Review
Biochemistry & Molecular Biology
Tasuku Matsuoka, Masakazu Yashiro
Summary: TGF-beta plays a crucial role in the development, invasion, and metastasis of gastrointestinal cancers. Understanding the mechanisms and functions of TGF-beta signaling is important for diagnosis, prognosis, and the development of targeted therapies.
Article
Oncology
Dariusz Kajdaniuk, Dorota Hudy, Joanna Katarzyna Strzelczyk, Krystyna Mlynarek, Szymon Slomian, Andrzej Potyka, Ewa Szymonik, Janusz Strzelczyk, Wanda Foltyn, Beata Kos-Kudla, Bogdan Marek
Summary: This study found that the dysregulation of TGF beta/Smads pathway genes may play a role in the pathogenesis of kidney cancer. The expression of these genes was found to be altered in both the tumor tissues and the tumor microenvironment, which may impact the aggressiveness and spread of the tumor.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tsugumasa Toma, Hiroshi Tateishi, Kensaku Kawakami, Taha F. S. Ali, Masahiro Kamo, Kazuaki Monde, Yuta Nakashima, Mikako Fujita, Masami Otsuka
Summary: Metastasis is the main cause of mortality in solid tumors, but there are no available antimetastatic drugs on the market. This study focused on a synthetic compound called HPH-15, which showed anti-EMT and anti-cell migration activities in non-small-cell lung cancer cells. HPH-15 was found to inhibit downstream TGF-beta signaling and could potentially lead to the development of new antimetastatic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Takashi Yamaguchi, Katsunori Yoshida, Miki Murata, Kanehiko Suwa, Koichi Tsuneyama, Koichi Matsuzaki, Makoto Naganuma
Summary: Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by fatty degeneration of the liver, insulin resistance, oxidative stress, lipotoxicity, adipokine secretion, endotoxins released by gut microbiota, and endoplasmic reticulum stress. NAFLD can progress to nonalcoholic steatohepatitis (NASH), fibrosis, and advanced liver diseases. Phosphorylated Smad isoforms play a crucial role in the early diagnosis of hepatocellular carcinoma (HCC) in NASH patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Urology & Nephrology
Aglaia Chalkia, Harikleia Gakiopoulou, Irini Theohari, Periklis G. Foukas, Dimitrios Vassilopoulos, Dimitrios Petras
Summary: This study investigated the expression of TGF-β1/Smad signaling in different types of glomerulonephritis and found that TGF-β1 expression is an independent risk factor for progression to chronic kidney disease. The co-expression pattern of pSmad3 and Smad7 in glomerulus is correlated with renal inflammation.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wenwen Ding, Danhua Zhou, Shimeng Zhang, Jiaping Qian, Lingxia Yang, Lei Tang
Summary: This study demonstrates that Trimetazidine (TMZ) can inhibit liver fibrosis and hepatic stellate cell proliferation induced by CCl4 and TGF-beta. TMZ exerts its effects by blocking the activation of TGF beta/Smad signaling pathway. These findings provide new insights into the potential application of TMZ in the treatment of liver fibrosis.
Review
Immunology
Karthik Chandiran, Linda S. Cauley
Summary: Cytotoxic T lymphocytes (CTLs) are crucial for defense against intracellular pathogens and tumors, requiring efficient migration to locate and destroy infected cells in different regions of the body. The transforming growth factor-beta (TGF-beta) and canonical SMAD-dependent signaling pathways are essential for coordinating changes in homing receptor expression and ensuring successful migration of CTLs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li
Summary: This article discusses the diverse role of transforming growth factor-beta (TGF-beta) in tendon injuries and its regulation of tendon repair through both the Smad and non-Smad signaling pathways.
Article
Biochemistry & Molecular Biology
Lauren K. K. Wareham, Amy E. E. Whitener, Hang-Jing Wu, Shu-Yu Wu, Hassane S. S. Mchaourab, Douglas P. P. Mortlock, Rachel W. W. Kuchtey, John Kuchtey
Summary: Mutations in ADAMTS10 can cause different ocular diseases, glaucoma in dogs and Weill-Marchesani Syndrome in humans. This study shows that ADAMTS10 plays a crucial role in retinal ganglion cell development through regulation of TGF beta signaling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Cell Biology
Aftab Taiyab, Judith West-Mays
Summary: Injury to the ocular lens disrupts cell-cell and cell-capsule/basement membrane interactions, leading to a series of interconnected signaling events. These events include cell-adhesion and growth factor-mediated signaling pathways that play a crucial role in the induction and progression of epithelial-mesenchymal transition (EMT) and fibrosis of lens epithelial cells. The lens provides a simple and ideal system to study injury-induced signaling pathways associated with EMT and fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Saurav Bhowmick, Saleena Alikunju, P. M. Abdul-Muneer
Summary: This study aims to investigate the activation of TGF-beta 1 induced by ethanol and its associated mechanisms of neuroinflammation and apoptosis. The findings suggest that ethanol-induced activation of TGF-beta 1 impairs antioxidant signaling pathways and leads to neuroinflammation and apoptosis.
Article
Hematology
Ryosuke Taniguchi, Yuichi Ohashi, Jung Seok Lee, Haidi Hu, Luis Gonzalez, Weichang Zhang, John Langford, Yutaka Matsubara, Bogdan Yatsula, George Tellides, Tarek M. Fahmy, Katsuyuki Hoshina, Alan Dardik
Summary: Endothelial cell-targeted TGF-beta inhibition may be a translational strategy to improve AVF patency.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rizwana Afroz, Hirushi Kumarapperuma, Quang V. N. Nguyen, Raafat Mohamed, Peter J. Little, Danielle Kamato
Summary: This study investigates the dependency of TGFBR1-mediated Smad2 carboxy terminal phosphorylation on the activation of TGFBR1 via TLR4. The results show that LPS-mediated Smad2 phosphorylation is inhibited by the presence of GM6001 inhibitor, but not affected by Y27632 and DPI inhibitors. Additionally, LPS stimulates the expression of PAI-1 mRNA through the activation of TGFBR1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Medicine, Research & Experimental
Jitang Chen, Ze-yang Ding, Si Li, Sha Liu, Chen Xiao, Zifu Li, Bi-xiang Zhang, Xiao-ping Chen, Xiangliang Yang
Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.
