Insight into the dynamics of the Ixodes ricinus nymphal midgut proteome

A high-quality Ixodes scapularis genome advances tick science

(2023) Sandip De et al.   NATURE GENETICS

Serine pseudoproteases in physiology and disease

(2022) Nina Zupanič et al.   FEBS Journal

Serpins in Tick Physiology and Tick-Host Interaction

(2022) Muhammad Nadeem Abbas et al.   Frontiers in Cellular and Infection Microbiology

Quantitative proteomics analysis reveals core and variable tick salivary proteins at the tick‐vertebrate host interface

(2022) Chaima Bensaoud et al.   MOLECULAR ECOLOGY

Characterization and manipulation of the bacterial community in the midgut of Ixodes ricinus

(2022) Melina Garcia Guizzo et al.   Parasites & Vectors

Transcriptomic analysis of the tick midgut and salivary gland responses upon repeated blood-feeding on a vertebrate host

(2022) José María Medina et al.   Frontiers in Cellular and Infection Microbiology

Defensins as a promising class of tick antimicrobial peptides: a scoping review

(2022) Jiahui Wu et al.   Infectious Diseases of Poverty

Novel tick glutathione transferase inhibitors as promising acaricidal compounds

(2022) Katiussa Paula Cover Ozelame et al.   Ticks and Tick-Borne Diseases

Comparison of the hemolysis machinery in two evolutionarily distant blood-feeding arthropod vectors of human diseases

(2021) Moataza Dorrah et al.   PLoS Neglected Tropical Diseases

Tick Immune System: What Is Known, the Interconnections, the Gaps, and the Challenges

(2021) Andréa C. Fogaça et al.   Frontiers in Immunology

Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion

(2021) Jan Kotál et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus

(2021) Barbora Kascakova et al.   Acta Crystallographica Section D-Structural Biology

Functionalized Terpolymer-Brush-Based Biointerface with Improved Antifouling Properties for Ultra-Sensitive Direct Detection of Virus in Crude Clinical Samples

(2021) Michala Forinová et al.   ACS Applied Materials & Interfaces

The unusual cell wall of the Lyme disease spirochaete Borrelia burgdorferi is shaped by a tick sugar

(2021) Tanner G. DeHart et al.   Nature Microbiology

A journey into the world of insect lipid metabolism

(2020) Umut Toprak et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Poor Unstable Midgut Microbiome of Hard Ticks Contrasts With Abundant and Stable Monospecific Microbiome in Ovaries

(2020) Melina Garcia Guizzo et al.   Frontiers in Cellular and Infection Microbiology

Potent Inhibitors of Thioredoxin Glutathione Reductase: Grail of Anti-Schistosome Drug within Reach?

(2020) Timir Tripathi et al.   ACS Infectious Diseases

Interactions between Borrelia burgdorferi and ticks

(2020) Cheyne Kurokawa et al.   NATURE REVIEWS MICROBIOLOGY

Catalogue of stage-specific transcripts in Ixodes ricinus and their potential functions during the tick life-cycle

(2020) Pavlina Vechtova et al.   Parasites & Vectors

Prediction, mapping and validation of tick glutathione S-transferase B-cell epitopes

(2020) Charles Ndawula et al.   Ticks and Tick-Borne Diseases

Ticks Resist Skin Commensals with Immune Factor of Bacterial Origin

(2020) Beth M. Hayes et al.   CELL

Interactions between Borrelia burgdorferi and its hosts across the enzootic cycle

(2020) Jennifer D. Helble et al.   PARASITE IMMUNOLOGY

The major allergen Der p 2 is a cholesterol binding protein

(2019) Kavita Reginald et al.   Scientific Reports

Haem Biology in Metazoan Parasites – ‘The Bright Side of Haem’

(2019) Jan Perner et al.   TRENDS IN PARASITOLOGY

Tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs to mice

(2019) Tereza Pospisilova et al.   INFECTION AND IMMUNITY

Biosynthesis, modifications and degradation of chitin in the formation and turnover of peritrophic matrix in insects

(2019) Xiaojian Liu et al.   JOURNAL OF INSECT PHYSIOLOGY

Insect Sterol Nutrition: Physiological Mechanisms, Ecology, and Applications

(2019) Xiangfeng Jing et al.   Annual Review of Entomology

Inducible glutathione S-transferase ( Ir GST1) from the tick Ixodes ricinus is a haem-binding protein

(2018) Jan Perner et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Multiple legumain isoenzymes in ticks

(2018) David Hartmann et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Whole body transcriptomes and new insights into the biology of the tick Ixodes ricinus

(2018) N. Pierre Charrier et al.   Parasites & Vectors

GOATOOLS: A Python library for Gene Ontology analyses

(2018) D. V. Klopfenstein et al.   Scientific Reports

Sialome diversity of ticks revealed by RNAseq of single tick salivary glands

(2018) Jan Perner et al.   PLoS Neglected Tropical Diseases

Lipid metabolism in insect disease vectors

(2018) Katia C. Gondim et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Spectrophotometric analysis of lipid used to examine the phenology of the tick Ixodes ricinus

(2018) Swaid Abdullah et al.   Parasites & Vectors

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

(2018) Michael Nguyen Trinh et al.   eLife

Progressive behavioral, physiological, and transcriptomic shifts over the course of prolonged starvation in ticks

(2018) Andrew J. Rosendale et al.   MOLECULAR ECOLOGY

A saposin deficiency model in Drosophila : Lysosomal storage, progressive neurodegeneration and sensory physiological decline

(2017) Samantha J. Hindle et al.   NEUROBIOLOGY OF DISEASE

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

(2017) Neil D Rawlings et al.   NUCLEIC ACIDS RESEARCH

A repertoire of protease inhibitor families in Amblyomma americanum and other tick species: inter-species comparative analyses

(2017) Lindsay M. Porter et al.   Parasites & Vectors

Pathogen-mediated manipulation of arthropod microbiota to promote infection

(2017) Nabil M. Abraham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization

(2017) Sukanya Narasimhan et al.   Nature Communications

Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences

(2016) Claudia Manzoni et al.   BRIEFINGS IN BIOINFORMATICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick–Host Interactions

(2016) Jindřich Chmelař et al.   TRENDS IN PARASITOLOGY

Multienzyme degradation of host serum albumin in ticks

(2016) Daniel Sojka et al.   Ticks and Tick-Borne Diseases

Ancestral reconstruction of tick lineages

(2016) Ben J. Mans et al.   Ticks and Tick-Borne Diseases

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

(2016) Monika Gulia-Nuss et al.   Nature Communications

Acquisition of exogenous haem is essential for tick reproduction

(2016) Jan Perner et al.   eLife

RNA-seq analyses of the midgut from blood- and serum-fed Ixodes ricinus ticks

(2016) Jan Perner et al.   Scientific Reports

Ovarian Ecdysteroidogenesis in Both Immature and Mature Stages of an Acari, Ornithodoros moubata

(2015) Mari Horigane Ogihara et al.   PLoS One

Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host

(2015) Michalis Kotsyfakis et al.   Scientific Reports

Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete

(2014) Sukanya Narasimhan et al.   Cell Host & Microbe

Identification and partial characterisation of new members of the Ixodes ricinus defensin family

(2014) Miray Tonk et al.   GENE

A Systems Level Analysis Reveals Transcriptomic and Proteomic Complexity inIxodes RicinusMidgut and Salivary Glands During Early Attachment and Feeding

(2014) Alexandra Schwarz et al.   MOLECULAR & CELLULAR PROTEOMICS

Transferred interbacterial antagonism genes augment eukaryotic innate immune function

(2014) Seemay Chou et al.   NATURE

Oxysterol-binding proteins: Functions in cell regulation beyond lipid metabolism

(2013) Marion Weber-Boyvat et al.   BIOCHEMICAL PHARMACOLOGY

A digestive prolyl carboxypeptidase in Tenebrio molitor larvae

(2013) Irina A. Goptar et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Chitin Deacetylase-Like Protein Is a Predominant Constituent of Tick Peritrophic Membrane That Influences the Persistence of Lyme Disease Pathogens within the Vector

(2013) Toru Kariu et al.   PLoS One

New insights into the machinery of blood digestion by ticks

(2013) Daniel Sojka et al.   TRENDS IN PARASITOLOGY

Interaction of the tick immune system with transmitted pathogens

(2013) Ondřej Hajdušek et al.   Frontiers in Cellular and Infection Microbiology

Characterization of Gut-associated Cathepsin D Hemoglobinase from TickIxodes ricinus(IrCD1)

(2012) Daniel Sojka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tick salivary secretion as a source of antihemostatics

(2012) Jindrich Chmelar et al.   Journal of Proteomics

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

(2012) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases

(2012) Daniel Sojka et al.   Parasites & Vectors

Molecular characterization of novel sulfotransferases from the tick, Ixodes scapularis

(2011) Sivakamasundari Pichu et al.   BMC BIOCHEMISTRY

Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?

(2011) Terhi Vihervaara et al.   CHEMISTRY AND PHYSICS OF LIPIDS

In silico analysis of glutathione S-transferase supergene family revealed hitherto unreported insect specific δ- and ɛ-GSTs and mammalian specific μ-GSTs in Ixodes scapularis (Acari: Ixodidae)

(2011) B.P. Niranjan Reddy et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Characterization of the oxysterol-binding protein gene family in the yellow fever mosquito, Aedes aegypti

(2011) Q. Fu et al.   INSECT MOLECULAR BIOLOGY

Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus

(2011) Zdeněk Franta et al.   Parasites & Vectors

Functional characterization of two defensin isoforms of the hard tick Ixodes ricinus

(2011) Tereza Chrudimská et al.   Parasites & Vectors

Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

(2011) M. S. Deffieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoamine Neurotransmitters as Substrates for Novel Tick Sulfotransferases, Homology Modeling, Molecular Docking, and Enzyme Kinetics

(2010) Emine Bihter Yalcin et al.   ACS Chemical Biology

PERILIPIN-Dependent Control of Lipid Droplet Structure and Fat Storage in Drosophila

(2010) Mathias Beller et al.   Cell Metabolism

Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides

(2010) Carlos E Cruz et al.   Parasites & Vectors

Leucine aminopeptidase, HlLAP, from the ixodid tick Haemaphysalis longicornis, plays vital roles in the development of oocytes

(2010) Takeshi Hatta et al.   PARASITOLOGY INTERNATIONAL

Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics

(2009) Martin Horn et al.   CHEMISTRY & BIOLOGY

Structure and Mode of Action of Microplusin, a Copper II-chelating Antimicrobial Peptide from the Cattle TickRhipicephalus(Boophilus)microplus

(2009) Fernanda D. Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids

(2009) Riikka Hynynen et al.   JOURNAL OF LIPID RESEARCH

New Insights into Peritrophic Matrix Synthesis, Architecture, and Function

(2008) Dwayne Hegedus et al.   Annual Review of Entomology

Overview: Ticks as vectors of pathogens that cause disease in humans and animals

(2008) Jose de la Fuente   Frontiers in Bioscience-Landmark

Cystatins: Biochemical and structural properties, and medical relevance

(2008) ">Vito Turk   Frontiers in Bioscience-Landmark

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High-throughput functional annotation and data mining with the Blast2GO suite

(2008) S. Gotz et al.   NUCLEIC ACIDS RESEARCH

Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

(2008) Sandra Macedo-Ribeiro et al.   PLoS One

A Cysteine Protease Is Critical for Babesia spp. Transmission in Haemaphysalis Ticks

(2008) Naotoshi Tsuji et al.   PLoS Pathogens

BmSI-7, a novel subtilisin inhibitor from Boophilus microplus, with activity toward Pr1 proteases from the fungus Metarhizium anisopliae

(2007) Sergio D. Sasaki et al.   EXPERIMENTAL PARASITOLOGY