S. Gibson
Summary: This scoping review synthesized existing evidence on social withdrawal in Parkinson's disease (PD) and found that social withdrawal is associated with negative outcomes for individuals with PD, such as decreased quality of life. However, more research is needed to understand the true scope of social withdrawal in PD and develop effective interventions.
Review
Biochemistry & Molecular Biology
Berenice A. Gutierrez, Agenor Limon
Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, result from the dysfunction and death of neurons. The presence of small soluble oligomers, such as amyloid beta and Tau oligomers in Alzheimer's, and alpha-synuclein oligomers in Parkinson's, is toxic and relevant to the development of these diseases. These oligomers increase during the early stages of pathology, leading to disruption of synaptic plasticity, synapse loss, inflammation, imbalance between excitatory and inhibitory transmission, and cognitive impairment. The absence of Tau oligomers at synapses in individuals with advanced Alzheimer's pathology but preserved cognition suggests that resilience mechanisms may depend on the interactions between soluble oligomers and their synaptic targets.
Article
Endocrinology & Metabolism
Hai Duc Nguyen, Byung Pal Yu, Ngoc Hong Minh Hoang, Won Hee Jo, Hae Young Chung, Min-Sun Kim
Summary: PRL is a promising molecule for the treatment of neurodegenerative disorders like Alzheimer's disease and Parkinson's disease, but the mechanisms responsible for its effects are still not fully understood. Modulating PRL functions and targeting immune mechanisms are key strategies for developing preventive or therapeutic approaches.
NEUROENDOCRINOLOGY
(2022)
Review
Environmental Sciences
Paola Brinez-Gallego, Dennis Guilherme da Costa Silva, Marcos Freitas Cordeiro, Ana Paula Horn, Mariana Appel Hort
Summary: This systematic review summarizes the use of neurotoxins as experimental models of Parkinson's disease in zebrafish embryos and larvae. A total of 56 articles were selected, utilizing neurotoxins such as MPTP, MPP+, 6-OHDA, paraquat/diquat, rotenone, and others to induce Parkinson's disease. The studies examined neurobehavioral function, dopaminergic neuron markers, oxidative stress biomarkers, and other relevant parameters in the zebrafish embryo-larval model. The review provides valuable information for researchers in selecting appropriate chemical models to study experimental parkinsonism.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Article
Neurosciences
Zubo Wu, Suyuan Wu, Tao Liang, Lin Wang
Summary: The study found that the level of Lp-PLA2 in PD patients is significantly higher, and positively correlated with the severity of the disease. Lp-PLA2 may be an independent risk factor for PD and can be used as a target for early detection and clinical intervention.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Junjiao Zhang, Jianing Jin, Dongning Su, Tao Feng, Huiqing Zhao
Summary: This study conducted a systematic review and meta-analysis, which revealed that the accumulation of tau protein in the brains of Parkinson's disease patients is associated with cognitive impairment. The tau PET tracer shows potential as a biomarker for the diagnosis of Parkinson's disease cognitive impairment (PDCI).
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Randrita Pal, Supriyo Choudhury, Hrishikesh Kumar, Sanjit Dey, Nilansu Das, Barnali Ray Basu
Summary: Parkinson's disease (PD) and vitamin D deficiency (VDD) are closely linked, and understanding the role of vitamin D in PD is crucial for therapeutic strategies. Genetic polymorphisms of vitamin D-related genes, such as VDR and GC, as well as vitamin D metabolising genes, such as CYP2R1 and CYP27A1, may play a role in PD. Literature review shows that certain polymorphisms are associated with PD severity, while others affect vitamin D levels without influencing disease severity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Simara Larissa Fanalli, Bruna Pereira Martins Silva, Julia Dezen Gomes, Mariah Castro Durval, Vivian Vezzoni de Almeida, Gabriel Costa Monteiro Moreira, Barbara Silva-Vignato, Juliana Afonso, Felipe Andre Oliveira Freitas, James Mark Reecy, James Eugene Koltes, Dawn Koltes, Dorian Garrick, Luciana Correia de Almeida Regitano, Julio Cesar de Carvalho Balieiro, Gerson Barreto Mourao, Luiz Lehmann Coutinho, Heidge Fukumasu, Severino Matias de Alencar, Albino Luchiari Filho, Aline Silva Mello Cesar
Summary: Pigs are used as an animal model for studying metabolic diseases in humans. This study investigated the effects of different types of oils (canola, fish, and soybean oils) on pig gene expression and identified the impacted metabolic pathways. The results provide insights into the biological mechanisms underlying the effects of dietary oils on gene expression in pigs.
FRONTIERS IN GENETICS
(2023)
Review
Genetics & Heredity
Egle Jakubauskiene, Arvydas Kanopka
Summary: Alternative pre-mRNA splicing is essential for generating protein diversity and is implicated in the pathogenesis of neurological disorders. The splicing machinery also plays a role in cellular adaptation to different microenvironments, such as hypoxia. Understanding the alternative splicing of genes associated with Alzheimer's and Parkinson's diseases can provide insights into the development of these neurodegenerative conditions, including the influence of cellular hypoxic microenvironments.
Review
Cell Biology
Heechang Moon, Bokwang Kim, Inbeom Kwon, Yohan Oh
Summary: Neurons derived from human pluripotent stem cells (hPSCs) are valuable for studying neural development and neurodegenerative diseases. Research on hPSC-based cell therapy for Parkinson's disease (PD) has shown promising results, but the lack of reliable lineage identification methods is a significant obstacle.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Surgery
Christos Tsagkaris, Marios Papadakis, Lolita Matiashova
AMERICAN JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Gaber El-Saber Batiha, Stephano Tambo Tene, John Oluwafemi Teibo, Hazem M. Shaheen, Oyerinde Samson Oluwatoba, Titilade Kehinde Ayandeyi Teibo, Hayder M. Al-kuraishy, Ali Al-Garbee, Athanasios Alexiou, Marios Papadakis
Summary: This review provides an overview of the traditional uses, phytochemistry, pharmacological activities, and safety of Malva sylvestris. The study found that the leaves and flowers of Malva sylvestris contain various bioactive compounds, which contribute to its anti-inflammatory, antimicrobial, hepatoprotective, laxative, antiproliferative, and antioxidant properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gaber El-Saber Batiha, John Oluwafemi Teibo, Hazem M. Shaheen, Opeyemi Abigail Akinfe, Aya Ahmed Awad, Titilade Kehinde Ayandeyi Teibo, Athanasios Alexiou, Marios Papadakis
Summary: The roles of plants and their products in medicine cannot be underestimated. Cupressus sempervirens, a plant found in different regions, has been investigated for its biological properties and phytochemical composition. This review focuses on the interactions, traditional uses, and biological actions of Cupressus sempervirens and its products.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hayder M. Al-Kuraishy, Ali Al-Gareeb, Abdulrahman A. Alsayegh, Zaki H. Hakami, Nizar A. Khamjan, Hebatallah M. Saad, Gaber El-Saber Batiha, Michel De Waard
Summary: In this review, the potential link between visceral obesity (VO) and Alzheimer's disease (AD) is evaluated. Tissue hypoxia and inflammatory changes induced by VO may increase the risk of AD, and the abnormal insulin signaling pathway is also related to the pathogenesis of AD. Additionally, the enlargement of visceral adipose tissue is associated with the deposition of A beta, and the activation of various inflammatory signaling pathways has a negative impact on cognitive function and the progression of AD.
NEUROCHEMICAL RESEARCH
(2023)
Article
Cell Biology
Dalia Mohamed Ali, Mohamed H. Mahmoud, Rehab Ahmed Rifaai, Michael Atef Fawzy, Medhat Atta, Nermeen N. Welson, Gaber El-Saber Batiha, Athanasios Alexiou, Marios Papadakis, Walaa Yehia Abdelzaher
Summary: The aim of this study was to investigate the potential protective effect of diacerein (DIA) on gentamicin (GNT)-induced parotid toxicity in rats. The results showed that GNT caused oxidative stress, inflammation, apoptosis, and damage to the parotid gland, while DIA significantly alleviated these effects and improved the histopathological picture. It was also found that DIA modulated the TLR4/NF-kappa B/IL-1 beta and TRPC1/CHOP signaling pathways in the protection against GNT-induced parotid toxicity.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Gaber El-Saber Batiha, Ali Esmail Al-Snafi, Mahdi M. M. Thuwaini, John Oluwafemi Teibo, Hazem M. M. Shaheen, Ayomide Peter Akomolafe, Titilade Kehinde Ayandeyi Teibo, Hayder M. M. Al-kuraishy, Ali I. I. Al-Garbeeb, Athanasios Alexiou, Marios Papadakis
Summary: Morus alba, a fast-growing shrub or tree, has various medicinal uses. The plant parts have been used to treat nerve disorders, as analgesics, antibacterials, and many more. The plant contains a wide range of chemical components and has shown various pharmacological effects, including antimicrobial, anti-inflammatory, and antioxidant properties.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Immunology
Mohammed Alrouji, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) is a degenerative disorder caused by the damage to certain neurons in the brain. The use of non-steroidal anti-inflammatory drugs (NSAIDs) to treat musculoskeletal problems in PD patients can have both beneficial and harmful effects on the progression of the disease. NSAIDs can potentially prevent the development of PD by reducing neuroinflammation, but they may also inhibit neuroprotective mechanisms and worsen neuroinflammation. In conclusion, the effect of NSAIDs on PD neuropathology is still uncertain and further research is needed.
INFLAMMOPHARMACOLOGY
(2023)
Review
Clinical Neurology
Naif H. Ali, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This review explores the potential role of tPA and neuroserpin in the pathogenesis of AD. Increased PAI-1 activity in AD contributes to the accumulation of Aβ. Neuroserpin plays a critical role in AD development by inhibiting the neuroprotective effects of tPA and reducing Aβ clearance.
ACTA NEUROLOGICA BELGICA
(2023)
Review
Clinical Neurology
Saud A. Alnaaim, Hayder M. Al-kuraishy, Mohammad Mitran Zailaie, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Acromegaly, caused by benign GH-secreting pituitary adenoma, is associated with the development of acute ischemic stroke (AIS) through the formation of cerebral vessel aneurysm, thrombosis, alteration of cerebral microcirculation, and acromegaly-induced cardio-metabolic disorders.
ACTA NEUROLOGICA BELGICA
(2023)
Review
Cell Biology
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Hebatallah M. Saad, Gaber El-Saber Batiha, Daniel J. Klionsky
Summary: This study explores the protective and harmful effects of autophagy in the pathogenesis of multiple sclerosis (MS). Autophagy can prevent the progression of MS by reducing oxidative stress and inflammatory disorders, but over-activated autophagy can worsen the neuropathology of MS. Additionally, autophagy can modulate cell proliferation and affect demyelination and remyelination. Overall, autophagy plays a significant role in the pathogenesis of MS.
Article
Medicine, Research & Experimental
Moneerah J. Alqahtani, Walaa A. Negm, Hebatallah M. Saad, Esraa A. Salem, Ismail A. Hussein, Hanaa A. Ibrahim
Summary: The present study investigated the potential protective effect of Fenofibrate (Fen), Diosmetin (D), and their combination against testicular damage caused by cisplatin (Cis). The results showed that Fen and D could alleviate the harmful effects of Cis on the testes through upregulation of antioxidant activities and downregulation of lipid peroxidation, apoptosis, and inflammation. Additionally, the combination therapy Fen/D40 exhibited a more pronounced enhancement of these effects than either treatment alone.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Saud A. Alnaaim, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Naif H. Ali, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Epilepsy is a chronic neurological disease characterized by recurrent seizures. Despite the effectiveness of anti-epileptic agents (AEAs) in controlling epilepsy, a significant proportion of patients do not respond to conventional treatment. Therefore, adding FDA-approved drugs with anti-seizure activity, such as metformin, to the treatment regimen is a logical approach. This review aims to explore the mechanism of action of metformin in epilepsy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Cell Biology
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Asmaa A. Khalifa, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: Alzheimer's disease (AD) is a neurodegenerative disease characterized by the accumulation of phosphorylated tau proteins and amyloid beta (A beta) deposition. NEP inhibitors might have both beneficial and deleterious effects on AD neuropathology. Clinical studies have shown promising safety findings regarding the use of ARNI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Hend Mostafa Selim, Athanasios Alexiou, Marios Papadakis, Walaa A. Negm, Gaber El-Saber Batiha
Summary: Parkinson's disease (PD) is a neurodegenerative brain disease caused by the loss of dopaminergic neurons in the substantia nigra. Vitamin D (VD) plays a critical role in maintaining brain functions and can protect against PD by modulating dopaminergic neurons and reducing oxidative stress and neuroinflammation. However, the therapeutic effect of VD in well-established PD remains controversial.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mubarak Alruwaili, Hayder M. M. Al-kuraishy, Athanasios Alexiou, Marios Papadakis, Barakat M. M. ALRashdi, Omnya Elhussieny, Hebatallah M. M. Saad, Gaber El-Saber Batiha
Summary: Multiple sclerosis is an autoimmune neurodegenerative disease caused by immune cells damaging the myelin sheath. Fibrinogen plays a crucial role in the pathogenesis of MS by triggering neuroinflammation. Inhibition of the fibrinogen cascade may reduce MS severity.
NEUROCHEMICAL RESEARCH
(2023)
