Article
Physiology
Longyuan Jia, Yuchen Jing, Ding Wang, Shuai Cheng, Chen Fu, Xiangyu Chu, Chenye Yang, Bo Jiang, Shijie Xin
Summary: Based on network pharmacology and molecular docking technology, this study explored the potential of Artemisia annua L. (A. annua) in treating abdominal aortic aneurysm (AAA). The main active components of A. annua were identified, along with their targets. Enrichment analysis revealed potential mechanisms related to signaling pathways such as PI3K-Akt and fluid shear stress. Molecular docking results supported the potential therapeutic efficacy of A. annua in treating AAA.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xueqing Fu, Fangyuan Zhang, Yanan Ma, Danial Hassani, Bowen Peng, Qifang Pan, Yuhua Zhang, Zhongxiang Deng, Wenbo Liu, Jixiu Zhang, Lei Han, Dongfang Chen, Jingya Zhao, Ling Li, Xiaofen Sun, Kexuan Tang
Summary: Terpenes are the largest class of secondary metabolites in plants, playing essential roles in plant growth and development as well as having economic value. Through engineering experiments, it has been found that plants can efficiently produce high-value terpenes through photosynthesis at a low cost.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siyu Guo, Yingying Tan, Zhihong Huang, Yikui Li, Weiyu Liu, Xiaotian Fan, Jingyuan Zhang, Antony Stalin, Changgeng Fu, Zhishan Wu, Penglong Wang, Wei Zhou, Xinkui Liu, Chao Wu, Shanshan Jia, Jinyan Zhang, Xiaoxia Duan, Jiarui Wu
Summary: This study revealed that ferulic acid, caffeic acid, and rosmarinic acid in Danhong injection (DHI) can inhibit acute myocardial infarction (AMI) by regulating PLB, CaMK II, SERCA, etc. The calcium signaling pathway plays a critical role in this process.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Hend Dawood, Ismail Celik, Reham S. Ibrahim
Summary: This study provides deeper insights into the molecular mechanisms of A. annua in cancer treatment using an integrated approach. It demonstrates that A. annua has inhibitory effects on cancer cell proliferation and identifies the cancer-associated targets and signaling pathways.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Agricultural Engineering
Jose Abramo Marchese, Jorge F. S. Ferreira, Rita Maria Moraes, Franck E. Dayan, Michelle F. F. Rodrigues, Jorge Jamhour, Lucas Vinicius Dallacorte
Summary: In this study, a phenological scale was established for Artemisia annua L. to facilitate successful cross-pollination and breeding. The scale divided the plant's growth cycle into the vegetative phase and reproductive phase, with distinct stages identified through daily observations and photographs. The experiments showed that genotypes from different geographic origins demonstrate better synchronization under both short days and low temperatures, and the concentration and yield of artemisinin vary depending on the photoperiod and growth phase.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Plant Sciences
Do Yeon Kim, So-Ri Son, Jae Youn Kim, Ji Won Min, Chang Hyeon Kong, Keontae Park, Mijin Jeon, Woo Chang Kang, Seo Yun Jung, Jung-Hye Choi, Dae Sik Jang, Jong Hoon Ryu
Summary: This study aimed to investigate the effects of Artemisia annua extract on postmenopausal symptoms in ovariectomized mice. The results showed that the extract improved cognitive dysfunction, anxiety, anhedonia, and depression, and activated the ERK, Akt, and GSK-30/β-catenin signaling pathway and hippocampal synaptic plasticity. These findings suggest that A. annua could be a novel treatment for postmenopausal symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yexiao Tang, Xiaobo Li, Yueming Yuan, Hongying Zhang, Yuanyuan Zou, Zhiyong Xu, Qin Xu, Jianping Song, Changsheng Deng, Qi Wang
Summary: Through network analysis and molecular docking, we have found that Artemisia annua has the potential to treat COVID-19. Artemisia annua can prevent and inhibit the inflammatory processes related to COVID-19 by regulating inflammatory response, proliferation, differentiation, and apoptosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Plant Sciences
Tingyu Ma, Han Gao, Dong Zhang, Wei Sun, Qinggang Yin, Lan Wu, Tianyuan Zhang, Zhichao Xu, Jianhe Wei, Yanyan Su, Yuhua Shi, Dandan Ding, Ling Yuan, Gangqiang Dong, Liang Leng, Li Xiang, Shilin Chen
Summary: Artemisinin is the most effective ingredient in treating malaria, making it important to study the genetic regulation of Artemisia annua. This study found that alternative splicing in the artemisinin biosynthetic pathway is influenced by light, potentially regulating sesquiterpenoid biosynthesis. The analysis provided valuable insights into the complexity of transcriptome and proteome in plant alternative splicing.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Horticulture
Federica Blando, Francesca Rizzello, Miriana Durante, Angelo De Paolis, Sofia Caretto, Giovanni Mita
Summary: This study established an in vitro regeneration process of Artemisia annua L. and investigated the potential of tissue culture to induce new variability in artemisinin metabolism. The results showed that adventitious shoot induction could provide a useful strategy to impact artemisinin metabolism through in vitro manipulation.
Article
Plant Sciences
Boran Dong, Xingxing Wang, Rui Jiang, Shiyuan Fang, Jinxing Li, Qing Li, Zong You Lv, Wan Sheng Chen
Summary: In this study, AaCycTL was found to regulate trichome development and affect the content of artemisinin in Artemisia annua. Overexpression of AaCycTL in Arabidopsis and A. annua resulted in changes in wax coverage on the plant surface and decreased trichome density. The interaction between AaCycTL and AaTAR1 was identified, indicating a potential role of AaCycTL in regulating trichome density and artemisinin biosynthesis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Chunqing Fu, Keyu Zhang, Manyuan Wang, Feng Qiu
Summary: This study developed a method for analyzing the active components of Artemisia annua extract in rat plasma. The absorption, metabolism, and impact on drug metabolism of different components were investigated. The results provide a foundation for understanding the mechanism of action of Artemisia annua in the body.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Praveen Kumar Pasala, Madhuri Donakonda, Prasanth S. N. B. K. Dintakurthi, Mithun Rudrapal, Sampath A. Gouru, Kolla Ruksana
Summary: This study used network pharmacology to investigate the mechanisms of silybin in the treatment of myocardial infarction (MI), and an in vivo experiment was conducted to evaluate its cardioprotective effect in MI rats. The results showed that silybin shares overlapping genes with MI and alleviates the symptoms of MI by improving antioxidant levels through the PI3K-Akt/HIF-1 pathway.
Article
Biochemistry & Molecular Biology
Martin Kondza, Marta Mandic, Ivona Ivancic, Sanda Vladimir-Knezevic, Ivica Brizic
Summary: The study aimed to investigate the inhibitory effect of Artemisia annua extract on CYP2B6 and CYP3A4 enzymes, as well as the type of inhibition, the presence of reversible or pseudo-irreversible inhibition, and the possible heme destruction. The methanolic extract of Artemisia annua showed significant inhibition on CYP2B6 (by almost 90%) and CYP3A4 enzymes (by almost 70%). It also exhibited irreversible inhibition, suggesting potential interactions with drugs and dietary supplements.
Article
Integrative & Complementary Medicine
Wen-Shu Zhou, Marta Silva, Chao Yang, Shuai Li, Yi-Tian Chen, Wen-Hua Zheng
Summary: Oxidative stress is a significant factor in the development of Alzheimer's disease (AD). A Chinese herbal medicine called Artemisia annua extract has been found to have strong antioxidant properties and can improve cognitive function in AD mice. Through network pharmacology and various experimental approaches, key genes and signaling pathways related to oxidative stress have been identified. Further studies have shown that the extract can protect against H2O2-induced damage and prevent cognitive decline and pathological changes in AD mice. These findings suggest the potential of Artemisia annua extract for the prevention and treatment of AD.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Veterinary Sciences
Shiwei Guo, Jiaxin Ma, Yuanyuan Xing, Lulu Shi, Linghui Zhang, Yuanqing Xu, Xiao Jin, Sumei Yan, Binlin Shi
Summary: This study investigated the effects of Artemisia annua L. aqueous extract (AAE) on intestinal immune and antioxidative function in broilers. The results showed that AAE had a positive impact on small intestinal immune function by regulating signal pathways and gene expression. Additionally, AAE improved antioxidative function in the small intestinal mucosa through the Nrf2 signal pathway. Regression analysis identified the optimal dosage range of AAE in the broiler diet as 1.12-1.38 g/kg.
FRONTIERS IN VETERINARY SCIENCE
(2022)